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Early signs that predict later haemodynamically significant patent ductus arteriosus

Published online by Cambridge University Press:  31 March 2015

Defne Engür ,
Murat Deveci  and
Münevver K. Türkmen
Defne Engür*
Affiliation:
Department of Neonatology, Adnan Menderes University, Aydın, Turkey
Murat Deveci
Affiliation:
Department of Pediatric Cardiology, Department of Pediatrics, Adnan Menderes University, Aydın, Turkey
Münevver K. Türkmen
Affiliation:
Department of Neonatology, Adnan Menderes University, Aydın, Turkey
*
Correspondence to: Dr D. Engür, Adnan Menderes University Department of Neonatology, Aytepe Mevki, 32100, Aydın, Turkey. Tel: +90 256 444 12 56; Fax: +90 256 214 40 86; E-mail: [email protected]
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Abstract

Objective

Our aim was to determine the optimal cut-off values, sensitivity, specificity, and diagnostic power of 12 echocardiographic parameters on the second day of life to predict subsequent ductal patency.

Methods

We evaluated preterm infants, born at ⩽32 weeks of gestation, starting on their second day of life, and they were evaluated every other day until ductal closure or until there were clinical signs of re-opening. We measured transductal diameter; pulmonary arterial diastolic flow; retrograde aortic diastolic flow; pulsatility index of the left pulmonary artery and descending aorta; left atrium and ventricle/aortic root ratio; left ventricular output; left ventricular flow velocity time integral; mitral early/late diastolic flow; and superior caval vein diameter and flow as well as performed receiver operating curve analysis.

Results

Transductal diameter (>1.5 mm); pulmonary arterial diastolic flow (>25.6 cm/second); presence of retrograde aortic diastolic flow; ductal diameter by body weight (>1.07 mm/kg); left pulmonary arterial pulsatility index (⩽0.71); and left ventricle to aortic root ratio (>2.2) displayed high sensitivity and specificity (p<0.0001; area under the curve>0.9). Parameters with moderate sensitivity and specificity were as follows: left atrial to aortic root ratio; left ventricular output; left ventricular flow velocity time integral; and mitral early/late diastolic flow ratio (p<0.05; area under the curve 0.7–0.88). Descending aortic pulsatility index and superior caval vein diameter and flow (p>0.05) had low diagnostic value.

Conclusion

Left pulmonary arterial pulsatility index, left ventricle/aortic root ratio, and ductal diameter by body weight are useful adjuncts offering a broader outlook for predicting ductal patency.

Keywords

Echocardiographynewbornpatent ductus arteriosusneonatal intensive care unitreceiver operating characteristic curve method
Type
Original Articles
Information
Cardiology in the Young , Volume 26 , Issue 3 , March 2016 , pp. 439 - 445
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Copyright
© Cambridge University Press 2015 

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