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Postprandial lipoprotein, glucose and insulin responses after two consecutive meals containing rapeseed oil, sunflower oil or palm oil with or without glucose at the first meal

Published online by Cambridge University Press:  09 March 2007

Anette Pedersen ,
Peter Marckmann  and
Brittmarie Sandström
Anette Pedersen*
Affiliation:
Research Department of Human Nutrition, The Royal Veterinary and Agricultural University, Centre for Advanced Food Studies, Rolighedsvej 30, DK-1958 Frederiksberg, Denmark
Peter Marckmann
Affiliation:
Research Department of Human Nutrition, The Royal Veterinary and Agricultural University, Centre for Advanced Food Studies, Rolighedsvej 30, DK-1958 Frederiksberg, Denmark
Brittmarie Sandström
Affiliation:
Research Department of Human Nutrition, The Royal Veterinary and Agricultural University, Centre for Advanced Food Studies, Rolighedsvej 30, DK-1958 Frederiksberg, Denmark
*
*Corresponding author: Anette Pedersen, fax +45 3528 2469, email [email protected]
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Abstract

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There is increasing evidence that the degree of postprandial lipaemia may be of importance in the development of atherosclerosis and IHD. Postprandial lipid, lipoprotein, glucose, insulin and non-esterified fatty acid (NEFA) concentrations were investigated in eleven healthy young males after randomized ingestion of meals containing rapeseed oil, sunflower oil or palm oil with or without a glucose drink. On six occasions each subject consumed consecutive meals (separated by 1·75 h) containing 70 g (15 g and 55 g respectively) of each oil. On one occasion with each oil 50 g glucose was taken with the first meal. One fasting and fifteen postprandial blood samples were taken over 9 h. There were no statistically significant differences in lipoprotein and apolipoprotein responses after rapeseed, sunflower and palm oils, whereas insulin responses were lower after sunflower oil than after rapeseed oil (ANOVA, P = 0·04). The NEFA and triacylglycerol concentrations at 1·5 h were reduced when 50 g glucose was taken with the first meal (ANOVA, P < 0·0001 and P < 0·05 respectively), regardless of meal fatty acid composition. In conclusion, the consumption of glucose with a mixed meal containing either rapeseed, sunflower or palm oil influenced the immediate triacylglycerol and NEFA responses compared with the same meal without glucose, whereas no significant effect on postprandial lipaemia after a subsequent meal was observed. The fatty acid composition of the meal did not significantly affect the lipid and lipoprotein responses, whereas an effect on insulin responses was observed.

Keywords

Fatty acid compositionPostprandial lipaemiaGlucose
Type
Research Article
Information
British Journal of Nutrition , Volume 82 , Issue 2 , August 1999 , pp. 97 - 104
Copyright
Copyright © The Nutrition Society 1999

References

Albrink, MJ, Fitzgerald, JR & Man, EB (1958) Reduction of alimentary lipaemia by glucose. Metabolism 7, 162–171.Google ScholarPubMed
Altman, DG (1991) Practical Statistics for Medical Research, 1st ed. London: Chapman & Hall.Google Scholar
Asp, N-G, Johansson, C-G, Hallmer, H & Siljeström, M (1983) Rapid enzymatic assay of insoluble and soluble dietary fiber. Journal of Agricultural and Food Chemistry 31, 476–482.CrossRefGoogle ScholarPubMed
Binnert, C, Pachiaude, C, Beylot, M, Croset, M, Cohen, R, Riou, JP & Laville, M (1996) Metabolic fate of an oral long-chain triglyceride load in humans. American Journal of Physiology 270, E445–E450.Google ScholarPubMed
Cara, L, Dubois, C, Borel, P, Armand, M, Senft, M, Portugal, H, Pauli, A-M, Bernard, P-M & Lairon, D (1992) Effects of oat bran, rice bran, wheat fiber, and wheat germ on postprandial lipemia in healthy adults. American Journal of Clinical Nutrition 55, 81–88.CrossRefGoogle ScholarPubMed
Christopherson, SW & Glass, RL (1969) Preparation of milk fat methyl esters by alcoholysis in an essentially nonalcoholic solution. Journal of Dairy Science 52, 1289–1290.CrossRefGoogle Scholar
Cohen, JC & Berger, M (1990) Effects of glucose ingestion on postprandial lipemia and triglyceride clearance in humans. Journal of Lipid Research 31, 597–602.CrossRefGoogle ScholarPubMed
Cohen, JC, Noakes, TD & Benade, AJS (1988) Serum triglyceride responses to fatty meals: effects of meal fat content. American Journal of Clinical Nutrition 47, 825–827.CrossRefGoogle ScholarPubMed
Cohen, JC & Schall, R (1988) Reassessing the effects of simple carbohydrates on the serum triglyceride responses to fat meals. American Journal of Clinical Nutrition 48, 1031–1034.CrossRefGoogle ScholarPubMed
Cohn, JS, McNamara, JR, Cohn, SD, Ordovas, JM & Schaefer, EJ (1988) Postprandial plasma lipoprotein changes in human subjects of different ages. Journal of Lipid Research 29, 469–479.CrossRefGoogle ScholarPubMed
Coppack, SW, Jensen, MD & Miles, JM (1994) In vivo regulation of lipolysis in humans. Journal of Lipid Research 35, 177–193.CrossRefGoogle ScholarPubMed
Demacker, PNM, Reijnen, IGM, Katan, MB, Stuyt, PMJ & Stalenhoef, AFH (1991) Increased removal of remnants of triglyceride-rich lipoproteins on a diet rich in polyunsaturated fatty acids. European Journal of Clinical Investigation 21, 197–203.CrossRefGoogle Scholar
De Bruin, TWA, Brouwer, CB, Gimpel, JAH & Erkelens, DW (1991) Postprandial decrease in HDL cholesterol and HDL apo A-1 in normal subjects in relation to triglyceride metabolism. American Journal of Physiology 260, E492–E498.Google ScholarPubMed
De Bruin, TWA, Brouwer, CB, Van Linde-Sibenius, M, Jansen, H & Erkelens, DW (1993) Different postprandial metabolism of olive oil and soybean oil: a possible mechanism of the high-density lipoprotein conserving effect of olive oil. American Journal of Clinical Nutrition 58, 477–483.CrossRefGoogle ScholarPubMed
Dole, PV & Hamlin, JT (1962) Particulate fat in lymph and blood. Physiological Reviews 42, 674–701.CrossRefGoogle ScholarPubMed
Dubois, C, Armand, M, Azais-Braesco, V, Portugal, H, Pauli, A-M, Bernard, P-M, Latgé, C, Lafont, H, Borel, P & Lairon, D (1994) Effects of moderate amounts of emulsified dietary fat on postprandial lipemia and lipoproteins in normolipidemic adults. American Journal of Clinical Nutrition 60, 374–382.CrossRefGoogle ScholarPubMed
Dubois, C, Armand, M, Senft, M, Portugal, H, Pauli, A-M, Bernard, P-M, Lafont, H & Lairon, D (1995) Chronic oat bran intake alters postprandial lipemia and lipoproteins in healthy adults. American Journal of Clinical Nutrition 61, 325–333.CrossRefGoogle ScholarPubMed
Dubois, C, Beaumier, G, Juhel, C, Armand, M, Portugal, H, Pauli, A-M, Borel, P Latgé C & Lairon, D (1998) Effects of graded amounts (0–50 g) of dietary fat on postprandial lipemia and lipoproteins in normolipidemic adults. American Journal of Clinical Nutrition 67, 31–38.CrossRefGoogle ScholarPubMed
Folch, J, Lees, M & Stanley, GHS (1957) A simple method for the isolation and purification of total lipides from animal tissues. Journal of Biological Chemistry 226, 497–509.CrossRefGoogle ScholarPubMed
Frape, DL, Williams, NR, Scriven, AJ, Palmer, CR, O'Sullivan, K & Fletcher, RJ (1997) Diurnal trends in responses of blood plasma concentrations of glucose, insulin, and C-peptide following high- and low-fat meals and their relation to fat metabolism in healthy middle-aged volunteers. British Journal of Nutrition 77, 523–535.CrossRefGoogle ScholarPubMed
Frayn, KN (1993) Insulin resistance and lipid metabolism. Current Opinion in Lipidology 4, 197–204.CrossRefGoogle Scholar
Frayn, KN, Shadid, S, Hamlani, R, Humphreys, SM, Clark, ML, Fielding, BA, Boland, O & Coppack, SW (1994) Regulation of fatty acid movement in human adipose tissue in the postabsorptive-to-postprandial transition. American Journal of Physiology 266, E308–E317.Google ScholarPubMed
Frayn, KN, Williams, CM & Arner, P (1996) Are increased plasma non-esterified fatty acid concentrations a risk marker for coronary heart disease and other chronic diseases?. Clinical Science 90, 243–253.CrossRefGoogle ScholarPubMed
Groot, PHE, van Stiphout, WAHJ, Krauss, XH, Jansen, H, van Tol, A, van Ramshorst, E, Chin-On, S, Hofman, A, Cresswell, SR & Havekes, L (1991) Postprandial lipoprotein metabolism in normolipidemic men with and without coronary artery disease. Arteriosclerosis and Thrombosis 11, 653–662.CrossRefGoogle ScholarPubMed
Harris, WS, Connor, WE, Alam, N & Illingworth, DR (1988) Reduction of postprandial triglyceridemia in humans by dietary n-3 fatty acids. Journal of Lipid Research 29, 1451–1460.CrossRefGoogle ScholarPubMed
Jenkins, DJ, Wolever, TM, Taylor, RH, Griffiths, C, Krzeminska, K, Lawrie, JA, Bennett, CM, Goff, DV, Sarson, DL & Bloom, SR (1982) Slow release dietary carbohydrate improves second meal tolerance. American Journal of Clinical Nutrition 35, 1339–1346.CrossRefGoogle ScholarPubMed
Joannic, J-L, Auboiron, S, Raison, J, Basdevant, A, Bornet, F & Guy-Grand, B (1997) How the degree of unsaturation of dietary fatty acids influences the glucose and insulin responses to different carbohydrates in mixed meals. American Journal of Clinical Nutrition 65, 1427–1433.CrossRefGoogle ScholarPubMed
Karpe, F (1997) Postprandial lipid metabolism in relation to coronary heart disease. Proceedings of the Nutrition Society 56, 671–678.CrossRefGoogle ScholarPubMed
Karpe, F, Bell, M, Bjorkegren, J & Hamsten, A (1995) Quantification of postprandial triglyceride-rich lipoproteins in healthy men by retinyl ester labeling and simultaneous measurement of apolipoproteins B-48 and B-100. Arteriosclerosis, Thrombosis and Vascular Biology 15, 199–207.CrossRefGoogle Scholar
Kirsten, WJ & Hesselius, GU (1983) Rapid, automatic, high capacity Dumas determination of nitrogen. Microchemical Journal 28, 529–547.CrossRefGoogle Scholar
Lairon, D (1996) Dietary fibres: effects on lipid metabolism and mechanisms of action. European Journal of Clinical Nutrition 50, 125–133.Google ScholarPubMed
Mann, JI, Truswell, AS & Pimstone, BI (1971) The different effects of oral sucrose and glucose on alimentary lipaemia. Clinical Science 41, 123–129.CrossRefGoogle ScholarPubMed
Nicholls, DP & Cohen, H (1985) Effect of oral and intravenous glucose on alimentary lipaemia in normal man. Irish Journal of Medical Science 154, 348–353.CrossRefGoogle ScholarPubMed
Nikkila, EA & Pelkonen, R (1966) Enhancement of alimentary hyperglyceridemia by fructose and glycerol in man. Proceedings of the Society for Experimental Biology and Medicine 123, 91–94.CrossRefGoogle ScholarPubMed
Nilsson-Ehle, P, Carlström, S & Belfrage, P (1975) Rapid effects on lipoprotein lipase activity in adipose tissue of humans after carbohydrate and lipid intake. Time course and relation to plasma glycerol, triglyceride, and insulin levels. Scandinavian Journal of Clinical and Laboratory Investigation 35, 373–378.CrossRefGoogle Scholar
Patsch, JR, Miesenböck, G, Hopferwieser, T, Mühlberger, V, Knapp, E, Dun, JK, Gotto, AM & Patsch, W (1992) Relation of triglyceride metabolism and coronary artery disease. Studies in the postprandial state. Arteriosclerosis and Thrombosis 12, 1336–1345.CrossRefGoogle ScholarPubMed
Rasmussen, O, Lauszus, FF, Christiansen, C, Thomsen, C & Hermansen, K (1996) Differential effects of saturated and monounsaturated fat on blood glucose and insulin responses in subjects with non-insulin-dependent diabetes mellitus. American Journal of Clinical Nutrition 63, 249–253.CrossRefGoogle ScholarPubMed
Sadur, CN & Eckel, RH (1982) Insulin stimulation of adipose tissue lipoprotein lipase. Use of the euglycemic clamp technique. Journal of Clinical Investigation 69, 1119–1125.CrossRefGoogle ScholarPubMed
Sandström, B, Hansen, LT & Sørensen, A-M (1994) Pea fiber lowers fasting and postprandial blood triglyceride concentrations in humans. Journal of Nutrition 124, 2386–2396.CrossRefGoogle ScholarPubMed
Simpson, HS, Williamson, CM, Olivecrona, T, Pringle, S, Maclean, J, Lorimer, AR, Bonnefous, F, Bogaievsky, Y, Packard, CJ & Shepherd, J (1990) Postprandial lipemia, fenofibrate and coronary artery disease. Atherosclerosis 85, 193–202.CrossRefGoogle ScholarPubMed
Stensvold, I, Tverdal, A, Urdal, P & Graff-Iversen, S (1993) Non-fasting serum triglyceride concentration and mortality from coronary heart disease and any cause in middle aged Norwegian women. British Medical Journal 307, 1318–1322.CrossRefGoogle ScholarPubMed
Tall, AR (1993) Plasma cholesteryl ester transfer protein. Journal of Lipid Research 34, 1255–1274.CrossRefGoogle ScholarPubMed
Trinick, TR, Laker, MF, Johnston, DG, Keir, M, Buchanan, KD & Alberti, KG (1986) Effect of guar on second-meal glucose tolerance in normal man. Clinical Science 71, 49–55.CrossRefGoogle ScholarPubMed
Weintraub, MS, Zechner, R, Brown, A, Eisenberg, S & Breslow, JL (1988) Dietary polyunsaturated fats of the ?-6 and ?-3 series reduce postprandial lipoprotein levels. Journal of Clinical Investigation 82, 1884–1893.CrossRefGoogle ScholarPubMed
Williams, CM (1997) Postprandial lipid metabolism: effects of dietary fatty acids. Proceedings of the Nutrition Society 56, 679–692.CrossRefGoogle ScholarPubMed
Wolever, TM, Jenkins, DJ, Ocana, AM, Rao, VA & Collier, GR (1988) Second-meal effect: low-glycemic-index foods eaten at dinner improve subsequent breakfast glycemic response. American Journal of Clinical Nutrition 48, 1041–1047.CrossRefGoogle ScholarPubMed
Zampelas, A, Peel, AS, Gould, BJ, Wright, J & Williams, CM (1994) Polyunsaturated fatty acids of the n-6 and n-3 series: effects on postprandial lipid and apolipoprotein levels in healthy men. European Journal of Clinical Nutrition 48, 842–848.Google ScholarPubMed
Zilversmit, DB (1979) Atherogenesis: A postprandial phenomenon. Circulation 60, 473–485.CrossRefGoogle ScholarPubMed