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Wheat-fibre-induced changes of postprandial peptide YY and ghrelin responses are not associated with acute alterations of satiety

Published online by Cambridge University Press:  08 March 2007

Martin O. Weickert ,
Joachim Spranger ,
Jens J. Holst ,
Bärbel Otto ,
Corinna Koebnick ,
Matthias Möhlig  and
Andreas F. H. Pfeiffer
Martin O. Weickert*
Affiliation:
Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 155, 14558 Nuthetal, Germany Department of Endocrinology, Diabetes and Nutrition, Charité-University-Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
Joachim Spranger
Affiliation:
Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 155, 14558 Nuthetal, Germany Department of Endocrinology, Diabetes and Nutrition, Charité-University-Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
Jens J. Holst
Affiliation:
Department of Medical Physiology, The Panum Institute, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark
Bärbel Otto
Affiliation:
Department of Medicine, University Hospital Innenstadt, Ziemssenstrasse 1, 80336 Munich, Germany
Corinna Koebnick
Affiliation:
Department of Preventive Medicine, University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90033, USA
Matthias Möhlig
Affiliation:
Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 155, 14558 Nuthetal, Germany Department of Endocrinology, Diabetes and Nutrition, Charité-University-Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
Andreas F. H. Pfeiffer
Affiliation:
Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 155, 14558 Nuthetal, Germany Department of Endocrinology, Diabetes and Nutrition, Charité-University-Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
*
*Corresponding author: Dr Martin O. Weickert, fax +49 33200 88 777, email [email protected]
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Abstract

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Weight gain and risk of type 2 diabetes are inversely associated with a high intake of insoluble cereal fibres. Because nutrient-induced changes of ‘satiety hormones’ from the gut may play a role in this process, we evaluated the effects of purified insoluble fibres on postprandial responses of plasma peptide YY (PYY), serum ghrelin and satiety as secondary outcome measures of a study investigating effects of cereal fibres on parameters of glucose metabolism. Fourteen healthy women were studied on six occasions in a randomized, single-blind, controlled crossover design. After 24 h run-in periods and 10 h overnight fasts, subjects ingested isoenergetic and macronutrient matched portions of control white bread or fibre-enriched bread (wheat-fibre or oat-fibre) at 08.15 hours. Gut hormones and hunger scores were measured for 300 min. Basal PYY and ghrelin concentrations were not different between the test meals (P>0·15). Postprandial responses of PYY and ghrelin were blunted after the intake of wheat-fibre (total area under the curve (AUC) PYY, 177·9 (sem 8·1) (pmol/l) min; P=0·016; ghrelin 51·0 (sem 2·5) (pmol/l) min; P=0·003), but not after oat-fibre (PYY 226·7 (sem 25·7) (pmol/l) min; P>0·15; ghrelin 46·2 (sem 1·6) (pmol/l) min; P=0·127), compared to control (PYY 247·5 (sem 25·6) (pmol/l) min; ghrelin 42·5 (sem 1·3) (pmol/l) min). Postprandial hunger scores were unaffected by the different test meals (P>0·15). Thus, oat- and wheat-fibre consumption result in different postprandial responses of PYY and ghrelin, but interestingly do not differ in satiety effects.

Keywords

Insoluble cereal fibreSatietyPeptide YYGhrelin
Type
Short Communication
Information
British Journal of Nutrition , Volume 96 , Issue 5 , November 2006 , pp. 795 - 798
Copyright
Copyright © The Nutrition Society 2006

References

Adrian, TE, Ferri, GL, Bacarese-Hamilton, AJ, Fuessl, HS, Polak, JM & Bloom, SR (1985) Human distribution and release of a putative new gut hormone, peptide YY. Gastroenterology 89, 1070–1077.CrossRefGoogle ScholarPubMed
Akamizu, T, Takaya, K & Irako, T (2004) Pharmacokinetics, safety, and endocrine and appetite effects of ghrelin administration in young healthy subjects. Eur J Endocrinol 150, 447–455.CrossRefGoogle ScholarPubMed
Arosio, M, Ronchi, CL, Beck-Peccoz, P, Gebbia, C, Giavoli, C, Cappiello, V, Conte, D & Peracchi, M (2004) Effects of modified sham feeding on ghrelin levels in healthy human subjects. J Clin Endocrinol Metab 89, 5101–5104.CrossRefGoogle ScholarPubMed
Batterham, RL, Cohen, MA, Ellis, SM, Le Roux, CW, Withers, DJ, Frost, GS, Ghatei, MA & Bloom, SR (2003) Inhibition of food intake in obese subjects by peptide YY3-36. N Engl J Med 349, 941–948.CrossRefGoogle ScholarPubMed
Caixas, A, Bashore, C, Nash, W, Pi-Sunyer, F & Laferrere, B (2002) Insulin, unlike food intake, does not suppress ghrelin in human subjects. J Clin Endocrinol Metab 87, 1902.CrossRefGoogle Scholar
Cummings, DE, Frayo, RS, Marmonier, C, Aubert, R & Chapelot, D (2004) Plasma ghrelin levels and hunger scores in humans initiating meals voluntarily without time- and food-related cues. Am J Physiol Endocrinol Metab 287, E297–E304.CrossRefGoogle ScholarPubMed
Erdmann, J, Topsch, R, Lippl, F, Gussmann, P & Schusdziarra, V (2004) Postprandial response of plasma ghrelin levels to various test meals in relation to food intake, plasma insulin, and glucose. J Clin Endocrinol Metab 89, 3048–3054.CrossRefGoogle ScholarPubMed
Flanagan, DE, Evans, ML, Monsod, TP, Rife, F, Heptulla, RA, Tamborlane, WV & Sherwin, RS (2003) The influence of insulin on circulating ghrelin. Am J Physiol Endocrinol Metab 284, E313–E316.CrossRefGoogle ScholarPubMed
Halatchev, IG & Cone, RD (2005) Peripheral administration of PYY(3–36) produces conditioned taste aversion in mice. Cell Metab 1, 159–168.CrossRefGoogle ScholarPubMed
Holt, SH, Miller, JC, Petocz, P & Farmakalidis, E (1995) A satiety index of common foods. Eur J Clin Nutr 49, 675–690.Google ScholarPubMed
Jenkins, DJ, Kendall, CW, Axelsen, M, Augustin, LS & Vuksan, V (2000) Viscous and nonviscous fibres, nonabsorbable and low glycaemic index carbohydrates, blood lipids and coronary heart disease. Curr Opin Lipidol 11, 49–56.CrossRefGoogle ScholarPubMed
Mohlig, M, Spranger, J, Otto, B, Ristow, M, Tschop, M & Pfeiffer, AF (2002) Euglycemic hyperinsulinemia, but not lipid infusion, decreases circulating ghrelin levels in humans. J Endocrinol Invest 25, RC36–RC38.CrossRefGoogle Scholar
Naslund, E, Bogefors, J, Skogar, S, Gryback, P, Jacobsson, H, Holst, JJ & Hellstrom, PM (1999) GLP-1 slows solid gastric emptying and inhibits insulin, glucagon, and PYY release in humans. Am J Physiol 277, R910–R916.Google ScholarPubMed
Overduin, J, Frayo, RS, Grill, HJ, Kaplan, JM & Cummings, DE (2005) Role of the duodenum and macronutrient type in ghrelin regulation. Endocrinology 146, 845–850.CrossRefGoogle ScholarPubMed
Pedersen-Bjergaard, U, Host, U, Kelbaek, H, Schifter, S, Rehfeld, JF, Faber, J & Christensen, NJ (1996) Influence of meal composition on postprandial peripheral plasma concentrations of vasoactive peptides in man. Scand J Clin Lab Invest 56, 497–503.CrossRefGoogle ScholarPubMed
Schaller, G, Schmidt, A, Pleiner, J, Woloszczuk, W, Wolzt, M & Luger, A (2003) Plasma ghrelin concentrations are not regulated by glucose or insulin: a double-blind, placebo-controlled crossover clamp study. Diabetes 52, 16–20.CrossRefGoogle ScholarPubMed
Shiiya, T, Nakazato, M, Mizuta, M, Date, Y, Mondal, MS, Tanaka, M, Nozoe, S, Hosoda, H, Kangawa, K & Matsukura, S (2002) Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. J Clin Endocrinol Metab 87, 240–244.CrossRefGoogle ScholarPubMed
Small, CJ & Bloom, SR (2004) Gut hormones and the control of appetite. Trends Endocrinol Metab 15, 259–263.CrossRefGoogle ScholarPubMed
Weickert, MO, Mohlig, M & Koebnick, C (2005) Impact of cereal fibre on glucose-regulating factors. Diabetologia 48, 2343–2353.CrossRefGoogle ScholarPubMed