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Selenium absorption and retention from a selenite- or selenate-fortified milk-based formula in men measured by a stable-isotope technique

Published online by Cambridge University Press:  09 March 2007

Peter Van Dael ,
Lena Davidsson ,
Rafael Muñoz-Box ,
Laurent B. Fay  and
Denis Barclay
Rafael Muñoz-Box
Affiliation:
Nestlé Research Centre, PO Box 44, Vers-chez-les-Blanc, CH-1000 Lausanne, Switzerland
Laurent B. Fay
Affiliation:
Nestlé Research Centre, PO Box 44, Vers-chez-les-Blanc, CH-1000 Lausanne, Switzerland
Denis Barclay
Affiliation:
Nestlé Research Centre, PO Box 44, Vers-chez-les-Blanc, CH-1000 Lausanne, Switzerland
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Abstract

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The present study was designed to determine the apparent absorption and retention of the inorganic Se compounds SeO32- and SeO42-, which are commonly used for Se fortification of clinical nutrition products and infant formulas. Ten healthy men were fed a milk-based formula labelled with 40 μg Se as 74SeO32- or 76SeO42- on two consecutive days using a randomised crossover design. Se stable-isotope analysis of 9 d complete collections of urine and faeces was used to calculate apparent Se absorption and retention. Se retention from 74SeO32- (41·0 (SD 8·4) %) AND FROM 76SEO42- (46·0 (sd 7·9) %) was not significantly different (P>0·05). However, Se absorption was significantly higher from SeO42- than from SeO32- (91·3 (sd 1·4) % v. 50·2 (sd 7·8) %, P<0·05). Urinary excretion of the administered dose was 9·2 (sd 1·8) % for 74SeO32- and 45y3 (sd 8·2) % for 76SeO42- (P<0·05). Urinary Se excretion kinetics differed significantly for the two Se compounds; 90 % of the total urinary Se was excreted after 121 h for 74SeO32- and after 40 h for 76SeO42- (P<0·05). These results suggest that although Se absorption and urinary excretion differ for SeO32- and SeO42-, both Se compounds are equally well retained when administered at a relatively low dose (40 μg Se). The nutritional impact of Se fortification of foods would thus be expected to be similar when SeO42- or SeO32- are used.

Keywords

Selenium fortificationSelenium absorptionSelenium retentionInorganic selenium compoundsStable isotopes
Type
Research Article
Information
British Journal of Nutrition , Volume 85 , Issue 2 , February 2001 , pp. 157 - 163
Copyright
Copyright © The Nutrition Society 2001

References

Alfthan, G, Aro, A, Arvilommi, H & Huttunen, JK (1991) Selenium metabolism and platelet glutathione peroxidase activity in healthy Finnish men: effects of selenium yeast, selenite, and selenate. American Journal of Clinical Nutrition 53, 120–125.Google Scholar
Beck, MA (1996) The role of nutrition in viral disease. Journal of Nutritional Biochemistry 7, 683–690.CrossRefGoogle Scholar
Belsten, JL & Wright, AJA (1995) European Community – FLAIR common assay for whole-blood glutathione peroxidase (GSH-Px). Results of an interlaboratory trial. European Journal of Clinical Nutrition 49, 921–927.Google Scholar
Casey, CE, Hambidge, KM (1985) Trace minerals Vitamin and Mineral. In Vitamin and Mineral Requirements in Preterm Infants, 153–184.[Tsang, RC, editors]. New York: Marcel Dekker.Google Scholar
Chandra, RK (1997) Nutrition and the immune system: an introduction. American Journal of Clinical Nutrition 66, 460S-463S.Google Scholar
Christensen, MJ, Janghorbani, M, Steinke, FH, Istfan, N & Young, VR (1983) Simultaneous determination of absorption of selenium from poultry meat and selenite in young men: application of a triple stable-isotope method. British Journal of Nutrition 50, 43–50.CrossRefGoogle ScholarPubMed
Clark, LC, Combs, GF & Turnbull, BW (1996) Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. Journal of the American Medical Association 276, 1957–1963.Google Scholar
Ducros, V, Favier, A & Guigues, M (1991) Selenium bioavailability as selenite (74Se) and as a selenium drug (76Se) by stable isotope methodology. Journal of Trace Elements and Electrolytes in Health and Disease 5, 145–154.Google ScholarPubMed
Finley, JW (1999) The retention and distribution by healthy young men of stable isotopes of selenium consumed as selenite, selenate or hydroponically-grown broccoli are dependent on the isotopic form. Journal of Nutrition 129, 865–871.Google Scholar
Hambidge, KM, WA, Walker & JB, Watkins (1985) Trace elements in human In nutrition Nutrition in Pediatrics. Basic Science and Clinical Applications 7–45.[WA, Walker & JB, Watkins, editors]. Boston, MA: Little Brown Co.Google Scholar
Hills, M & Armitage, P (1979) The two-period cross-over clinical trial. British Journal of Clinical Pharmacology 8, 7–20.CrossRefGoogle ScholarPubMed
Janghorbani, M, Christensen, MJ, Nahapetian, A & Young, VR (1982) Selenium metabolism in healthy adults: quantitative aspects using the stable isotope 74SeO32-. American Journal of Clinical Nutrition 35, 647–654.Google Scholar
Kasper, LJ, Young, VR & Janghorbani, M (1984) Short-term dietary selenium restriction in young adults: quantitative studies with the stable isotope 74SeO32-. British Journal of Nutrition 52, 443–455.Google Scholar
Kelly, DA, Coe, AW, Shenkin, A, Lake, BD & Walker-Smith, JA (1988) Symptomatic selenium deficiency in a child on home parenteral nutrition. Journal of Gastroenterology and Nutrition 7, 783–786.Google Scholar
Levander, OA (1984) The importance of selenium in total parenteral nutrition. Bulletin of the New York Academy of Medicine 60, 144–155.Google ScholarPubMed
Litov, R & Combs, G (1991) Selenium in pediatric nutrition. Pediatrics 87, 339–351.Google Scholar
Lockitch, G (1989) Selenium: clinical significance and analytical concepts. CRC Critical Reviews in Clinical Laboratory Sciences 27, 483–539.Google Scholar
Makarem, A, RJ, Henry, DC, Cannon & JW, Winkelman (1974) Trace elements in human nutrition. In Principles and Techniques 1125–1147 [RJ, Henry, DC, Cannon & JW, Winkelman, editors]. Hagerstown,MD: Harper & Row.Google Scholar
Mangels, AR, Moser-Veillon, PB, Patterson, KY & Veillon, C (1990) Selenium utilization during human lactation by use of stable-isotope tracers. American Journal of Clinical Nutrition 52, 621–627.Google Scholar
Martin, RF, Janghorbani, M & Young, VR (1989) Experimental selenium restriction in healthy adult humans: changes in selenium metabolism studied with stable-isotope methodology. American Journal of Clinical Nutrition 49, 854–861.Google Scholar
National Research Council (1989) Recommended Dietary Allowances,10th ed. Washington, DC: National Academy Press.Google Scholar
Nève, J (1995) Human selenium supplementation as assessed by changes in blood selenium concentration and glutathione peroxidase activity. Journal of Trace Elements in Medicine and Biology 9, 65–76.Google Scholar
Oster, A & Prellwitz, W (1990) The renal excretion of selenium. Biological Trace Element Research 24, 119–146.CrossRefGoogle ScholarPubMed
Patterson, BH, Levander, OA, Helzlsouer, K, McAdam, PA, Lewis, SA, Taylor, PR, Veillon, C & Zech, LA (1989) Human selenite metabolism: a kinetic model. American Journal of Physiology 257, R556-R567.Google ScholarPubMed
Pfannhauser, W (1994) Neue Forschungsergebnisse über Selen (New research data on selenium). Ernärhrung 18, 75–76.Google Scholar
Rannem, T, Hylander, E, Ladefoged, K, Staun, M, Tjellesen, L & Jarnum, S (1996) The metabolism of [75Se]selenite in patients with short bowel syndrome. Journal of Parenteral and Enteral Nutrition 20, 412–416.CrossRefGoogle Scholar
Robberecht, HJ & Deelstra, HA (1984) Selenium in human urine. Determination, speciation and concentration levels. Talanta 7, 497–508.Google Scholar
Sandström, B, Fairweather-Tait, S, Hurrell, R & van Dokkum, W (1993) Methods for studying mineral and trace element absorption in humans using stable isotopes. Nutrition Research Reviews 6, 71–95.CrossRefGoogle ScholarPubMed
Sirichakwal, PP, Young, VR & Janghorbani, M (1985) Absorption and retention of selenium from intrinsically labeled egg and selenite as determined by stable isotope studies in humans. American Journal of Clinical Nutrition 41, 264–269.Google Scholar
Smith, AM, Chen, LW & Thomas, MR (1995) Selenate fortification improves selenium status of term infants fed soy formula. American Journal of Clinical Nutrition 61, 44–47.CrossRefGoogle ScholarPubMed
Thomson, CD & Robinson, MF (1986) Urinary and fecal excretions and absorption of a large supplement of selenium: superiority of selenate over selenite. American Journal of Clinical Nutrition 44, 659–663.Google Scholar
Thomson, CD, Robinson, MF, Butler, JA & Whanger, PD (1993) Long-term supplementation with selenate and selenomethionine: selenium and glutathione peroxidase (EC 1.11.1.9) in blood components of New Zealand women. British Journal of Nutrition 69, 577–588.Google Scholar
Turnlund, JR, Keyes, WR & Peiffer, GL (1993) Isotope ratios of molybdenum determined by thermal ionisation mass spectrometry for stable isotope studies of molybdenum metabolism in humans. Analytical Chemistry 65, 1717–1722.Google Scholar
Tyrala, EE, Borschel, MW & Jacobs, JR (1996) Selenate fortification of infant formulas improves the selenium status of preterm infants. American Journal of Clinical Nutrition 64, 860–865.Google Scholar
Van Dael, P, Barclay, D, Longet, K, Metairon, S & Fay, LB (1998) Determination of selenium stable isotopes by gas chromatography-mass spectrometry with negative chemical ionisation. Journal of Chromatography 715B, 314–317.Google Scholar
Van Dael, P & Deelstra, H (1993) Selenium. International Journal of Vitamin and Nutrition Research 63, 312–316.Google Scholar
Van Dael, P, Van Cauwenbergh, R, Deelstra, H & Calomme, M (1995) Determination of selenium in human serum by longitudinal Zeeman correction and flow injection hydride generation atomic absorption spectrometry. Atomic Spectroscopy 16, 251–257.Google Scholar
van Dokkum, W (1995) The intake of selected minerals and trace elements in European countries. Nutrition Research Reviews 8, 271–302.Google Scholar
Vendeland, SC, Butler, JA & Whanger, PD (1992) Intestinal absorption of selenite, selenate, and selenomethionine in the rat. Journal of Nutritional Biochemistry 3, 359–365.Google Scholar
Vinton, NE, Dahlstrom, KA, Strobel, CT & Ament, ME (1987) Macrocytosis and pseudo-albinism: manifestations of selenium deficiency. Journal of Pediatrics 111, 711–777.Google Scholar
Whanger, PD (1998) Metabolism of selenium in humans. Journal of Trace Elements in Experimental Medicine 11, 227–240.3.0.CO;2-T>CrossRefGoogle Scholar
Wolffram, S, Ardüser, F & Scharrer, E (1985) In vivo intestinal absorption of selenate and selenite by rats. Journal of Nutrition 115, 454–459.Google Scholar
Xia, Y, Zhao, X, Zhu, L & Whanger, PD (1992) Metabolism of selenate and selenomethionine by a selenium-deficient population of men in China. Journal of Nutritional Biochemistry 3, 202–210.Google Scholar
Zachara, BA (1993) Mammalian selenoproteins. Journal of Trace Elements in Health and Disease 6, 137–151.Google Scholar