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Evolution of some biochemical markers of growth in relation to osteoarticular status in young horses: results of a longitudinal study in three breeds

Published online by Cambridge University Press:  01 February 2007

J P Valette ,
C Robert ,
M P Toquet ,
J M Denoix  and
G Fortier
J P Valette*
Affiliation:
UMR INRA-ENVA, Biomécanique et Pathologie Locomotrice du Cheval, École Nationale Vétérinaire d'Alfort, 7, Avenue du Général-de-Gaulle, 94704 Maisons-Alfort Cedex, France
C Robert
Affiliation:
UMR INRA-ENVA, Biomécanique et Pathologie Locomotrice du Cheval, École Nationale Vétérinaire d'Alfort, 7, Avenue du Général-de-Gaulle, 94704 Maisons-Alfort Cedex, France
M P Toquet
Affiliation:
Laboratoire Départemental Frank Duncombe, 14053 Caen Cedex, France
J M Denoix
Affiliation:
UMR INRA-ENVA, Biomécanique et Pathologie Locomotrice du Cheval, École Nationale Vétérinaire d'Alfort, 7, Avenue du Général-de-Gaulle, 94704 Maisons-Alfort Cedex, France
G Fortier
Affiliation:
Laboratoire Départemental Frank Duncombe, 14053 Caen Cedex, France
*
*Corresponding author: [email protected]
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Abstract

Osteocalcin (OC), bone fraction of alkaline phosphatases (BAP) and hydroxyproline (HOP) are markers of bone cell activity. The kinetics of these markers and the analysis of their variations could be related to the osteoarticular status (OAS) of young horses. The growth of Thoroughbreds, French Trotters and Selle Français horses was followed up to 18 months. Blood samples were taken regularly to measure OC, HOP and BAP by standardized techniques. The OAS was evaluated by radiographic examination of the limbs. Based on radiographic findings, two groups of horses were investigated, with no lesions or severely affected. Analysis of variance was used to detect the effects of age and breed, and OAS on parameters. The logarithmic model was used to determine the kinetics of the markers. A rapid decrease in marker concentrations with age and differences between breed was observed. At birth, BAP, OC and HOP concentrations were significantly higher in normal horses (1910 UI l− 1, 192 ng ml− 1 and 35 mg l− 1, respectively) than in horses with severe lesions (1620 UI l− 1, 149 ng ml− 1 and 24 mg l− 1, respectively). During the first 6 months, OC, HOP and BAP remained lower in severely affected horses.

Keywords

horsedevelopmental orthopaedic diseaseradiographic examinationmarker of bone cell activitylongitudinal study
Type
Research Paper
Information
Equine and Comparative Exercise Physiology , Volume 4 , Issue 1 , February 2007 , pp. 23 - 29
Copyright
Copyright © Cambridge University Press 2007

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