Hostname: page-component-cd9895bd7-q99xh Total loading time: 0 Render date: 2024-12-18T12:36:45.409Z Has data issue: false hasContentIssue false
  • English
  • Français

Stem cells and their potential relevance to paediatric cardiology

Published online by Cambridge University Press:  22 March 2006

Frank Pillekamp ,
Michael Reppel ,
Konrad Brockmeier  and
Jürgen Hescheler
Frank Pillekamp
Affiliation:
Paediatric Cardiology, University of Cologne, Cologne, Germany Institute of Neurophysiology, University of Cologne, Cologne, Germany
Michael Reppel
Affiliation:
Institute of Neurophysiology, University of Cologne, Cologne, Germany
Konrad Brockmeier
Affiliation:
Paediatric Cardiology, University of Cologne, Cologne, Germany
Jürgen Hescheler
Affiliation:
Institute of Neurophysiology, University of Cologne, Cologne, Germany
Get access Rights & Permissions [Opens in a new window]

Abstract

Basic scientists, as well as cardiologists, are caught by the idea of curing ischaemic heart disease with cardiac progenitor or stem cells. This short review provides an overview of our current knowledge on the potential use of stem cells for cardiac disease. Since, in infants and children, aetiologies and pathomechanisms of critical cardiac disease are fundamentally different from those in adults, we will also address the question as to whether such young patients could be a therapeutic target at all, and in which respect it may be necessary to view treatment with stem cells from a different stance in the developing organism.

Keywords

Pluripotent stem cellbioprosthesiscardiovascular diseasestherapy
Type
Continuing Medical Education
Information
Cardiology in the Young , Volume 16 , Issue 2 , April 2006 , pp. 117 - 124
Copyright
© 2006 Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Roell W, Lu ZJ, Bloch W, et al. Cellular cardiomyoplasty improves survival after myocardial injury. Circulation 2002; 105: 2435–2441.Google Scholar
Anversa P, Nadal-Ginard B. Myocyte renewal and ventricular remodeling. Nature 2002; 415: 240–243.Google Scholar
Winkel GA, Pederson RA. Fate of the inner cell mass in mouse embryos as studied by microinjection of lineage tracers. Dev Biol 1988; 127: 143–156.Google Scholar
Kolossov E, Lu Z, Drobinskaya I, et al. Identification and characterization of embryonic stem cell-derived pacemaker and atrial cardiomyocytes. FASEB J 2005; 19: 577–579.Google Scholar
Xue T, Cho HC, Akar FG, et al. Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: insights into the development of cell-based pacemakers. Circulation 2005; 111, 11–20.Google Scholar
Rosen MR, Brink PR, Cohen IS, Robinson RB. Genes, stem cells and biological pacemakers. Cardiovasc Res 2004; 64: 12–23.Google Scholar
Sutherland FW, Perry TE, Yu Y, et al. From stem cells to viable autologous semilunar heart valve. Circulation 2005; 111: 2783–2791.Google Scholar
Neuenschwander S, Hoerstrup SP. Heart valve tissue engineering. Transpl Immunol 2004; 12: 359–365.Google Scholar
Hoenig MR, Campbell GR, Rolfe BE, Campbell JH. Tissue-engineered blood vessels: alternative to autologous grafts? Arterioscler Thromb Vasc Biol 2005; 25: 1128–1134.Google Scholar
Sales KM, Salacinski HJ, Alobaid N, Mikhail M, Balakrishnan V, Seifalian AM. Advancing vascular tissue engineering: the role of stem cell technology. Trends Biotechnol 2005; 23: 461–467.Google Scholar
Winitsky SO, Gopal TV, Hassanzadeh S, et al. Adult murine skeletal muscle contains cells that can differentiate into beating cardiomyocytes in vitro. PloS Biol 2005; 3: e87.Google Scholar
Lee N, Thorne T, Losordo DW, Yoon YS. Repair of ischaemic heart disease with novel bone marrow-derived multipotent stem cells. Cell Cycle 2005; 4: 861–864.Google Scholar
Nygren JM, Jovinge S, Breitbach M, et al. Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation. Nat Med 2004; 10: 494–501.Google Scholar
Balsam LB, Wagers AJ, Christensen JL, Kofidis T, Weissman IL, Robbins RC. Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium. Nature 2004: 428: 668–673.Google Scholar
Murry CE, Soonpaa MH, Reinecke H, et al. Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature 2004; 428: 664–668.Google Scholar
Laugwitz KL, Moretti A, Lam J, et al. Postnatal ils 1plus; cardioblasts enter fully differentiated cardiomyocyte lineages. Nature 2005; 433: 647–653.Google Scholar
Menasché P. Skeletal myoblast for cell therapy. Coron Artery Dis 2005; 16: 105–110.Google Scholar
Abraham MR, Henrikson CA, Tung L, et al. Antiarrhythmic engineering of skeletal myoblasts for cardiac transplantation. Circ Res 2005; 22: 159–167.Google Scholar
Leobon B, Garcin I, Menasché P, Vilquin JT, Audinat E, Charpak S. Myoblasts transplanted into rat infarcted myocardium are functionally isolated from their host. Proc Natl Acad Sci USA 2003; 100: 7808–7811.Google Scholar
Quaini F, Urbanek K, Beltrami AP, et al. Chimerism of the transplanted heart. N Engl J Med 2002; 346: 5–15.Google Scholar
Jiang Y, Jahagirdar BN, Reinhardt RL, et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 2002; 418: 41–49.Google Scholar
Pittenger MF, Martin BJ. Mesenchymal stem cells and their potential as cardiac therapeutics. Circ Res 2004; 95: 9–20.Google Scholar
Yoon YS, Lee N, Scadova H. Myocardial regeneration with bone-marrow derived stem cells. Biol Cell 2005; 97: 253–263.Google Scholar
Beltrami AP, Urbanek K, Kajstura J, et al. Evidence that human cardiac myocytes divide after myocardial infarction. N Engl J Med 2001: 344; 1750–1757.Google Scholar
Beltrami AP, Barlucchi L, Torella D, et al. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 2003; 114: 763–776.Google Scholar
Oh H, Bradfute SB, Gallardo TD, et al. Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction. Proc Natl Acad Sci USA 2003; 100: 12313–12318.Google Scholar
Messina E, De Angelis L, Frati G, et al. Isolation and expansion of adult cardiac stem cells from human and murine hearts. Circ Res 2004; 95: 911–921.Google Scholar
Urbanek K, Quaini F, Tasca G, et al. Intense myocytes formation from cardiac stem cells in human cardiac hypertrophy. Proc Natl Acad Sci USA 2003; 100: 10440–10445.Google Scholar
Orlic D, Krajstura J, Chimenti S, et al. Bone marrow cells regenerate infarcted myocardium. Nature 2001; 410: 701–705.Google Scholar
Kajstura J, Rota M, Whang B, et al. Bone marrow cells differentiate in cardiac cell lineages after infarction independently of cell fusion. Circ Res 2005; 96: 127–137.Google Scholar
Wagers AJ, Weissman IL. Plasticity of adult stem cells. Cell 2004; 116: 639–648.Google Scholar
Chen EH, Olson EN. Unveiling the mechanisms of cell-cell fusion. Science 2005; 308: 369–373Google Scholar
Carmago FD, Chambers SM, Goodell MA. Stem cell plasticity: from transdifferentiation to macrophage fusion. Cell Prolif 2004; 37: 55–65.Google Scholar
O'Malley K, Scott EW. Stem cell fusion confusion. Exp Hematol 2004; 32: 131.Google Scholar
Do JT, Scholer HR. Nuclei of embryonic stem cells reprogram somatic cells. Stem Cells 2004; 22: 941–949.Google Scholar
Wollert KC, Meyer GP, Lotz J, et al. Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial. Lancet 2004; 364: 141–148.Google Scholar
Anversa P, Kajstura J. Ventricular myocytes are not terminally differentiated in the adult mammalian heart. Circ Res 1998; 183: 1–4.Google Scholar
Nadal-Ginard B, Kajstura J, Leria A, Anversa P. Myocyte death, growth, and regeneration in cardiac hypertrophy and failure. Circ Res 2003; 92: 139–150.Google Scholar
Spradling A, Drummond-Barbose D, Kai T. Stem cells find their niche. Nature 2001; 414: 98–104.Google Scholar
Cai CL, Liang X, Shi Y, et al. Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart. Dev Cell 2003; 5: 877–889.Google Scholar
Parmacek MS, Epstein JA. Pursuing cardiac progenitors: regeneration redux. Cell 2005; 120: 295–298.Google Scholar
Thomson JA, Iskovitz-Eldor J, Shapiro SS, et al. Embryonic stem cell lines derived from human blastocysts. Science 1998; 282: 1145–1157.Google Scholar
Xu RH, Peck RM, Li DS, Feng X, Ludwig T, Thomson JA. Basic FGF and suppression of BMP signaling sustain undifferentiated proliferation of human ES cells. Nat Methods 2005; 2: 185–190.Google Scholar
Itskovitz-Eldor J, Schuldiner M, Karsenti D, et al. Differentiation of human embryonic stem cells into embryoid bodies compromising the three embryonic germ layers. Mol Med 2000; 6: 88–95.Google Scholar
Reppel M, Boettinger C, Hescheler J. Beta-adrenergic and muscarinic modulation of human embryonic stem cell-derived cardiomyocytes. Cell Physiol Biochem 2004; 14: 187–196.Google Scholar
Kehat I, Khimovich L, Caspi O, et al. Electromechanical integration of cardiomyocytes derived from human embryonic stem cells. Nat Biotechnol 2004; 22: 1282–1289.Google Scholar
Agbulut O, Menot ML, Li Z, et al. Temporal patterns of bone marrow cell differentiation following transplantation in doxorubicin-induced cardiomyopathy. Cardiovasc Res 2003; 58: 451–459.Google Scholar
Wang JF, Yang Y, Wang G, et al. Embryonic stem cells attenuate viral myocarditis in murine model. Cell Transplant 2002; 11: 753–758.Google Scholar
Yoon YS, Park JS, Tkebuchava T, Luedeman C, Losordo DW. Unexpected severe calcification after transplantation of bone marrow cells in acute myocardial infarction. Circulation 2004; 109: 3154–3157.Google Scholar
Maltsev VA, Rohwedel J, Hescheler J, Wobus AM. Embryonic stem cells differentiate in vitro into cardiomyocytes representing sinusnodal, atrial and ventricular cell types. Mech Dev 1993; 44: 41–50.Google Scholar
Gassanov N, Er F, Zgidullin N, Hoppe UC. Endothelin induces differentiation of ANP-EGFP expressing embryonic stem cells towards a pacemaker phenotype. FASEB J 2004; 18: 1710–1712.Google Scholar
Couzin J, Vogel G. Cell therapy. Renovating the heart. Science 2004; 304: 192–194.Google Scholar
Gutstein DE, Danik SB, Lewilton S, et al. Focal gap junction uncoupling and spontaneous ventricular ectopy. Am J Physiol Heart Circ Physiol 2005; 289: H1091–H1098.Google Scholar
Gutstein DE, Morley GE, Tamaddon H, et al. Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin 43. Circ Res 2001; 88: 333–339.Google Scholar
Li L, Xie T. Stem cell niche: structure and function. Annu Rev Cell Dev Biol 2004; [Epub ahead of print]Google Scholar
Bradley JA, Bolton EM, Pedersen RA. Stem cell medicine encounters the immune system. Nat Rev Immunol 2002; 2: 859–871.Google Scholar
Xiao YF, Min JY, Morgan JP. Immunosuppression and xenotransplantation of cells for cardiac repair. Ann Thorac Surg 2004; 77: 737–744.Google Scholar
Drukker M, Benvenisty N. The immunogenicity of human embryonic stem-derived cells. Trends Biotechnol 2004; 22: 136–141.Google Scholar
Aggarwal S, Pittenger MF. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 2005; 105: 1815–1822.Google Scholar
Kim JY, Kim D, Choi I, et al. MHC expression in a human adult stem cell line and its down-regulation by hCMV US gene transfection. Int J Biochem Cell Biol 2005; 37: 69–78.Google Scholar
Hochedlinger K, Jaenisch R. Nuclear transplantation, embryonic stem cells, and the potential for cell therapy. NEJM 2003; 349: 275–286.Google Scholar
Pomerantz J, Blau HM. Nuclear reprogramming: a key to stem cell function in regenerative medicine. Nat Cell Biol 2004; 6: 810–816.Google Scholar
Jaenisch R. Human cloning – the science and ethics of nuclear transplantation. N Engl J Med 2004; 351: 27.Google Scholar
McHugh PR. Zygote and “clonoate” – the ethical use of embryonic stem cells. N Engl J Med 2004; 351: 209–211.Google Scholar
Antoniou M. Embryonic stem cell research. The case against … Nat Med 2001; 7: 396–397.Google Scholar
McLaren A. Ethical and social considerations of stem cell research. Nature 2001; 414: 129–131.Google Scholar
Winston R. Embryonic stem cell research. The case for … Nat Med 2001; 7: 397–399.Google Scholar