Hostname: page-component-78c5997874-lj6df Total loading time: 0 Render date: 2024-11-02T22:23:52.315Z Has data issue: false hasContentIssue false
  • English
  • Français

Effect of different doses of cisatracurium on intraocular pressure in sedated patients

Published online by Cambridge University Press:  16 August 2006

S. M. Sator-Katzenschlager ,
M. J. Oehmke ,
M. Kontaratos ,
A. Wedrich ,
G. Heinze  and
C. Weinstabl
S. M. Sator-Katzenschlager
Affiliation:
University of Vienna, Department of Anaesthesiology and General Intensive Care (B), Vienna, Austria University of Vienna, Department of Anaesthesiology and General Intensive Care (A), Vienna, Austria
M. J. Oehmke
Affiliation:
University of Vienna, Department of Anaesthesiology and General Intensive Care (B), Vienna, Austria
M. Kontaratos
Affiliation:
University of Vienna, Department of Anaesthesiology and General Intensive Care (A), Vienna, Austria
A. Wedrich
Affiliation:
University of Vienna, Department of Ophthalmology and Optometrics, Vienna, Austria
G. Heinze
Affiliation:
University of Vienna, Departments of Medical Computer Sciences, Vienna, Austria
C. Weinstabl
Affiliation:
University of Vienna, Department of Anaesthesiology and General Intensive Care (A), Vienna, Austria
Get access

Abstract

Background and objective: The aim was to examine the course of intraocular pressure after relaxation with different doses of cisatracurium.

Methods: The investigation was carried out as a prospective, randomized double-blind study in a crossover design in 30 postoperative patients with stable haemodynamic and respiratory function (ASA I and II). To exclude any disrupting factors, patients remained intubated and continuously sedated. Twenty patients received an intubation dose (2 × ED95) of cisatracurium (0.1 mg kg−1) compared with atracurium (0.5 mg kg−1). In a second series, 10 patients were given an effective dose, ED95 (0.05 mg kg−1), and a repeat dose (0.02 mg kg−1) of cisatracurium. The intraocular pressure was determined before (T0) as well as 1 (T1), 5 (T5), 10 (T10), 15 (T15), 20 (T20) and 45 (T45) min after bolus administration.

Results: Intraocular pressure decreased after an intubation dose of either cisatracurium or atracurium, and reached a minimum after 10 min (6.7 ± 2.2 and 7.9 ± 2.1 mmHg, respectively). There was no significant difference between either muscle relaxant (P = 0.27). When lower doses of cisatracurium (0.05 and 0.02 mg kg−1) were applied, the intraocular pressure also decreased, albeit to a lesser extent and with a delayed onset (8.4 ± 1.9 mmHg after 10 min, 9.9 ± 3.4 mmHg after 15 min). There was no significant difference between dosages (P = 0.44).

Conclusions: Cisatracurium is a useful drug in patients when a decrease of intraocular pressure is wanted and where muscle relaxation is necessary and acceptable.

Keywords

neuromuscular non-depolarizing agentsatracuriumcisatracuriumocularphysiologyintraocular pressure
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 19 , Issue 11 , November 2002 , pp. 823 - 828
Copyright
2002 European Society of Anaesthesiology

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)