Hostname: page-component-745bb68f8f-cphqk Total loading time: 0 Render date: 2025-01-21T23:37:13.504Z Has data issue: false hasContentIssue false
  • English
  • Français

Astrocytoma Following Scalp Radiotherapy in Infancy

Published online by Cambridge University Press:  18 September 2015

Douglas W. Zochodne ,
J. Gregory Cairncross ,
Felix P. Arce ,
John C.F. MacDonald ,
Warren T. Blume ,
John P. Girvin  and
John C.E. Kaufmann
Douglas W. Zochodne
Affiliation:
the Departments of Clinical Neurological Sciences, Pathology (Neuropathology) and Radiation Oncology, University of Western Ontario, London, Canada, and Ontario Cancer Treatment and Research Foundation
J. Gregory Cairncross*
Affiliation:
the Departments of Clinical Neurological Sciences, Pathology (Neuropathology) and Radiation Oncology, University of Western Ontario, London, Canada, and Ontario Cancer Treatment and Research Foundation
Felix P. Arce
Affiliation:
the Departments of Clinical Neurological Sciences, Pathology (Neuropathology) and Radiation Oncology, University of Western Ontario, London, Canada, and Ontario Cancer Treatment and Research Foundation
John C.F. MacDonald
Affiliation:
the Departments of Clinical Neurological Sciences, Pathology (Neuropathology) and Radiation Oncology, University of Western Ontario, London, Canada, and Ontario Cancer Treatment and Research Foundation
Warren T. Blume
Affiliation:
the Departments of Clinical Neurological Sciences, Pathology (Neuropathology) and Radiation Oncology, University of Western Ontario, London, Canada, and Ontario Cancer Treatment and Research Foundation
John P. Girvin
Affiliation:
the Departments of Clinical Neurological Sciences, Pathology (Neuropathology) and Radiation Oncology, University of Western Ontario, London, Canada, and Ontario Cancer Treatment and Research Foundation
John C.E. Kaufmann
Affiliation:
the Departments of Clinical Neurological Sciences, Pathology (Neuropathology) and Radiation Oncology, University of Western Ontario, London, Canada, and Ontario Cancer Treatment and Research Foundation
*
391 South Street, London, Ontario, Canada N6A 4G5
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

A 24 year old woman with a 15 year history of intractable seizures underwent resection of a small low grade astrocytoma of the right mesial frontal lobe. The tumor arose beneath a benign scalp nevus that had been treated in infancy with radium patches and focal x-irradiation. Neuropathological changes within the tumor were compatible with radiation injury. Meningiomas and sarcomas complicate cranial irradiation but the evidence that gliomas do so is less convincing. Our observations support an association between radiation exposure and the subsequent development of glial tumors.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 11 , Issue 4 , November 1984 , pp. 475 - 478
Copyright
Copyright © Canadian Neurological Sciences Federation 1984

References

Albert, RE., Omran, AR., Brauer, EW., et al (1966) Follow-up study of patients treated by x-ray for tinea capitis. Am J Public Health 56: 2114–2120.CrossRefGoogle ScholarPubMed
Bachman, DS., Ostrow, FT. (1978) Fatal long-term sequela following radiation “cure” for ependymoma. Ann Neurol 4: 319–321.CrossRefGoogle ScholarPubMed
Barnes, AE., Liwnicz, BH., Schellhas, HF., Altshuler, G., Aron, BS., Lippert, WA. (1982) Successful treatment of placental choriocarcinoma metastatic to brain followed by primary brain glioblastoma. Gynecol Oncol 13: 108–114.CrossRefGoogle ScholarPubMed
Beller, AJ., Feinsod, M., Sahar, A. (1972) The possible relationship between small dose irradiation to the scalp and intracranial meningomas. Neurochirurgia 4: 135–143.Google Scholar
Chung, CK., Stryker, JA., Cruse, R., Vannuci, R., Towflight, J. (1981) Glioblastoma multiforme following prophylactic cranial irradiation and intrathecal methotrexate in a child with acute lymphocytic leukemia. Cancer 47: 2563–2566.3.0.CO;2-O>CrossRefGoogle Scholar
Clifton, MD., Amromin, GD., Perry, MC., Abadir, R., Watts, C., Levy, N. (1980) Spinal cord glioma following irradiation for Hodgkin’s disease. Cancer 45: 2051–2055.3.0.CO;2-3>CrossRefGoogle ScholarPubMed
Cohen, MS., Kushner, MJ., Dell, S. (1981) Frontal lobe astrocytoma following radiotherapy for medulloblastoma. Neurol (NY) 31: 616–619.CrossRefGoogle ScholarPubMed
Haymaker, W., Rubinstein, LJ., Miquel, J. (1972) Brain tumors in irradiated monkeys. Acta Neuropath 20: 267–277.CrossRefGoogle ScholarPubMed
Jones, A. (1960) Supervoltage x-ray therapy for intracranial tumors. Ann R Coll Surg Engl 27: 310–354.Google Scholar
Kleriga, E., Sher, JH., Nallainathan, S., Stein, SC., Sacher, M. (1978) Development of cerebellar malignant astrocytoma at site of medulloblastoma treated 11 years earlier. J Neurosurg 49: 445–449.CrossRefGoogle ScholarPubMed
Komaki, S., Komaki, R., Choi, H., Correa-Paz, F. (1977) Radiation and drug induced intracranial neoplasm with angiographic demonstration. Neurol Med Chir (Tokyo) 17: 55–62.CrossRefGoogle ScholarPubMed
Modan, B., Baidatz, D., Mart, H., Steinitz, R., Levin, SG. (1974) Radiation-induced head and neck tumors. Lancet 1: 277–279.CrossRefGoogle Scholar
Munk, J., Peyser, E., Gruszkiewicz, J. (1969) Radiation-induced intracranial meningiomas. Clin Radiol 20: 90–94.CrossRefGoogle ScholarPubMed
Pearl, GS., Mirra, SS., Miles, ML. (1980) Glioblastoma multiforme occurring 13 years after treatment of a medulloblastoma. Neurosurgery 6: 546–551.CrossRefGoogle ScholarPubMed
Piatt, JH., Blue, JM., Schold, SC., Burger, PC. (1983) Glioblastoma multiforme after radiotherapy for acromegaly. Neurosurgery 13: 85–89.CrossRefGoogle ScholarPubMed
Preissig, SH., Bohmfalk, GL., Reichel, GW.Smith, MT. (1979) Anaplastic astrocytoma following radiation for a glomus jugulare tumor. Cancer 43: 2243–2247.3.0.CO;2-K>CrossRefGoogle Scholar
Robinson, RG. (1978) A second brain tumor and irradiation. J Neurol Neurosurg Psychiat 41: 1005–1012.CrossRefGoogle ScholarPubMed
Rottenberg, DA., Chernik, NL., Deck, MDF., Ellis, F., Posner, JB. (1977) Cerebral necrosis following radiotherapy of extracranial neoplasms. Ann Neurol 1: 339–357.CrossRefGoogle ScholarPubMed
Saenger, EL., Silverman, FN., Sterling, TD., Turner, ME. (1960) Neoplasia following therapeutic irradiation for benign conditions in childhood. Radiology 74: 889–904.CrossRefGoogle ScholarPubMed
Sogg, RL., Donaldson, SS., Yorke, CH. (1978) Malignant astrocytoma following radiotherapy of a craniopharyngioma. J Neurosurg 48: 622–627.CrossRefGoogle Scholar
Spallone, A., Gagliardi, FM., Vagnozzi, R. (1979) Intracranial meningiomas related to external cranial irradiation. Surg Neurol 12: 153–159.Google ScholarPubMed
Steinbok, P. (1980) Spinal cord glioma after multiple fluoroscopies during artificial pneumothorax treatment of pulmonary tuberculosis. J Neurosurg 52: 838–841.CrossRefGoogle ScholarPubMed