Hostname: page-component-586b7cd67f-t8hqh Total loading time: 0 Render date: 2024-11-23T20:21:29.326Z Has data issue: false hasContentIssue false

Monoclonal Antibody Therapy and Progressive Multifocal Leukoencephalopathy

Published online by Cambridge University Press:  02 December 2014

Alan C. Jackson*
Affiliation:
University of Manitoba, Winnipeg, Manitoba, Canada
Rights & Permissions [Opens in a new window]

Abstract

Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Editorial
Copyright
Copyright © The Canadian Journal of Neurological 2011

References

1.Engsig, FN, Hansen, AB, Omland, LH, et al.Incidence, clinical presentation, and outcome of progressive multifocal leukoencephalopathy in HIV-infected patients during the highly active antiretroviral therapy era: a nationwide cohort study. J Infect Dis. 2009;199:7783.Google Scholar
2.Rice, GP, Hartung, HP, Calabresi, PA.Anti-alpha4 integrin therapy for multiple sclerosis: mechanisms and rationale. Neurology. 2005;64:1336–42.CrossRefGoogle ScholarPubMed
3.Krumbholz, M, Meinl, I, Kumpfel, T, Hohlfeld, R, Meinl, E.Natalizumab disproportionately increases circulating pre-B and B cells in multiple sclerosis. Neurology. 2008;71:1350–4.Google Scholar
4.O’Connor, PW.Use of natalizumab in multiple sclerosis patients. Can J Neurol Sci. 2010;37:98104.Google Scholar
5.Adelman, B, Sandrock, A, Panzara, MA.Natalizumab and progressive multifocal leukoencephalopathy. N Engl J Med. 2005;353:432–3.CrossRefGoogle ScholarPubMed
6.Langer-Gould, A, Atlas, SW, Green, AJ, Bollen, AW, Pelletier, D.Progressive multifocal leukoencephalopathy in a patient treated with natalizumab. N Engl J Med. 2005;353:375–81.CrossRefGoogle Scholar
7.Kleinschmidt-DeMasters, BK, Tyler, KL.Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon beta-1a for multiple sclerosis. N Engl J Med. 2005;353:369–74.CrossRefGoogle ScholarPubMed
8.Van, AG, Van, RM, Sciot, R, et al.Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn’s disease. N Engl J Med. 2005;353:362–8.Google Scholar
9.Clifford, DB, De Luca, A, Simpson, DM, Arendt, G, Giovannoni, G, Nath, A.Natalizumab-associated progressive multifocal leukoencephalopathy in patients with multiple sclerosis: lessons from 28 cases. Lancet Neurol. 2010;9:438–46.Google Scholar
10.Yousry, TA, Major, EO, Ryschkewitsch, C, et al.Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy. N Engl J Med. 2006;354:924–33.Google Scholar
11.Biogen Idec (2011) Tysabri, PML monthly update - May 2011.Google Scholar
12.Carson, KR, Evens, AM, Richey, EA, et al.Progressive multifocal leukoencephalopathy after rituximab therapy in HIV-negative patients: a report of 57 cases from the Research on Adverse Drug Events and Reports project. Blood. 2009;113:4834–40.CrossRefGoogle ScholarPubMed
13.Sandrock, A, Hotermans, C, Richman, S, et al.Risk stratification for progressive multifocal leukoencephaloathy (PML) in MS patients: role of prior immunosuppressant use, natalizumab-treatment duration, and anti-JCV antibody status (Abstract). Neurology. 2011; 76(Suppl 4):A278.Google Scholar
14.Tan, CS, Koralnik, IJ.Progressive multifocal leukoencephalopathy and other disorders caused by JC virus: clinical features and pathogenesis. Lancet Neurol. 2010;9:425–37.Google Scholar
15.Keene, DL, Legare, C, Taylor, E, Gallivan, J, Cawthorn, GM, Vu, D.Monoclonal antibodies and progressive multifocal leukoencephalopathy. Can J Neurol Sci. 2011;38(4):565–71.Google Scholar
16.Korman, BD, Tyler, KL, Korman, NJ.Progressive multifocal leukoencephalopathy, efalizumab, and immunosuppression: a cautionary tale for dermatologists. Arch Dermatol. 2009;145: 937–42.Google Scholar
17.Gorelik, L, Lerner, M, Bixler, S, et al.Anti-JC virus antibodies: implications for PML risk stratification. Ann Neurol. 2010;68: 295303.Google Scholar
18.Chen, Y, Bord, E, Tompkins, T, et al.Asymptomatic reactivation of JC virus in patients treated with natalizumab. N Engl J Med. 2009;361:1067–74.Google Scholar
19.Jilek, S, Jaquiery, E, Hirsch, HH, et al.Immune responses to JC virus in patients with multiple sclerosis treated with natalizumab: a cross-sectional and longitudinal study. Lancet Neurol. 2010;9: 264–72.Google Scholar