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The effect of ephedrine and phenylephrine on BIS values during propofol anaesthesia

Published online by Cambridge University Press:  01 March 2006

D. Takizawa ,
E. Takizawa ,
S. Miyoshi ,
F. Kawahara ,
N. Ito ,
J. Ishizeki ,
S. Koizuka  and
H. Hiraoka
D. Takizawa
Affiliation:
Gunma University, Graduate School of Medicine, Department of Anesthesiology, Maebashi, Japan Saitama Cardiovascular and Pulmonary Center, Department of Anesthesiology, Osato-gun, Saitama, Japan
E. Takizawa
Affiliation:
Gunma University, Graduate School of Medicine, Department of Anesthesiology, Maebashi, Japan
S. Miyoshi
Affiliation:
Saitama Cardiovascular and Pulmonary Center, Department of Anesthesiology, Osato-gun, Saitama, Japan
F. Kawahara
Affiliation:
Saitama Cardiovascular and Pulmonary Center, Department of Anesthesiology, Osato-gun, Saitama, Japan
N. Ito
Affiliation:
Gunma University, Graduate School of Medicine, Department of Anesthesiology, Maebashi, Japan
J. Ishizeki
Affiliation:
Gunma University, Graduate School of Medicine, Department of Anesthesiology, Maebashi, Japan
S. Koizuka
Affiliation:
Gunma University, Graduate School of Medicine, Department of Anesthesiology, Maebashi, Japan
H. Hiraoka
Affiliation:
Saitama Cardiovascular and Pulmonary Center, Department of Anesthesiology, Osato-gun, Saitama, Japan
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Extract

Summary

Backgrounds: The purpose of this study was to evaluate the effect of ephedrine and phenylephrine on propofol concentrations and bispectral index during propofol anesthesia. Methods: General anaesthesia was induced with propofol and was maintained with propofol (4 mg kg−1 h−1) and fentanyl. Vecuronium was used to facilitate the artificial ventilation of the lungs. Patients with systolic blood pressure > 90 mmHg were defined as the control group (n = 16). Patients who had to be treated for larger decreases in arterial blood pressure (systolic blood pressure <90 mmHg) were randomly assigned to receive ephedrine 0.1 mg kg−1 (n = 20) or phenylephrine 2 μg kg−1 (n = 20). Propofol concentrations were determined before (baseline) and at 3 and 10 min after the administration of ephedrine or phenylephrine. Bispectral index was monitored continuously. Cardiac output was determined using a pulmonary arterial catheter. Results: Ten minutes after drug injection, bispectral index in the ephedrine group increased significantly compared with the baseline and was significantly larger than that in the control or phenylephrine group. Eight patients in the ephedrine group had bispectral index >60, whereas no patient in the control or phenylephrine groups had bispectral index >60. There were no significant differences in propofol concentrations or cardiac output relative to baseline at 3 or 10 min after the administration of ephedrine or phenylephrine. Conclusions: Ephedrine increases bispectral index values without decreasing propofol concentrations during general anesthesia.

Keywords

ANAESTHETICS INTRAVENOUS, propofolSYMPATHOMIMETICS, ephedrine, phenylephrineELECTROENCEPHALOGRAPHY, bispectral indexPHARMACOKINETICS, drug interactionsANAESTHESIA, INTRAVENOUS, depth of anaesthesia
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 23 , Issue 8 , August 2006 , pp. 654 - 657
Copyright
© 2006 European Society of Anaesthesiology

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