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Complications in MS Patients after CCSVI Procedures Abroad (Calgary, AB)

Published online by Cambridge University Press:  18 February 2016

Jodie M. Burton ,
Katayoun Alikhani ,
Mayank Goyal ,
Fiona Costello ,
Chris White ,
David Patry ,
Robert Bell  and
Michael D. Hill
Jodie M. Burton*
Affiliation:
Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
Katayoun Alikhani
Affiliation:
Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
Mayank Goyal
Affiliation:
Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada Department of Radiology, University of Calgary, Calgary, Alberta, Canada
Fiona Costello
Affiliation:
Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
Chris White
Affiliation:
Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
David Patry
Affiliation:
Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
Robert Bell
Affiliation:
Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
Michael D. Hill
Affiliation:
Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada
*
Health Sciences Centre, Room 1007, 3330 Hospital Drive NW, Calgary, Alberta, T2N 4N1, Canada
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Abstract:

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Background:

The “chronic cerebrospinal venous insufficiency” or “CCSVI” hypothesis, namely that multiple sclerosis (MS) is caused by abnormalities in the azygous and internal jugular veins with subsequent alterations in venous hemodynamics in the central nervous system, has been a dominant topic in MS care in Canada over the past year. Although there is no methodologically rigorous evidence to support this hypothesis presently, a considerable number of MS patients have undergone endovascular CCSVI procedures. Such procedures include angioplasty or stent placement in jugular and azygous veins. The safety and efficacy of these procedures is unknown, but not without risk.

Methods:

Chart and patient review of five patients with confirmed MS followed in Calgary were undertaken after patients came to medical attention by referral or admission secondary to complications believed to be associated with CCSVI procedures.

Results:

Complications upon investigation and review included internal jugular vein stent thrombosis, cerebral sinovenous thrombosis, stent migration, cranial nerve injury and injury associated with venous catheterization.

Conclusions:

As the debate about CCSVI and its relationship to MS continues, the complications and risks associated with venous stenting and angioplasty in jugular and azygous veins are becoming clearer. As increasing numbers of MS patients are seeking such procedures, these five cases represent the beginning of a wave of complications for which standardized care guidelines do not exist. Our experience and that of our colleagues will be used to develop guidelines and strategies to monitor and manage these patients as their numbers increase.

Type
Original Article
Information
Canadian Journal of Neurological Sciences , Volume 38 , Issue 5 , September 2011 , pp. 741 - 746
Copyright
Copyright © Canadian Neurological Sciences Federation 2011

References

1.Zamboni, P, Galeotti, R, Menegatti, E, et al.A prospective open-label study of endovascular treatment of chronic cerebrospinal venous insufficiency. J Vase Surg. 2009;50:1348–58.CrossRefGoogle ScholarPubMed
2.Zamboni, P, Galeotti, R, Menegatti, E, et al.Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis. J Neurol Neurosurg Psychiatry. 2009;80:392–9.CrossRefGoogle ScholarPubMed
3.Khan, O, Filippi, M, Freedman, M, et al.Chronic cerebrospinal venous insufficiency and multiple sclerosis. Ann Neurol. 2010; 67:286–90.CrossRefGoogle ScholarPubMed
4.Doepp, F, Friedmann, P, Valdueza, JM, et al.No cerebrocervical venous congestion in patients with multiple sclerosis. Ann Neurol. 2010;68:173–83.CrossRefGoogle ScholarPubMed
5.Sundstrom, P, Whalin, A, Ambarki, K, et al.Venous and cerebrospinal fluid flow in multiple sclerosis: A case-control study. Ann Neurol. 2010;68:255–9.CrossRefGoogle ScholarPubMed
6.Wattjes, MP, van Oosten, BW, de Graaf, WL, et al.No association of abnormal cranial venous drainage with multiple sclerosis: a magnetic resonance venography and flow-quantification study. J Neurol Neurosurg Psychiatry. Epub 2010 Oct 27Google ScholarPubMed
7.Baracchini, C, Perini, P, Calabrese, M, Causin, F, Rinaldi, F, Gallo, P.No evidence of chronic cerebrospinal venous insufficiency at multiple sclerosis onset. Ann Neurol. 2011;69(l):90–9.CrossRefGoogle ScholarPubMed
8.Meyer-Schwickerath, R, Haug, C, Hacker, A, et al.Intracranial venous pressure is normal in patients with multiple sclerosis. Mult Scler. 2011 May;17(5):637–8. Epub 2011 Jan 12.CrossRefGoogle ScholarPubMed
9.del Pilar Cortes Nino, M, Tampieri, D, Melancon, D.Endovascular venous procedures for multiple sclerosis. Mult Scler. 2010;16(7):771–2.CrossRefGoogle Scholar
10.Ludyga, T, Kazibudzki, M, Simka, M, et al.Endovascular treatment for chronic cerebrospinal venous insufficiency: is the procedure safe? Phlebology. 2010;25(6): 286–95.CrossRefGoogle Scholar
11.Samson, K.Experimental multiple Sclerosis vascular shunting procedure halted at Stanford. Ann Neurol. 2010;67(1):A13–15.Google Scholar