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Etoposide-related cardiotoxicity in a child with haemophagocytic lymphohistiocytosis

Published online by Cambridge University Press:  25 February 2010

Heather Escoto ,
Jeremy Ringewald  and
Ram Kalpatthi
Heather Escoto
Affiliation:
Division of Pediatric Hematology and Oncology, Medical University of South Carolina, Charleston, South Carolina, United States of America
Jeremy Ringewald
Affiliation:
Division of Cardiology, Medical University of South Carolina, Charleston, South Carolina, United States of America
Ram Kalpatthi*
Affiliation:
Division of Pediatric Hematology and Oncology, Medical University of South Carolina, Charleston, South Carolina, United States of America
*
Correspondence to: Ram Kalpatthi, MD, Division of Pediatric Hematology Oncology, Children’s Mercy Hospital, 2401 Gillham Road, Kansas City, MO 64108. Tel: 816-234-3265; Fax: 816-855-1700; E-mail: [email protected]
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Abstract

We report a male child with haemophagocytic lymphohistiocytosis who developed myocardial infarction after receiving etoposide. He recovered well with supportive measures and after discontinuation of etoposide. We discuss the possible mechanisms and differential diagnoses of myocardial infarction in our patient.

Keywords

Chemotherapymyocardial infarctionelectrocardiogram
Type
Brief Reports
Information
Cardiology in the Young , Volume 20 , Issue 1 , February 2010 , pp. 105 - 107
Copyright
Copyright © Cambridge University Press 2010

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References

1.Ozben, B, Kurt, R, Oflaz, H, et al. Acute anterior myocardial infarction after chemotherapy for testicular seminoma in a young patient. Clin Appl Thromb Hemost 2007; 13: 439–442.CrossRefGoogle ScholarPubMed
2.Zeymer, U, Neuhaus, KL. Acute coronary thrombosis and myocardial ischemia following chemotherapy of Hodgkin’s disease. Onkologie 1990; 13: 221–224.Google ScholarPubMed
3.Airey, CL, Dodwell, DJ, Joffe, JK, Jones, WG. Etoposide-related myocardial infarction. Clin Oncol (R Coll Radiol) 1995; 7: 135.Google Scholar
4.Aisner, J, Van Echo, DA, Whitacre, M, Wiernik, PH. A phase I trial of continuous infusion VP16-213 (etoposide). Cancer Chemother Pharmacol 1982; 7: 157–160.Google Scholar
5.Schecter, JP, Jones, SE, Jackson, RA. Myocardial infarction in a 27-year-old woman: possible complication of treatment with VP-16-213 (NSC-141540), mediastinal irradiation, or both. Cancer Chemother Rep 1975; 59: 887–888.Google Scholar
6.Schwarzer, S, Eber, B, Greinix, H, Lind, P. Non-Q-wave myocardial infarction associated with bleomycin and etoposide chemotherapy. Eur Heart J 1991; 12: 748–750.Google Scholar
7.Takeoka, Y, Nakamae, M, Nakamae, H, et al. Two cases of ampulla (takotsubo-shaped) cardiomyopathy associated with hemophagocytic lymphohistiocytosis. Acta Haematol 2007; 117: 205–210.CrossRefGoogle ScholarPubMed