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Regulation of hepatic lipogenesis by dietary maize oil or tripalmitin in the meal-fed mouse

Published online by Cambridge University Press:  09 March 2007

G. R. Herzberg  and
N. Janmohamed
G. R. Herzberg
Affiliation:
Department of BiochemistryMemorial University of Newfoundland, St. John's, Newfoundland AI B 3x9, Canada
N. Janmohamed
Affiliation:
Department of BiochemistryMemorial University of Newfoundland, St. John's, Newfoundland AI B 3x9, Canada
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Abstract

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The effect of varying dietary levels of maize oil and tripalmitin (0–250 g fat/kg) on hepatic lipogenesis and the levels of hepatic fatty acid synthetase (FAS), glucose-6-phosphate dehydrogenase (EC 1.1.1.49; G6PD), malic enzyme (EC 1.1.1.38, 1.1.1.39, 1.1.1.40; ME) and glucokinase (EC 2.7.1.2; GK) was examined in meal-fed mice.

2. Meal-fed mice compared to mice fed ad lib. show enhanced hepatic lipogenesis as demonstrated by an increased rate of in vivo fatty acid synthesis and increased levels of FAS, ME and G6PD. The level of GK in meal-fed mice was unchanged by meal feeding.

3. Maize oil more effectively reduced in vivo hepatic lipogenesis than tripalmitin in meal-fed mice.

4. Maize oil more effectively reduced the hepatic levels of FAS, G6PD, ME and GK than tripalmitin in meal-fed mice.

5. The increased inhibition by maize oil is observed at all levels of fat in the diet investigated and has been shown not to be due to decreased carbohydrate intake nor to differences between the absorption of maize oil and tripalmitin.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 43 , Issue 3 , May 1980 , pp. 571 - 579
Copyright
Copyright © The Nutrition Society 1980

References

REFERENCES

Allman, D. & Gibson, D. M. (1965). J. Lipid Res. 6, 51.CrossRefGoogle Scholar
Baker, N. & Huebotter, R. J. (1973). J. Lipid Res. 14, 87.CrossRefGoogle Scholar
Baker, N., Palmquist, D. L. & Learn, D. B. (1976). J. Lipid Res. 17, 527.CrossRefGoogle Scholar
Bartley, J. C. & Abraham, S. (1972). Biochim. biophys. Acta 280, 258.CrossRefGoogle Scholar
Clarke, S. D., Romsos, D. R. & Leveille, G. A. (1976). Lipids 11, 485.CrossRefGoogle Scholar
Clarke, S. D., Romsos, D. R. & Leveille, G. A. (1977 a). J. Nutr. 107, 1170.CrossRefGoogle Scholar
Clarke, S. D., Romsos, D. R. & Leveille, G. A. (1977 b). J. Nutr. 107, 1277.CrossRefGoogle Scholar
Clarke, S. D., Romsos, D. R. & Leveille, G. A. (1977 c). J. Nutr. 107, 1468.CrossRefGoogle Scholar
Cornish, S. & Cawthorne, M. A. (1978). Horm. Metub. Res. 10, 286.CrossRefGoogle Scholar
Dupont, J. (1970). Lipids 5, 908.CrossRefGoogle Scholar
Favarger, P. & Gerlach, J. (1973). C. r. Séanc. Soc. Biol. 1167, 23.Google Scholar
Gibson, D. M. & Hubbard, A. W. (1960). Biochem. blophys. Res. Commun. 3, 351.CrossRefGoogle Scholar
Goa, J. (1953). Scand, J. clin. Lab. Invest. 5, 218.CrossRefGoogle Scholar
Gozukara, E. M., Frolich, M. & Holten, D. (1972). Biochim. biophys. Acta 252, 305.Google Scholar
Hill, R., Linazasoro, J. M.Chevaller, F. & Chaikoff, I. L. (1958). J. biol. Chem. 233, 305.CrossRefGoogle Scholar
Jansen, G. R., Hutchison, C. F. & Zanetti, M. E. (1966). Biochem. J. 99, 323.CrossRefGoogle Scholar
Jansen, G. R., Zanetti, M. E. & Hutchison, C. F. (1968). Biochem. J. 106, 345.CrossRefGoogle Scholar
Lohr, G. W. & Walker, H. O. (1971). In Methods of Enzymatic Analysis, vol. 2, p. 636 [Bergmeyer, H. V., editor]. New York: Academic Press.Google Scholar
Mercer, L. P., Flodin, N. W. & Morgan, P. H. (1978). J. Nutr. 108, 1244.CrossRefGoogle Scholar
Musch, K., Ojakian, M. S. & Williams, M. A. (1974). Biochem. biophys. Acta 337, 343.CrossRefGoogle Scholar
Muto, Y. & Gibson, D. M. (1970), Biochem. biophys. Res. Commnun. 38, 9.CrossRefGoogle Scholar
Pilkis, S. J. (1975). Meths. Enzym. 42, 31.CrossRefGoogle Scholar
Preston, L., Flodin, N. W. & Morgan, P. H. (1978). J. Nutr. 108, 1244.Google Scholar
Sabine, T. R., McGarth, H. & Abraham, S. (1969). J. Nutr. 98, 312.CrossRefGoogle Scholar
Tepperman, H. & Tepperman, J. (1965). Am. J. Physiol. 209, 773.CrossRefGoogle Scholar
Triscari, J., Hamilton, J. G. & Sullivan, A. C. (1978). J. Nutr. 108, 815.CrossRefGoogle Scholar
Waterman, R. A., Romsos, D. R., Tsai, A. C., Miller, E. R. & Leveille, G. A. (1975). Proc. Soc. exp. Biol. Med. 150, 347.CrossRefGoogle Scholar
Wiegand, R. D., Rao, G. A. & Keiser, R. (1973). J. Nutr. 103, 1414.CrossRefGoogle Scholar
Yeh, Y. Y., Leveille, G. A. & Wiley, J. H. (1970). J. Nutr. 100, 917.CrossRefGoogle Scholar