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Sarcopenia is predictive of nosocomial infection in care of the elderly

Published online by Cambridge University Press:  08 March 2007

Gaëlle Cosquéric
Affiliation:
Service de gériatrie, hôpital Rothschild, Assistance Publique – Hôpitaux de Paris, Paris, France
Aline Sebag
Affiliation:
Service de radiologie, hôpital Rothschild, Assistance Publique – Hôpitaux de Paris, Paris, France
Cyril Ducolombier
Affiliation:
Service de gériatrie, hôpital Rothschild, Assistance Publique – Hôpitaux de Paris, Paris, France
Caroline Thomas
Affiliation:
Service de gériatrie, hôpital Saint Antoine, Assistance Publique – Hôpitaux de Paris, Paris, France
François Piette
Affiliation:
Service de gériatrie, hôpital Rothschild, Assistance Publique – Hôpitaux de Paris, Paris, France
Sébastien Weill-Engerer*
Affiliation:
Service de gériatrie, hôpital Rothschild, Assistance Publique – Hôpitaux de Paris, Paris, France
*
*Corresponding author: Dr Sébastien Weill-Engerer, fax +33 1 40 19 33 64, email [email protected]
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Abstract

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Protein–energy malnutrition and nosocomial infection (NI) are frequent in elderly patients, and a causal link between the two has often been suggested. The aim of the present study was to identify the nutritional parameters predictive of NI in elderly patients. We assessed on admission 101 patients (sixty-six women, thirty-five men, aged over 65 years) admitted to an acute care of the elderly department. Sarcopenia was detected by dual-energy X-ray absorptiometry, with appendicular skeletal muscle mass expressed with respect to body area. Weight, BMI, albuminaemia, serum transthyretin and C-reactive protein values were also determined on admission, and known risk factors, such as functional dependence and invasive biomedical material, were also evaluated. After up to 3 weeks of hospitalisation, patients were classified according to whether they had developed an NI. After 3 weeks of hospitalisation, we found that twenty-nine patients had suffered an NI, occurring after a mean of 16·1 d. Patients who were sarcopenic on admission had a significantly higher risk of contracting an NI (relative risk 2·1, 95 % CI 1·1, 3·8). None of the other morphometric or biological parameters differed significantly between the two groups of patients on admission. Patients who experienced an NI were also more likely, on admission, to have a medical device (P=0·02 to P=0·001 depending on the device), to have swallowing problems (P=0·002) or to have restricted autonomy (P<0·01). Sarcopenia on admission to an acute care of the elderly unit, as measured by X-ray absorptiometry, was therefore associated with a doubled risk of NI during the first 3 weeks of hospitalisation.

Type
Research Article
Copyright
Copyright © The Nutrition Society 2006

References

Baumgartner, RN, Koehler, KM, Gallagher, D, Romero, L, Heymsfield, SB & Ross, RRGarry, PJLindeman, RD (1998) Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol 147, 755763. (Erratum in Am J Epidemiol 1999; 149: 1161).CrossRefGoogle ScholarPubMed
Baumgartner, RN, Stauber, PM, McHugh, D, Koehler, KM & Garry, PJ (1995) Cross-sectional age differences in body composition in persons 60+ years of age. J Gerontol A Biol Sci Med Sci 50, M307M316.CrossRefGoogle ScholarPubMed
Bedogni, G, Marra, M, Bianchi, L, Malavolti, M, Nicolai, E & De Filippo E Scalfi, L (2003) Comparison of bioelectrical impedance analysis and dual-energy X-ray absorptiometry for the assessment of appendicular body composition in anorexic women. Eur J Clin Nutr 57, 10681072.CrossRefGoogle ScholarPubMed
Bienia, R, Ratcliff, S, Barbour, GL & Kummer, M (1982) Malnutrition in the hospitalized geriatric patient. J Am Geriatr Soc 30, 433436.CrossRefGoogle ScholarPubMed
Campbell, WW, Trappe, TA, Wolfe, RR & Evans, WJ (2001) The recommended dietary allowance for protein may not be adequate for older people to maintain skeletal muscle. J Gerontol A Biol Sci Med Sci 56, M373M380.CrossRefGoogle Scholar
Cassou, B & Rothan-Tondeur, M (2000) Controling Nosocomial Infections in Geriatrics. Paris: Assistance Publique – Hopitaux de Paris/Doin Editeurs.Google Scholar
Cederholm, T, Lindgren, JA & Palmblad, J (2000) Impaired leukotriene C4 generation in granulocytes from protein-energy malnourished chronically ill elderly. J Intern Med 247, 715722.CrossRefGoogle ScholarPubMed
Chandra, RK (1992) Protein–energy malnutrition and immunological responses. J Nutr 122, 597600.CrossRefGoogle ScholarPubMed
Chumlea, WC, Roche, AF & Steinbaugh, ML (1985) Estimating stature from knee height for persons 60 to 90 years of age. J Am Geriatr Soc 33, 116120.CrossRefGoogle ScholarPubMed
Constans, T, Bacq, Y, Brechot, JF, Guilmot, JL, Choutet, P & Lamisse, F (1992) Protein–;energy malnutrition in elderly medical patients. J Am Geriatr Soc 40, 263268.CrossRefGoogle ScholarPubMed
Cunnion, KM, Weber, DJ, Broadhead, WE, Hanson, LC, Pieper, CF & Rutala, WA (1996) Risk factors for nosocomial pneumonia: comparing adult critical-care populations. Am J Respir Crit Care Med 153, 158162.CrossRefGoogle ScholarPubMed
Dormenval, V, Budtz-Jorgensen, E, Mojon, P, Bruyere, A & Rapin, CH (1995) Nutrition, general health status and oral health status in hospitalised elders. Gerodontology 12, 7380.CrossRefGoogle ScholarPubMed
Eckhardt, CL, Adair, LS, Caballero, B, Avila, J, Kon, IY, Wang, J & Popkin, BM (2003) Estimating body fat from anthropometry and isotopic dilution: a four-country comparison. Obes Res 11, 15531562.CrossRefGoogle ScholarPubMed
Edington, J, Boorman, J & Durrant, ER (2000) Prevalence of malnutrition on admission to four hospitals in England. The Malnutrition Prevalence Group. Clin Nutr 19, 191195.CrossRefGoogle ScholarPubMed
Emmerson, AM, Enstone, JE, Griffin, M, Kelsey, MC & Smyth, ET (1996) The Second National Prevalence Survey of infection in hospitals – overview of the results. J Hosp Infect 32, 175190.CrossRefGoogle ScholarPubMed
EPINE Working Group (1992) Prevalence of hospital-acquired infections in Spain. J Hosp Infect 20, 113.CrossRefGoogle Scholar
Erselcan, T, Candan, F, Saruhan, S & Ayca, T (2000) Comparison of body composition analysis methods in clinical routine. Ann Nutr Metab 44, 243248.CrossRefGoogle ScholarPubMed
French Prevalence Survey Study Group (2000) Prevalence of nosocomial infections in France: results of the nationwide survey in 1996. J Hosp Infect 46, 186193.CrossRefGoogle Scholar
Fuller, NJ, Wells, JC & Elia, M (2001) Evaluation of a model for total body protein mass based on dual-energy X-ray absorptiometry: comparison with a reference four-component model. Br J Nutr 86, 4552.CrossRefGoogle Scholar
Garner, JS, Jarvis, WR, Emori, TG, Horan, TC & Hughes, JM (1988) CDC definitions for nosocomial infections, 1988. Am J Infect Control 16, 128140.CrossRefGoogle ScholarPubMed
Gastmeier, P, Kampf, G, Wischnewski, N, Hauer, T, Schulgen, G, Schumacher, M, Daschner, F & Ruden, H (1998) Prevalence of nosocomial infections in representative German hospitals. J Hosp Infect 38, 3749.CrossRefGoogle ScholarPubMed
Gikas, A, Roumbelaki, M & Pediaditis, J (2004) Prevalence of nosocomial infections after surgery in Greek hospitals: results of two nationwide surveys. Infect Control Hosp Epidemiol 25, 319324.CrossRefGoogle ScholarPubMed
Gillette-Guyonnet, S, Nourhashemi, F, Andrieu, S, Cantet, C, Albarede, JL, Vellas, B & Grandjean, H (2003) Body composition in French women 75+ years of age: the EPIDOS study. Mech Ageing Dev 124, 311316.CrossRefGoogle ScholarPubMed
Good, RA & Lorenz, E (1992) Nutrition and cellular immunity. Int J Immunopharmacol 14, 361366.CrossRefGoogle ScholarPubMed
Hanson, LC, Weber, DJ & Rutala, WA (1992) Risk factors for nosocomial pneumonia in the elderly. Am J Med 92, 161166.CrossRefGoogle ScholarPubMed
Harkness, GA, Bentley, DW & Roghmann, KJ (1990) Risk factors for nosocomial pneumonia in the elderly. Am J Med 89, 457463.CrossRefGoogle ScholarPubMed
Houtkooper, LB, Going, SB, Sproul, J, Blew, RM & Lohman, TG (2000) Comparison of methods for assessing body-composition changes over 1 y in postmenopausal women. Am J Clin Nutr 72, 401406.CrossRefGoogle ScholarPubMed
Hussain, M, Oppenheim, BA, O'Neill, P, Trembath, C, Morris, J & Horan, MA (1996) Prospective survey of the incidence, risk factors and outcome of hospital-acquired infections in the elderly. J Hosp Infect 32, 117126.CrossRefGoogle ScholarPubMed
Kampf, G, Gastmeier, P, Wischnewski, N, Schlingmann, J, Schumacher, M, Daschner, F & Ruden, H (1997) Analysis of risk factors for nosocomial infections – results from the first national prevalence survey in Germany (NIDEP Study, Part 1). J Hosp Infect 37, 103112.CrossRefGoogle ScholarPubMed
Katz, S, Ford, AB, Moskowitz, RW, Jackson, BA & Jaffe, MW (1963) Studies of illness in the aged. The index of ADL: a standardized measure of biological and psychosocial function. JAMA 185, 914919.CrossRefGoogle Scholar
Klavs, I & Bufon Luznik, T, Skerl, M et al. (2003) Prevalence of and risk factors for hospital-acquired infections in Slovenia – results of the first national survey, 2001. J Hosp Infect 54, 149157.CrossRefGoogle ScholarPubMed
Klein, S (1990) The myth of serum albumin as a measure of nutritional status. Gastroenterology 99, 18451846.CrossRefGoogle ScholarPubMed
Kyle, UG, Morabia, A, Slosman, DO, Mensi, N, Unger, P & Pichard, C (2001) Contribution of body composition to nutritional assessment at hospital admission in 995 patients: a controlled population study. Br J Nutr 86, 725731.CrossRefGoogle ScholarPubMed
Lemonnier, D, Acher, S, Boukaiba, N, Flament, C, Doucet, C, Piau, A & Chappuis, P (1991) Discrepancy between anthropometry and biochemistry in the assessment of the nutritional status of the elderly. Eur J Clin Nutr 45, 281286.Google ScholarPubMed
Lesourd, B & Mazari, L (1999) Nutrition and immunity in the elderly. Proc Nutr Soc 58, 685695.CrossRefGoogle ScholarPubMed
Lipschitz, DA & Udupa, KB (1986) Influence of aging and protein deficiency on neutrophil function. J Gerontol 41, 690694.CrossRefGoogle ScholarPubMed
Mazari, L & Lesourd, BM (1998) Nutritional influences on immune response in healthy aged persons. Mech Ageing Dev 104, 2540.CrossRefGoogle ScholarPubMed
Mazess, RB, Barden, HS, Bisek, JP & Hanson, J (1990) Dual-energy x-ray absorptiometry for total-body and regional bone-mineral and soft-tissue composition. Am J Clin Nutr 51, 11061112.CrossRefGoogle ScholarPubMed
McWhirter, JP & Pennington, CR (1994) Incidence and recognition of malnutrition in hospital. BMJ 308, 945948.CrossRefGoogle ScholarPubMed
Melton, LJ 3rd, Khosla, S, Crowson, CS, O'Connor, MK, O'Fallon, WM & Riggs, BL (2000) Epidemiology of sarcopenia. J Am Geriatr Soc 48, 625630.Google ScholarPubMed
Michel, JP, Lesourd, B, Conne, P, Richard, D & Rapin, CH (1991) Prevalence of infections and their risk factors in geriatric institutions: a one-day multicentre survey. Bull World Health Organ 69, 3541.Google ScholarPubMed
Mowe, M, Bohmer, T & Kindt, E (1994) Reduced nutritional status in an elderly population (>70 y) is probable before disease and possibly contributes to the development of disease. Am J Clin Nutr 59, 317324.CrossRefGoogle Scholar
Newman, AB, Kupelian, V & Visser, M (2003) Sarcopenia: alternative definitions and associations with lower extremity function. J Am Geriatr Soc 51, 16021609.CrossRefGoogle ScholarPubMed
Omran, ML & Morley, JE (2000) Assessment of protein energy malnutrition in older persons. Part II. Laboratory evaluation. Nutrition 16, 131140.CrossRefGoogle ScholarPubMed
Pinchcofsky, GD & Kaminski, MV Jr (1985) Increasing malnutrition during hospitalization: documentation by a nutritional screening program. J Am Coll Nutr 4, 471479.CrossRefGoogle ScholarPubMed
Pittet, D, Harbarth, S, Ruef, C, Francioli, P, Sudre, P, Petignat, C, Trampuz, A & Widmer, A (1999) Prevalence and risk factors for nosocomial infections in four university hospitals in Switzerland. Infect Control Hosp Epidemiol 20, 3742.CrossRefGoogle ScholarPubMed
Potter, J, Klipstein, K, Reilly, JJ & Roberts, M (1995) The nutritional status and clinical course of acute admissions to a geriatric unit. Age Ageing 24, 131136.CrossRefGoogle ScholarPubMed
Potter, MA & Luxton, G (1999) Prealbumin measurement as a screening tool for protein calorie malnutrition in emergency hospital admissions: a pilot study. Clin Invest Med 22, 4452.Google ScholarPubMed
Reuben, DB, Greendale, GA & Harrison, GG (1995) Nutrition screening in older persons. J Am Geriatr Soc 43, 415425.CrossRefGoogle ScholarPubMed
Rosenthal, AJ, Sanders, KM, McMurtry, CT, Jacobs, MA, Thompson, DD, Gheorghiu, D, Little, KL & Adler, RA (1998) Is malnutrition overdiagnosed in older hospitalized patients? Association between the soluble interleukin-2 receptor and serum markers of malnutrition. J Gerontol A Biol Sci Med Sci 53, M81M86.CrossRefGoogle ScholarPubMed
Rothan-Tondeur, M, Meaume, S, Girard, L, Weill-Engerer, S, Lancien, E, Abdelmalak, S, Rufat, P & Le Blanche, AF (2003) Risk factors for nosocomial pneumonia in a geriatric hospital: a control-case one-center study. J Am Geriatr Soc 51, 9971001.CrossRefGoogle Scholar
Saviteer, SM, Samsa, GP & Rutala, WA (1988) Nosocomial infections in the elderly. Increased risk per hospital day. Am J Med 84, 661666.CrossRefGoogle ScholarPubMed
Scheel, O & Stormark, M (1999) National prevalence survey on hospital infections in Norway. J Hosp Infect 41, 331335.CrossRefGoogle ScholarPubMed
Schneider, SM, Veyres, P, Pivot, X, Soummer, AM, Jambou, P, Filippi, J, van Obberghen, E & Hebuterne, X (2004) Malnutrition is an independent factor associated with nosocomial infections. Br J Nutr 92, 105111.CrossRefGoogle ScholarPubMed
Sullivan, DH, Sun, S & Walls, RC (1999) Protein–energy undernutrition among elderly hospitalized patients: a prospective study. JAMA 281, 20132019.CrossRefGoogle ScholarPubMed
Sun, G, French, CR & Martin, GR (2005) Comparison of multifrequency bioelectrical impedance analysis with dual-energy X-ray absorptiometry for assessment of percentage body fat in a large, healthy population. Am J Clin Nutr 81, 7478.CrossRefGoogle Scholar
Tanko, LB, Movsesyan, L, Mouritzen, U, Christiansen, C & Svendsen, OL (2002) Appendicular lean tissue mass and the prevalence of sarcopenia among healthy women. Metabolism 51, 6974.Google ScholarPubMed
Vaque, J, Rossello, J & Arribas, JL (1999) Prevalence of nosocomial infections in Spain: EPINE study 1990–1997. EPINE Working Group. J Hosp Infect 43, Suppl.S105S111.CrossRefGoogle ScholarPubMed
Wischnewski, N, Kampf, G, Gastmeier, P, Schlingmann, J, Schumacher, M, Daschner, F & Ruden, H (1998) Nosocomial wound infections: a prevalence study and analysis of risk factors. Int Surg 83, 9397.Google ScholarPubMed