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Gliomas in Families

Published online by Cambridge University Press:  18 September 2015

Y. Ikizler ,
D.J. van Meyel ,
D.A. Ramsay ,
G.L. Abdallah ,
R.M. Allaster ,
D.R. Macdonald ,
W.K. Cavenee  and
J.G. Cairncross
Y. Ikizler
Affiliation:
Departments of Oncology (Y.I., D.J.V.M., D.R.M., J.G.C.), Clinical Neurological Sciences (D.A.R., D.R.M., J.G.C.) and Pathology (D.A.R.), University of Western Ontario and London Regional Cancer Centre (G.L.A., R.M.A., D.R.M., J.G.C.), London; Ludwig Institute for Cancer Research (W.K.C.), San Diego Branch, San Diego
D.J. van Meyel
Affiliation:
Departments of Oncology (Y.I., D.J.V.M., D.R.M., J.G.C.), Clinical Neurological Sciences (D.A.R., D.R.M., J.G.C.) and Pathology (D.A.R.), University of Western Ontario and London Regional Cancer Centre (G.L.A., R.M.A., D.R.M., J.G.C.), London; Ludwig Institute for Cancer Research (W.K.C.), San Diego Branch, San Diego
D.A. Ramsay
Affiliation:
Departments of Oncology (Y.I., D.J.V.M., D.R.M., J.G.C.), Clinical Neurological Sciences (D.A.R., D.R.M., J.G.C.) and Pathology (D.A.R.), University of Western Ontario and London Regional Cancer Centre (G.L.A., R.M.A., D.R.M., J.G.C.), London; Ludwig Institute for Cancer Research (W.K.C.), San Diego Branch, San Diego
G.L. Abdallah
Affiliation:
Departments of Oncology (Y.I., D.J.V.M., D.R.M., J.G.C.), Clinical Neurological Sciences (D.A.R., D.R.M., J.G.C.) and Pathology (D.A.R.), University of Western Ontario and London Regional Cancer Centre (G.L.A., R.M.A., D.R.M., J.G.C.), London; Ludwig Institute for Cancer Research (W.K.C.), San Diego Branch, San Diego
R.M. Allaster
Affiliation:
Departments of Oncology (Y.I., D.J.V.M., D.R.M., J.G.C.), Clinical Neurological Sciences (D.A.R., D.R.M., J.G.C.) and Pathology (D.A.R.), University of Western Ontario and London Regional Cancer Centre (G.L.A., R.M.A., D.R.M., J.G.C.), London; Ludwig Institute for Cancer Research (W.K.C.), San Diego Branch, San Diego
D.R. Macdonald
Affiliation:
Departments of Oncology (Y.I., D.J.V.M., D.R.M., J.G.C.), Clinical Neurological Sciences (D.A.R., D.R.M., J.G.C.) and Pathology (D.A.R.), University of Western Ontario and London Regional Cancer Centre (G.L.A., R.M.A., D.R.M., J.G.C.), London; Ludwig Institute for Cancer Research (W.K.C.), San Diego Branch, San Diego
W.K. Cavenee
Affiliation:
Departments of Oncology (Y.I., D.J.V.M., D.R.M., J.G.C.), Clinical Neurological Sciences (D.A.R., D.R.M., J.G.C.) and Pathology (D.A.R.), University of Western Ontario and London Regional Cancer Centre (G.L.A., R.M.A., D.R.M., J.G.C.), London; Ludwig Institute for Cancer Research (W.K.C.), San Diego Branch, San Diego
J.G. Cairncross*
Affiliation:
Departments of Oncology (Y.I., D.J.V.M., D.R.M., J.G.C.), Clinical Neurological Sciences (D.A.R., D.R.M., J.G.C.) and Pathology (D.A.R.), University of Western Ontario and London Regional Cancer Centre (G.L.A., R.M.A., D.R.M., J.G.C.), London; Ludwig Institute for Cancer Research (W.K.C.), San Diego Branch, San Diego
*
London Regional Cancer Centre, 790 Commissioners Road, East, London, Ontario, Canada N6A 4L6
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Abstract:

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This is a descriptive study of 19 families with glial tumors. Twelve were identified prospectively from 178 consecutive, unrelated adults and children with newly diagnosed gliomas seen at a regional cancer center between 01 Jan 89 and 31 Mar 91 (6.7%). There were 45 affected members (42 confirmed); 30 males, 15 females, ages 4 months-78 years (median, 44.5 years; mean, 38.9 years). Two families had four affected members, three families had three, and the others two. All confirmed tumors were supratentorial and all, save one, contained an astrocytic element. Three additional members of two families had other brain or neuroectodermal tumors. These families were not unusually cancer prone and did not appear to have neurofibromatosis, tuberous sclerosis, or colonic polyposis. There was no consistent pattern of inheritance.

Type
Articles
Information
Canadian Journal of Neurological Sciences , Volume 19 , Issue 4 , November 1992 , pp. 492 - 497
Copyright
Copyright © Canadian Neurological Sciences Federation 1992

References

REFERENCES

1.Bakshi, R, Ducatman, AM, Hochberg, FH.Glioblastomas in New England opthalmologists (letter). N Eng J Med 1991; 324: 1440–1441.Google Scholar
2.Hochberg, F, Toniolo, P, Cole, P.Head trauma and seizures as risk factors of glioblastoma. Neurology 1984; 34: 1511–1514.CrossRefGoogle ScholarPubMed
3.Lossignol, D, Grossman, SA, Sheidler, VR, Griffin, CA, Piantadosi, S.Familial clustering of malignant astrocytomas. J Neuro-oncol 1990; 9: 139–145.CrossRefGoogle ScholarPubMed
4.Duhaime, AC, Bunin, G, Sutton, L, Rorke, LB, Packer, RJ.Simultaneous presentation of glioblastoma multiforme in siblings two and five years old: case report. Neurosurgery 1989; 24: 434–439.CrossRefGoogle ScholarPubMed
5.Heuch, I, Blom, GP.Glioblastoma multiforme in three family members, including a case of true multicentricity. J Neurol 1986; 233: 142–144.CrossRefGoogle ScholarPubMed
6.Maroun, FB, Jacob, JC, Heneghan, WD, Managan, MA, Russell, NA, et al. Familial intracranial gliomas. Surg Neurol 1984; 22: 76–78.CrossRefGoogle ScholarPubMed
7.Tijssen, CC, Hairpin, MR, Endtz, LJ.Familial brain tumors. In: Martinus Nijhoff, , ed. Developments in Oncology. Boston: 1982; 442–3.Google Scholar
8.Von Motz, ID, Bots, G, Endtz, LJ.Astrocytoma in three sisters. Neurology 1977; 27: 1038–1041.CrossRefGoogle ScholarPubMed
9.Isamat, F, Miranda, AM, Bartumeus, F, Prat, J.Genetic implications of familial brain tumors. J Neurosurg 1974; 41: 573–575.CrossRefGoogle ScholarPubMed
10.Kaufman, HH, Brisman, R.Familial gliomas: report of four cases. J Neurosurg 1972; 37: 110–112.CrossRefGoogle ScholarPubMed
11.Armstrong, RM, Hanson, CW.Familial gliomas. Neurology 1969; 19: 1061–1063.CrossRefGoogle ScholarPubMed
12.Kjellin, K, Muller, R, Astrom, KE.The occurrence of brain tumors in several members of a family. J Neuropathol Exp Neurol 1960; 19: 528–537.CrossRefGoogle ScholarPubMed
13.Munslow, RA, Hill, AH.Multiple occurrences of gliomas in a family. J Neurosurg 1955; 12: 646–650.CrossRefGoogle ScholarPubMed
14.Parkinson, D, Hall, CW.Oligodendrogliomas, . Simultaneous appearance in frontal lobes of siblings. J Neurosurg 1962; 19: 424–426.CrossRefGoogle ScholarPubMed
15.Joughin, JL.Coincident tumor of the brain in twins. Arch Neurol Psychiatr 1928; 19: 948–950.Google Scholar
16.Fairburn, B, Urich, H.Malignant gliomas occurring in identical twins. J Neurol Neurosurg Psychiatry 1971; 34: 718–722.CrossRefGoogle ScholarPubMed
17.Turcot, J, Despres, JP, St. Pierre, F.Malignant tumors of the central nervous system associated with familial polyposis of the colon. Report of two cases. Dis Colon Rectum 1959; 2: 465–468.CrossRefGoogle ScholarPubMed
18.Mastronardi, L, Ferrante, L, Lunardi, P, et al. Association between neuroepithelial tumor and multiple intestinal polyposis (Turcot’s syndrome): report of a case and critical analysis of the literature. Neurosurgery 1991; 28: 449–452.CrossRefGoogle ScholarPubMed
19.Li, FP, Fraumeni, JF, Mulvihill, JJ, Blattner, WA, Dreyfus, MG, et al. A cancer family syndrome in twenty-four kindreds. Cancer Res 1988; 48: 5358–5362.Google ScholarPubMed
20.Malkin, D, Li, FP, Strong, LC, et al. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas and other neoplasms. Science 1990; 250: 1233–1238.CrossRefGoogle Scholar
21.Srivastav, S, Zou, Z, Pirollo, K, Blattner, W, Chang, EH.Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome. Nature 1990; 348: 747–749.CrossRefGoogle Scholar
22.Fearon, ER, Vogelstein, B.A genetic model for colorectal tumorigenesis. Cell 1990; 61: 757–767.CrossRefGoogle ScholarPubMed
23.Mikkelson, T, Cairncross, JG, Cavenee, WK.Genetics of the malignant progression of astrocytoma. J Cell Biochem 1991; 46: 3–8.CrossRefGoogle Scholar
24.Hochberg, F, Toniolo, P, Cole, P.Nonoccupational risk indicators of glioblastoma in adults. J Neuro-oncol 1990; 8: 55–60.CrossRefGoogle ScholarPubMed
25.Martin, GM, Schellenberg, GD, Wijsman, EM.Bird TD. Dominant susceptibility genes. Nature 1990; 347: 124.CrossRefGoogle ScholarPubMed
26.Lee, W-H, Bookstein, R, Lee EY-HP. Studies on the human retinoblastoma susceptibility gene. J Cell Biol 1988; 212: 15–29.Google Scholar
27.Sakai, T, Ohtani, N, McGee, TL, Robbins, PD, Dryja, TP.Oncogenic germ-line mutations in Spi and ATF sites in the human retinoblastoma gene. Nature 1991; 353: 83–86.CrossRefGoogle Scholar