In September 2000, the United Nations (UN) presented the ‘Millennium Development Goals’, a universal political agenda to tackle what it perceived to be the most pressing problems of the coming century. The Millennium Development Goals featured strategies for the fight against extreme poverty, hunger and malnutrition, the improvement of public health, the protection of the environment and the build-up of global developmental structures and partnerships. The achievement of these goals was scheduled, somewhat optimistically, for 2015. The brief time span was intended to illustrate the urgency of the issues and to spur the world into action. Just over a decade after their announcement, and not unexpectedly, the realisation of these goals has proved to be fraught with problems and by now the prospect of their universal achievement has receded into the distant future. Despite huge publicity and public endorsement, the UN's expectations for progress or at least alleviation of major problems are now difficult to maintain as the situation has been exacerbated by global food, economic and financial crises. Comprehensive global success stories, such as the eradication of certain infectious diseases, are rare. As the UN's progress review shows, the close and complex entwinement of these problems within the context of globalisation remains a major challenge.