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Cerebrospinal Fluid and Blood Thiamine Concentrations in Phenytoin-Treated Epileptics

Published online by Cambridge University Press:  18 September 2015

M.I. Botez ,
Claude Joyal ,
Urs Maag  and
Jocelyne Bachevalier
M.I. Botez*
Affiliation:
Service of Neurology, Hôtel-Dieu Hospital and Clinical Research Institute of Montreal and Department of Computer Sciences and Operation Research, University of Montreal
Claude Joyal
Affiliation:
Service of Neurology, Hôtel-Dieu Hospital and Clinical Research Institute of Montreal and Department of Computer Sciences and Operation Research, University of Montreal
Urs Maag
Affiliation:
Service of Neurology, Hôtel-Dieu Hospital and Clinical Research Institute of Montreal and Department of Computer Sciences and Operation Research, University of Montreal
Jocelyne Bachevalier
Affiliation:
Service of Neurology, Hôtel-Dieu Hospital and Clinical Research Institute of Montreal and Department of Computer Sciences and Operation Research, University of Montreal
*
Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Québec H2W 1R7, Canada
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Summary:

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Thiamine and folate levels in blood and cerebrospinal fluid (CSF) were determined by microbiological assays in 23 control subjects and 11 phenytoin-treated epileptics. There was no significant difference between the two groups for serum and CSF folate levels. There was, however, a statistically significant difference between the groups for both whole blood thiamine and CSF thiamine levels. Epileptic patients being treated with phenytoin had lower values than control subjects (p < 0.001)

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 9 , Issue 1 , February 1982 , pp. 37 - 39
Copyright
Copyright © Canadian Neurological Sciences Federation 1982

References

REFERENCES

Baker, H. and Frank, O. (1968). In: Clinical Vitaminology, Inter-science Publishers, J. Wiley and Sons, New York, pp. 7–21.Google Scholar
Birket-Smith, E. and Krogh, E. (1971). Motor nerve conduction velocity during di-phenylhydantoin intoxication. Acta Neurol. Scand., 47, 265–271.CrossRefGoogle Scholar
Botez, M.I., Young, S.N., Bachevalier, J. and Gauthier, S. (1979). Folate deficiency and decreased brain 5-hydroxytryptamine synthesis in man and rat. Nature, 278, 182–183.Google ScholarPubMed
Botez, M.I., Peyronnard, J.M., Bachevalier, J. and Charron, L. (1978). Polyneuropathy and folate deficiency. Arch. Neurol., 35, 581–584.CrossRefGoogle ScholarPubMed
Bradley, I.V. (1968). In: Distribution-Free Statistical Tests Prentice-Hall, Englewood Cliffs, Section 5.8.Google Scholar
Brin, M. (1962). Erythrocyte transketolase in early thiamine deficiency. Ann. N.Y. Acad. Sci., 98, 528–531.CrossRefGoogle ScholarPubMed
Chokroverty, S. and Sayeed, Z.A. (1975). Motor nerve conduction study in patients on diphenylhydantoin therapy. J. Neurol. Neurosurg. Psychiat. 38, 1235–1239.CrossRefGoogle ScholarPubMed
Eisen, A.A., Woods, J.F. and Sherwin, A.L. (1974). Peripheral nerve-function in long-term therapy with diphenylhydantoin. Neurology 24, 411–417.CrossRefGoogle ScholarPubMed
Figueroa, M.A., Johnson, R.H., Lambie, D.G. and Shakir, R.A. (1980). The role of folate deficiency in the development of peripheral neuropathy caused by anticonvulsants. J. Neurol. Sci., 48, 315–323.CrossRefGoogle Scholar
Frenkel, E.P., McCall, M.S. and Sheehan, R.G. (1973). Cerebrospinal fluid folate and vitamine B12 in anticonvulsant induced megaloblastosis. J. Lab. Clin. Med., 81, 105–115.Google Scholar
Ghatak, N.R., Santoso, R.A. and McKinney, W.M. (1976). Cerebellar degeneration following long-term phenytoin therapy. Neurology, 27, 818–820.Google Scholar
Hopf, H.C. (1968). Effect of diphenylhydantoin on peripheral nerves in man. Electroencephalography and Clinical Neurophysiology, 25, 411.Google ScholarPubMed
Horwitz, S., Klipstein, F. and Lovelace, R. (1968). Relation of abnormal folate metabolism to neuropathy developing during anticonvulsant drug therapy. Lancet, 1, 563–565.CrossRefGoogle ScholarPubMed
Kutt, H. and Solomon, G.E. (1980). Phenytoin: relevant side-effects. In: Antiepileptic Drugs: Mechanisms of Action, eds Glaser, G.H.Penry, J.K. and Woodbury, D.M.. Raven Press, New York, pp. 435–445.Google Scholar
Laxer, K.D., Robertson, L.T., Julien, R.M. and Dow, R.S. (1980). Phenytoin: relationship between cerebellar function and epileptic discharges. In: Antiepileptic Drugs: Mechanisms of Action, eds. Glaser, G.H.Penry, J.K. and Woodbury, D.M.Raven Press, New York, pp. 415–426.Google Scholar
Lovelace, R.E. and Horwitz, S.J. (1968). Peripheral neuropathy in long-term dyphenylhydantoin therapy. Arch. Neurol. (Chic), 18, 69–77.Google Scholar
Marcus, D.J., Swift, T.R. and McDonald, T.F. (1981). Acute effects of phenytoin on peripheral nerve function in the rat. Muscle and Nerve, 4: 48–50.CrossRefGoogle ScholarPubMed
Nutrition Canada (1975). The Quebec Survey Report. A report from the Nutrition Canada by the Bureau of Nutritional Sciences. Ottawa, Department of National Health and Welfare, pp. 119–120.Google Scholar
Plaitakis, A., Nicklas, W.J., Berl, S. (1978). Thiamine deficiency: selective impairment of the cerebellar serotonergic system. Neurology, 28, 691–698.CrossRefGoogle ScholarPubMed
Reynolds, E.H., Preece, J. and Johnson, A.L. (1971). Folate metabolism in epileptic and psychiatric patients. J. Neurol. Neurosurg. Psychiatry, 34, 726–732.CrossRefGoogle ScholarPubMed
Shorvon, S.D. (1979). Anticonvulsant therapy and peripheral neuropathy. In: Folic Acid in Neurology, Psychiatry and Internal Medicine, eds. Botez, M.I. and Reynolds, E.H.. Raven Press, New York, pp. 335–348.Google Scholar
Singer, H.S., Butler, I., Rothenberg, S., Valle, D. and Freeman, J. (1980). Interrelationships among serum folate, CSF folate, neurotransmitters and neuropsychiatric symptoms. Neurology, 30, 419.Google Scholar
Young, S.N., Gauthier, S., Anderson, G.M. and Purdy, W.C. (1980). Tryptophan, 5-hydroxyindoleacetic acid and indoleacetic acid in human cerebrospinal fluid: interrelationships and the influence of age, sex, epilepsy and anticonvulsant drugs. J. Neurol. Neurosurg. Psychiatry, 143, 438–445.CrossRefGoogle Scholar
Wells, D.G. and Casey, H.J. (1967). Lactobacillus casei CSF folate activity. Br. Med. J., 3, 834–835.Google ScholarPubMed