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The association of enterotoxigenic and enteropathogenicEscherichia coli and other enteric pathogens with childhood diarrhoea in Yugoslavia

Published online by Cambridge University Press:  15 May 2009

M. Čobeljić ,
D. Mel ,
B. Arsić ,
Lj. Krstić ,
B. Sokolovski ,
B. Nikolovski ,
E. Šopovski ,
M. Kulauzov  and
S. Kalenić
M. Čobeljić
Affiliation:
Institute of Preventive Medicine, Military Medical Academy, 11000 Belgrade, Yugoslavia
D. Mel
Affiliation:
Institute of Preventive Medicine, Military Medical Academy, 11000 Belgrade, Yugoslavia
B. Arsić
Affiliation:
Institute of Preventive Medicine, Military Medical Academy, 11000 Belgrade, Yugoslavia
Lj. Krstić
Affiliation:
Institute of Preventive Medicine, Military Medical Academy, 11000 Belgrade, Yugoslavia
B. Sokolovski
Affiliation:
Institute of Preventive Medicine, 91000 Skopje, Yugoslavia
B. Nikolovski
Affiliation:
Institute of Preventive Medicine, 91000 Skopje, Yugoslavia
E. Šopovski
Affiliation:
Institute of Preventive Medicine, 91000 Skopje, Yugoslavia
M. Kulauzov
Affiliation:
Institute of Public Health, 21000 Novi Sad, Yugoslavia
S. Kalenić
Affiliation:
Institute of Public Health, 41000 Zagreb, Yugoslavia
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Summary

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The presence of enterotoxigenic and enteropathogenicEscherichia coli (ETEC and EPEC, respectively) was investigated in stool specimens of 1082 preschool children with diarrhoea and in stools of 335 healthy controls in localities in southern Yugoslavia, as well as in 566 children with diarrhoea and in 231 controls living in northern part of the country, during the seasonal peak (August— November) of enteric diseases in 1986.

ETEC were found in 114 (10·5%) children with diarrhoea and in 14 (4·2%) controls (P < 0·001) in the southern part, and in 26 (4·6%) ill children and one (0·4%) well child (P < 0·005) in the northern part of Yugoslavia. EPEC were isolated from stools of 85 (7·9%) children with diarrhoea and of 14 (4·2%) well children (P < 0·05) in localities of southern Yugoslavia, and from 22 (3·9%) ill children and from 10 (4·3%) controls in northern Yugoslavia. Nineteen EPEC strains expressed localized adherence to HEp-2 tissue culture cells; all were isolated from stools of ill children.

In southern Yugoslavia, where other enteropathogens were sought, the most commonly found agents in ill children were shigellae (17·5%), rotavirus (11·8%), ETEC, and EPEC. Potential pathogens were detected in 44·5 % cases of sporadic diarrhoea and in 15·8% controls.

This study revealed that ETEC were associated with acute diarrhoeal disease in Yugoslav preschool children. On the other hand, the diagnosis of EPEC-diarrhoea by routine determination of serogroup established the association of these agents with sporadic diarrhoea only in the 0-2 years age categories in all investigated localities. In the less developed southern part of Yugoslavia bacteria were the predominant causative agents of enteric illness during the seasonal peak of this disease.

Type
Special Article
Information
Epidemiology & Infection , Volume 103 , Issue 1 , August 1989 , pp. 53 - 62
Copyright
Copyright © Cambridge University Press 1989

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