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A case of parvovirus B19-induced pure red cell aplasia in a child following heart transplant

Published online by Cambridge University Press:  21 February 2014

Eoin Kelleher ,
Corrina McMahon  and
Colin J. McMahon
Eoin Kelleher
Affiliation:
Department of Paediatric Cardiology, Our Lady’s Children’s Hospital, Crumlin, Dublin, Ireland
Corrina McMahon
Affiliation:
Department of Paediatric Haematology, Our Lady’s Children’s Hospital, Crumlin, Dublin, Ireland
Colin J. McMahon*
Affiliation:
Department of Paediatric Cardiology, Our Lady’s Children’s Hospital, Crumlin, Dublin, Ireland
*
Correspondence to: Dr C. J. McMahon, FRCPI, Cardiac Department, Our Lady’s Children’s Hospital, Crumlin, Dublin 12, Ireland; Tel: +01 4096160; Fax: +01 4096181; E-mail: [email protected]
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Abstract

We describe a case of an 11-year-old boy who underwent orthotopic heart transplant for dilated cardiomyopathy. He developed a normocytic, normochromic anaemia with a low reticulocyte count 1 month after transplant. A bone marrow biopsy was performed, which showed a mildly hypocellular bone marrow with few red blood cell precursors with giant pro-erythroblasts indicative of a pure red cell aplasia. Parvovirus B19 polymerase chain reaction in the blood was positive 2 months after transplant. Intravenous immunoglobulin administration resulted in a resolution of the anaemia over several months. Unexplained pure red cell aplasia in immunosuppressed patients should alert one to the possibility of parvovirus B19 infection.

Keywords

Heart transplantanaemiaparvovirus B19red cell aplasia
Type
Brief Reports
Information
Cardiology in the Young , Volume 25 , Issue 2 , February 2015 , pp. 373 - 375
Copyright
© Cambridge University Press 2014 

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