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Immune Cell Infiltrates in Atypical Teratoid/Rhabdoid Tumors

Published online by Cambridge University Press:  02 December 2014

Jian-Qiang Lu ,
Beverly A. Wilson ,
V. Wee Yong ,
Jeffrey Pugh  and
Vivek Mehta
Jian-Qiang Lu*
Affiliation:
Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton
Beverly A. Wilson
Affiliation:
Department of Pediatrics, University of Alberta, Edmonton
V. Wee Yong
Affiliation:
Department of Oncology and Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
Jeffrey Pugh
Affiliation:
Department of Surgery, University of Alberta, Edmonton
Vivek Mehta
Affiliation:
Department of Surgery, University of Alberta, Edmonton
*
Neuropathology Section, Department of Laboratory Medicine & Pathology, 5B2.24 WCM Health Sciences Centre, University of Alberta, 8440-112 Street, Edmonton, Alberta t6G 2B7, Canada. Email: [email protected]
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Abstract

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Objective:

Atypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant tumor of the central nervous system. Its pathogenesis remains unknown. Like glioblastomas, AT/RTs contain brain cancer stem cells (CSCs) that suppress the immunity of patients and are resistant to conventional chemotherapy and radiation therapy. Considerable infiltration of immune cells, including macrophages/microglia, dendritic cells and T-cells, has been noted in glioblastomas, which correlates with poor prognosis. The present study examines the significance of infiltrating immune cells in four cases of AT/RT; including one associated with an autoimmune disease, Henoch-Schonlein purpura.

Methods:

Tumor tissues from four patients with AT/RT were analyzed and compared with those from four patients with glioblastomas. The frequency of immune cells, including CD68+, CD4+, and CD8+ cells, was assessed by scoring for statistical analysis.

Results:

The infiltration of immune cells was identified in the case of AT/RT associated with HSP and three other cases of infratentorial AT/RTs. Moderate infiltration of CD68+ macrophages/microglia and CD4+ cells was noted in AT/RTs with no significant difference from that in glioblastomas (p > 0.05). However, the infiltration of CD8+ T-cells was significantly higher in AT/RTs than that in glioblastomas (p < 0.05); CD4+/CD8+ ratio was significantly lower in AT/RTs than that in glioblastomas (p < 0.05). In addition, eosinophils were found in all AT/RTs, but not in glioblastomas.

Conclusions:

These findings suggest an immune microenvironment of AT/RTs with more immune effectors than glioblastomas. Our observation contributes to understanding the growth environment of AT/RTs for which adjuvant immunotherapy may be potentially beneficial.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 39 , Issue 5 , September 2012 , pp. 605 - 612
Copyright
Copyright © The Canadian Journal of Neurological 2012

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