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New developments in human neurocognition: clinical, genetic, and brain imaging correlates of impulsivity and compulsivity

Published online by Cambridge University Press:  11 February 2014

Naomi A Fineberg ,
Samuel R. Chamberlain ,
Anna E. Goudriaan ,
Dan J. Stein ,
Louk J. M. J. Vanderschuren ,
Claire M. Gillan ,
Sameer Shekar ,
Philip A. P. M. Gorwood ,
Valerie Voon  and
Sharon Morein-Zamir
...Show all authors
Naomi A Fineberg*
Affiliation:
Hertfordshire Partnership NHS University Foundation Trust, Queen Elizabeth II Hospital, Howlands, Welwyn Garden City, Hertfordshire, UK School of Postgraduate Medicine, University of Hertfordshire, Hatfield, Hertfordshire, UK School of Clinical Medicine, Cambridge University, Addenbrooke's Hospital, Cambridge, UK
Samuel R. Chamberlain
Affiliation:
School of Clinical Medicine, Cambridge University, Addenbrooke's Hospital, Cambridge, UK Cambridge and Peterborough NHS Foundation Trust (CPFT), Cambridge, UK
Anna E. Goudriaan
Affiliation:
Department of Psychiatry, Amsterdam Institute for Addiction Research, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands Arkin Mental Health, Amsterdam, The Netherlands
Dan J. Stein
Affiliation:
Department of Psychiatry, University of Cape Town, Cape Town, South Africa
Louk J. M. J. Vanderschuren
Affiliation:
Department of Animals in Science and Society, Division of Behavioural Neuroscience, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
Claire M. Gillan
Affiliation:
Behavioural and Clinical Neuroscience Institute (BCNI), University of Cambridge, Cambridge, UK Department of Psychology, University of Cambridge, Cambridge, UK
Sameer Shekar
Affiliation:
Hertfordshire Partnership NHS University Foundation Trust, Queen Elizabeth II Hospital, Howlands, Welwyn Garden City, Hertfordshire, UK
Philip A. P. M. Gorwood
Affiliation:
INSERM UMR894 (Centre of Psychiatry and Neuroscience), Paris, France Sainte-Anne Hospital, CMME (University Paris Descartes), Paris, France
Valerie Voon
Affiliation:
Behavioural and Clinical Neuroscience Institute (BCNI), University of Cambridge, Cambridge, UK Department of Psychiatry, University of Cambridge, Cambridge, UK
Sharon Morein-Zamir
Affiliation:
Behavioural and Clinical Neuroscience Institute (BCNI), University of Cambridge, Cambridge, UK Department of Psychiatry, University of Cambridge, Cambridge, UK
Damiaan Denys
Affiliation:
Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands The Netherlands Institute for Neuroscience, An Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands
Barbara J. Sahakian
Affiliation:
School of Clinical Medicine, Cambridge University, Addenbrooke's Hospital, Cambridge, UK Behavioural and Clinical Neuroscience Institute (BCNI), University of Cambridge, Cambridge, UK
F. Gerard Moeller
Affiliation:
Departments of Psychiatry and Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA
Trevor W. Robbins
Affiliation:
Behavioural and Clinical Neuroscience Institute (BCNI), University of Cambridge, Cambridge, UK Department of Psychology, University of Cambridge, Cambridge, UK
Marc N. Potenza
Affiliation:
Departments of Psychiatry, Child Study and Neurobiology, Yale School of Medicine, New Haven, Connecticut, USA
*
*Address for correspondence: Prof. Naomi A. Fineberg, Hertfordshire Partnership NHS University Foundation Trust, Queen Elizabeth II Hospital, Howlands, Welwyn Garden City, Hertfordshire, AL7 4HQ, UK. (Email: [email protected])
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Abstract

Impulsivity and compulsivity represent useful conceptualizations that involve dissociable cognitive functions, which are mediated by neuroanatomically and neurochemically distinct components of cortico-subcortical circuitry. The constructs were historically viewed as diametrically opposed, with impulsivity being associated with risk-seeking and compulsivity with harm-avoidance. However, they are increasingly recognized to be linked by shared neuropsychological mechanisms involving dysfunctional inhibition of thoughts and behaviors. In this article, we selectively review new developments in the investigation of the neurocognition of impulsivity and compulsivity in humans, in order to advance our understanding of the pathophysiology of impulsive, compulsive, and addictive disorders and indicate new directions for research.

Keywords

neurocognitioncompulsiveimpulsiveaddictive
Type
Review Articles
Information
CNS Spectrums , Volume 19 , Issue 1 , February 2014 , pp. 69 - 89
Copyright
Copyright © Cambridge University Press 2014 

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Footnotes

This research was funded in part by NIH grants from NIDA (R01 DA 019039, R01 DA018647, P20 DA027844) and NIAAA (RL1 AA017539), the Connecticut State Department of Mental Health and Addictions Services, the Connecticut Mental Health Center, an unrestricted research gift from the Mohegan Sun casino, and the Yale Gambling Center of Research Excellence Award grant from the National Center for Responsible Gaming. The funding agencies did not provide input or comment on the content of the manuscript, and the content of the manuscript reflects the contributions and thoughts of the authors and not necessarily reflect the views of the funding agencies. A.G. was supported by an Addiction Program grant from the Netherlands Organization for Scientific Research (NWO-ZonMW grant 31160003). This research was also supported by the European College of Neuropsychopharmacology (ECNP) Networks Initiative and the International College of Obsessive Compulsive Spectrum Disorders.

We would like to thank Mr. Sameer Shekar for editing and formatting the manuscript and coordinating its submission.

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