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Aortic stenosis in a patient with Hurler's syndrome after bone marrow transplantation

Published online by Cambridge University Press:  25 January 2011

Naruhito Watanabe ,
Petros V. Anagnostopoulos  and
Anthony Azakie
Naruhito Watanabe
Affiliation:
Department of Surgery, Division of Pediatric Cardiac Surgery, UCSF Benioff Children's Hospital, University of California San Francisco, San Francisco, California, United States of America
Petros V. Anagnostopoulos
Affiliation:
Department of Surgery, Division of Pediatric Cardiac Surgery, UCSF Benioff Children's Hospital, University of California San Francisco, San Francisco, California, United States of America
Anthony Azakie*
Affiliation:
Department of Surgery, Division of Pediatric Cardiac Surgery, UCSF Benioff Children's Hospital, University of California San Francisco, San Francisco, California, United States of America
*
Correspondence to: Dr A. Azakie, MD, UCSF Benioff Children's Hospital, University of California San Francisco, 513 Parnassus Avenue, San Francisco, California 94143, United States of America. Tel: 415 476 3501, Fax: 415 476 9678; E-mail: [email protected]
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Abstract

We describe a case of severe aortic stenosis in a 16-year-old male with Hurler's syndrome who had prior bone marrow transplantation. The excised aortic valve leaflets showed characteristic pathologic findings of Hurler's syndrome. This is the first case report of aortic valve replacement in a patient with Hurler's syndrome treated with bone marrow transplantation that demonstrates progression of the aortic valve disease despite treatment.

Keywords

Mucopolysaccharidosisaortic valve replacementvalvular disease
Type
Brief Reports
Information
Cardiology in the Young , Volume 21 , Issue 3 , June 2011 , pp. 349 - 350
Copyright
Copyright © Cambridge University Press 2011

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