The early stages of the star formation process are closely related to
the condition of the parent interstellar medium, in particular to the
heating/cooling balance, which itself is a function of ambient
conditions. Important questions such as dust abundance, size
distribution, temperature distribution, fraction of molecular gas,
fraction of dense gas, gas surface density and total amount of gas and
dust require separation of metallicity and radiation effects. The
Magellanic Clouds provide an ideal laboratory to carry out such
studies almost under “controlled conditions”. Although they are
prominent targets for space observatories (Spitzer, Herschel), an
important role remains for large groundbased facilities, such as a
25 m class sub-millimeter telescope on Dome C. Large-scale mapping at
high resolution should be carried out both in the continuum and in
various lines, fully complementing other groundbased and spacebased
observing programs.