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The diagnostic value of plasma N-terminal connective tissue growth factor levels in children with heart failure

Published online by Cambridge University Press:  16 March 2016

Gang Li ,
Xueqing Song ,
Jiyi Xia ,
Jing Li ,
Peng Jia ,
Pengyuan Chen ,
Jian Zhao  and
Bin Liu
Gang Li
Affiliation:
Department of Pediatrics, The Affiliated Hospital of Sichuan Medical University, Sichuan, China
Xueqing Song
Affiliation:
Medical Research Center, The Affiliated Hospital of Sichuan Medical University, Sichuan, China
Jiyi Xia
Affiliation:
Research Center for Drug and Functional Foods of Sichuan Medical University, Sichuan, China
Jing Li
Affiliation:
Department of Emergency, The Affiliated Hospital of Sichuan Medical University, Sichuan, China
Peng Jia
Affiliation:
Department of Pediatrics, The Affiliated Hospital of Sichuan Medical University, Sichuan, China
Pengyuan Chen
Affiliation:
Department of Pediatrics, Sichuan Provincial People’s Hospital, Sichuan, China
Jian Zhao
Affiliation:
Department of Pediatrics, The Affiliated Hospital of Sichuan Medical University, Sichuan, China
Bin Liu*
Affiliation:
Department of Pediatrics, The Affiliated Hospital of Sichuan Medical University, Sichuan, China
*
Correspondence to: B. Liu, Department of Pediatrics, The Affiliated Hospital of Sichuan Medical University, No. 25, Taiping Street, Luzhou, 646000, Sichuan, China. Tel: +86 830 3165613; Fax: +86 830 3163899; E-mail: [email protected]
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Abstract

Objective

The aim of this study was to assess the diagnostic value of plasma N-terminal connective tissue growth factor in children with heart failure.

Methods and results

Plasma N-terminal connective tissue growth factor was determined in 61 children, including 41 children with heart failure, 20 children without heart failure, and 30 healthy volunteers. The correlations between plasma N-terminal connective tissue growth factor levels and clinical parameters were investigated. Moreover, the diagnostic value of N-terminal connective tissue growth factor levels was evaluated. Compared with healthy volunteers and children without heart failure, plasma N-terminal connective tissue growth factor levels were significantly elevated in those with heart failure (p<0.01). N-terminal pro-brain natriuretic peptide and left ventricular end-diastolic dimension were positively correlated with plasma N-terminal connective tissue growth factor levels (r=0.364, p=0.006; r=0.308, p=0.016), whereas there was a negative correlation between left ventricular ejection fraction and plasma N-terminal connective tissue growth factor (r=−0.353, p=0.005). Connective tissue growth factor was significantly correlated with the severity of heart failure (p<0.001). Moreover, addition of connective tissue growth factor to N-terminal pro-brain natriuretic peptide did not significantly increase area under curve for diagnosing heart failure (area under curve difference 0.031, p>0.05), but it obviously improved the ability of diagnosing heart failure in children, as demonstrated by the integrated discrimination improvement (6.2%, p=0.013) and net re-classification improvement (13.2%, p=0.017) indices.

Conclusions

Plasma N-terminal connective tissue growth factor is a promising diagnostic biomarker for heart failure in children.

Keywords

Connective tissue growth factorheart failureN-terminal pro-brain natriuretic peptidebiomarkerchildren
Type
Original Articles
Information
Cardiology in the Young , Volume 27 , Issue 1 , January 2017 , pp. 101 - 108
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Copyright
© Cambridge University Press 2016 

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