Hostname: page-component-78c5997874-94fs2 Total loading time: 0 Render date: 2024-11-14T13:22:31.022Z Has data issue: false hasContentIssue false
  • English
  • Français

Selenium and vitamin E status of healthy and institutionalized elderly subjects: analysis of plasma, erythrocytes and platelets

Published online by Cambridge University Press:  09 March 2007

Douglas Campbell ,
Valda W. Bunker ,
Anita J. Thomas  and
Barbara E. Clayton
Douglas Campbell
Affiliation:
Chemical Pathology and Human Metabolism, University of Southampton, Southampton General Hospital, Tremona Road, Southampton S09 4XY
Valda W. Bunker
Affiliation:
University Geriatric Medicine, University of Southampton, Southampton General Hospital, Tremona Road, Southampton S09 4XY
Anita J. Thomas
Affiliation:
University Geriatric Medicine, University of Southampton, Southampton General Hospital, Tremona Road, Southampton S09 4XY
Barbara E. Clayton
Affiliation:
Faculty of Medicine, University of Southampton, Southampton General Hospital, Tremona Road, Southampton S09 4XY
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Levels of selenium in whole blood, plasma, erythrocytes and platelets, glutathione peroxidase (EC 1.11.1.9; GSH-Px) activity in erythrocytes and platelets and vitamin E, low-density-lipoprotein (LDL)-cholesterol and vitamin E: LDL cholesterol in plasma were measured in seventy-five healthy subjects aged < 65 years and twenty-eight healthy and twenty-three institutionalized elderly people aged > 65 years. Healthy elderly subjects had significantly lower levels of Se in whole blood and plasma when compared with younger subjects. Other measurements of Se status were not significantly different. In the healthy subjects plasma levels of vitamin E and LDL-cholesterol increased with age to 60 years and decreased above 80 years. Vitamin E: LDL cholesterol values were not affected by age. Measurements of Se and vitamin E status in the institutionalized elderly compared with the healthy elderly were all reduced with the exception of platelet Se levels and erythrocyte GSH-Px activity. Ageing per se had minimal effect on Se and vitamin E status but intercurrent illness and decreased food intake can lead to reduced levels in the elderly.

Keywords

SeleniumVitamin EOld age
Type
Research Article
Information
British Journal of Nutrition , Volume 62 , Issue 1 , July 1989 , pp. 221 - 227
Copyright
Copyright © The Nutrition Society 1989

References

REFERENCES

Beutler, E. (1979). Glutathione peroxidase (GSH-Px). In A Manual of Biochemical Methods, 2nd ed, pp. 71–73. New York: Grune and Stratton.Google Scholar
Bieri, J.G., Tolliver, T.J. & Catignani, G.L. (1979). Simultaneous determination of α-tocopherol and retinol in plasma or red cells by high pressure liquid chromatography. American Journal of Clinical Nutrition 32, 2143–2149.CrossRefGoogle ScholarPubMed
Bingham, S., McNeil, N.I. & Cummings, J.H. (1981). The diet of individuals: a study of a randomly-chosen cross section of British adults in a Cambridgeshire village. British Journal of Nutrition 45, 23–25.CrossRefGoogle Scholar
Bunker, V.W., Lawson, M.S., Stansfield, M.F. & Clayton, B.E. (1988). Selenium balance studies in apparently healthy and housebound elderly people eating self-selected diets. British Journal of Nutrition 59, 171–180.CrossRefGoogle ScholarPubMed
Burch, R.E., Sullivan, J.F., Jetton, M.M. & Hahn, H.K.J. (1979). The effect of aging on trace element content of various rat tissues. 1. Early stages of aging. Age 2, 103–107.CrossRefGoogle Scholar
Burk, R.F. (1976). Selenium in man. In Trace Elements in Human Health and Disease, pp. 105–133 [Prasad, A.S. and Oberleas, D., editors]. New York: Academic Press.Google Scholar
Dacie, J.V. & Lewis, S.M. (1984). Practical Haematology, 6th ed. Edinburgh: Churchill Livingstone.Google Scholar
Halliwell, B. & Gutteridge, J.M. (1985). Free Radicals in Biology and Medicine, Oxford: Clarendon Press.Google Scholar
Harman, D. (1981). The aging process. Proceedings of the National Academy of Sciences, USA 78, 7124–7128.CrossRefGoogle ScholarPubMed
Kasperek, K., Lombeck, I., Kiem, J., Iyengar, G.V., Wang, Y.X., Feinendegen, L.E. & Bremer, H.J. (1982). Platelet selenium in children with normal and low selenium intake. Biological Trace Element Research 4, 29–34.CrossRefGoogle ScholarPubMed
Kelleher, J. & Losowsky, M.S. (1978). Vitamin E in the elderly. In Tocopherol, Oxygen and Biomembranes, pp. 311–327 [de Duve, C. and Hayaishi, O., editors]. Amsterdam: Elsevier/North Holland Biomedical Press.Google Scholar
Levander, O.A., DeLoach, D.P., Morris, V.C. & Moser, P.B. (1983). Platelet glutathione peroxidase activity as an index of selenium status in rats. Journal of Nutrition 113, 55–63.CrossRefGoogle ScholarPubMed
Lewis, B., Chait, A., Wootton,, I.D.P., Oakley, C.M., Krinkler, D.M., Sigurdsson, G., February, A., Maurer, B. & Birkhead, J. (1974). Frequency of risk factors for ischaemic heart-disease in a healthy British population. With particular reference to serum-lipoprotein levels. Lancet i, 141–146.CrossRefGoogle Scholar
Lewis, J.S., Pian, A.K., Baer, M.T., Acosta, P.B. & Emerson, G.A. (1973). Effect of long-term ingestion of polyunsaturated fat, age, plasma cholesterol, diabetes mellitus, and supplemental tocopheral upon plasma tocopherol. American Journal of Clinical Nutrition 26, 136–143.CrossRefGoogle Scholar
Lloyd, B., Holt, P. & Delves, H.T. (1982). Determination of selenium in biological samples by hydride-generation and atomic absorption spectroscopy. Analyst 107, 927–933.CrossRefGoogle ScholarPubMed
Lloyd, B., Lloyd, R.S. & Clayton, B. (1983). Effect of smoking, alcohol, and other factors on the selenium status of a healthy population. Journal of Epidemiology and Community Health 37, 213–217.CrossRefGoogle ScholarPubMed
Lowry, O.H., Rosebrough, N.J., Farr, A.L. & Randall, R.J. (1951). Protein measurement with folin phenol reagent. Journal of Biological Chemistry 193, 265–275.CrossRefGoogle ScholarPubMed
McCormick, E.C., Cornwell, D.G. & Brown, J.B. (1960). Studies on the distribution of tocopherol in human serum lipoproteins. Journal of Lipid Research 1, 221–228.CrossRefGoogle Scholar
Menzel, H., Steiner, G., Lombeck, I. & Ohnesorge, F.K. (1983). Glutathione peroxidase and glutathione S-transferase activity of platelets. European Journal of Paediatrics 140, 244–247.CrossRefGoogle ScholarPubMed
Miller, L., Mills, B.J., Blotcky, A.J. & Lindeman, R.D. (1983). Red blood cell and serum selenium concentrations as influenced by age and selected diseases. Journal of the American College of Nutrition 4, 331–334.CrossRefGoogle Scholar
Neve, J., Vertongen, F. & Molle, L. (1985). Selenium deficiency. Clinics in Endocrinology and Metabolism 14, 629–656.CrossRefGoogle ScholarPubMed
Persigehl, M., Schicha, H., Kasperek, K. & Klein, H.J. (1977). Trace element concentrations in human organs in dependence of age. Beiträge zur Patholozie 161, 209–220.CrossRefGoogle ScholarPubMed
Shaper, A.G., Pocock, S.J., Walker, M., Wale, C.J., Clayton, B., Delves, H.T. & Hinks, L. (1982). Effects of alcohol and smoking on blood lead in middle-aged British men. British Medical Journal 284, 299–302.CrossRefGoogle ScholarPubMed
Sullivan, J.F., Blotcky, A.J., Jetton, M.M., Hahn, H.K.J. & Burch, R.E. (1979). Serum levels of selenium, calcium, copper, magnesium, manganese and zinc in various human diseases. Journal of Nutrition 109, 1432–1437.CrossRefGoogle ScholarPubMed
Thomas, A.J., Bunker, V.W., Hinks, L.J., Sodha, N., Mullee, M.A. & Clayton, B.E. (1988). Energy, protein, zinc and copper status of twenty-one elderly inpatients: analysed dietary intake and biochemical indices. British Journal of Nutrition 59, 181–191.CrossRefGoogle ScholarPubMed
Thomson, C.D., Rea, H.M., Robinson, M.F. & Chapman, O.W. (1977). Low blood selenium concentrations and glutathione peroxidase activities in the elderly. Proceedings of the University of Otago Medical School 55, 18–19.Google Scholar
Vandewoude, M.F.J. & Vandewoude, M.G. (1987). Vitamin E status in a normal population: the influence of age. Journal of the American College of Nutrition 6, 307–311.CrossRefGoogle Scholar
van Rij, A.M., Wade, C., Kirk, I., Thomson, C. & Robinson, M.F. (1987). Altered platelet lipoxygenase activity in patients with low selenium. Clinical Science 73, 525–529.CrossRefGoogle ScholarPubMed
Vatassery, G.T., Johnson, G.J. & Krezowski, A.M. (1983). Changes in vitamin E concentrations in human plasma and platelets with age. Journal of the American College of Nutrition 4, 369–375.CrossRefGoogle Scholar
Verlinden, M., van Sprundel, M., Van der Auwera, J.C. & Eylenbosch, W.J. (1983a). The selenium status of Belgian population groups. II. Newborns, children and the aged. Biological Trace Element Research 5, 103–113.CrossRefGoogle ScholarPubMed
Verlinden, M., van Sprundel, M., Van der Auwera, J.C. & Eylenbosch, W.J. (1983b). The selenium status of Belgian population groups. I. Healthy adults. Biological Trace Element Research 5, 91–102.CrossRefGoogle ScholarPubMed
Wako Chemicals GmbH. β-Lipoprotein C Method Sheet. Neuss, West Germany: Wako Chemicals GmbH.Google Scholar
Wei Wo, C.K. & Draper, H.H. (1975). Vitamin E status of Alaskan Eskimos. American Journal of Clinical Nutrition 28, 808–813.CrossRefGoogle ScholarPubMed