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General versus regional anaesthesia for cataract surgery: effects on neutrophil apoptosis and the postoperative pro-inflammatory state

Published online by Cambridge University Press:  16 August 2006

Y. Goto ,
S. L. Ho ,
J. McAdoo ,
N. F. Fanning ,
J. Wang ,
H. P. Redmond  and
G. D. Shorten
Y. Goto
Affiliation:
Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital, University College Cork, Ireland
S. L. Ho
Affiliation:
Department of Ophthalmology, Cork University Hospital, University College Cork, Ireland
J. McAdoo
Affiliation:
Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital, University College Cork, Ireland
N. F. Fanning
Affiliation:
Department of Surgery, Cork University Hospital, University College Cork, Ireland
J. Wang
Affiliation:
Department of Surgery, Cork University Hospital, University College Cork, Ireland
H. P. Redmond
Affiliation:
Department of Surgery, Cork University Hospital, University College Cork, Ireland
G. D. Shorten
Affiliation:
Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital, University College Cork, Ireland
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Abstract

At clinically relevant concentrations, volatile anaesthetic agents influence neutrophil function. Our hypothesis was that sevoflurane would inhibit neutrophil apoptosis and consequently influence the postoperative pro-inflammatory state. In order to identify selectively the effect of the anaesthetic agent sevoflurane, we studied patients undergoing minimally stimulating (cataract) surgery randomly allocated to receive either sevoflurane (n=11) or local anaesthesia (n=12). Venous blood samples were taken immediately prior to anaesthesia and at 1, 8 and 24 h thereafter. The rate of neutrophil apoptosis, plasma concentration of cytokines and differential white cell count were measured. The rates of neutrophil apoptosis and plasma concentrations of IL-1β, TNF-α and IL-8 at each time point were similar in the two groups. IL-6 concentrations increased significantly and to a similar extent compared to preanaesthetic levels at 8 and 24 h. This study demonstrates that sevoflurane does not influence the rate of neutrophil apoptosis, cytokine concentrations and neutrophil count following cataract surgery.

Keywords

inflammatory mediatorschemokinesophthalmological surgical procedurescataract extractionimmune systemphagocytesneutrophilscell deathapoptosisimmunityneutrophil activationaanaestheticsinhalationsevoflurane
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 17 , Issue 8 , August 2000 , pp. 474 - 480
Copyright
2000 European Society of Anaesthesiology

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