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Polyunsaturated fatty acid concentrations in young men and women consuming their habitual diets

Published online by Cambridge University Press:  08 March 2007

Lucy Bakewell ,
Graham C. Burdge  and
Philip C. Calder
Lucy Bakewell
Affiliation:
Institute of Human Nutrition, Developmental Origins of Health and Disease Division, University of Southampton, Southampton SO16 7PX, UK
Graham C. Burdge*
Affiliation:
Institute of Human Nutrition, Developmental Origins of Health and Disease Division, University of Southampton, Southampton SO16 7PX, UK
Philip C. Calder
Affiliation:
Institute of Human Nutrition, Developmental Origins of Health and Disease Division, University of Southampton, Southampton SO16 7PX, UK
*
*Corresponding author: Dr G. C. Burdge, fax +44 (0)238 04379, email [email protected]
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Abstract

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Young women of reproductive age appear to have a greater capacity than men to convert the essential fatty acid α-linolenic acid to DHA. The purpose of this study was to test the hypothesis that gender-related differences in n-3 PUFA metabolism are reflected in the concentrations of n-3 PUFA in plasma lipids. The subjects were healthy men (n 13) and women (n 23) aged 18–35 years consuming their habitual diet. Dietary habits were assessed by food-frequency questionnaire. Venous blood samples were collected following an overnight fast. For the women, blood collection took place on the tenth day of their menstrual cycle. The fatty acid concentrations of plasma phosphatidylcholine, triacylglycerol, NEFA and cholesteryl esters were determined by gas chromatography. There were no significant differences between men and women in their consumption of protein, carbohydrate, total fat, alcohol, individual fatty acids and selected micronutrients. DHA concentration alone was significantly higher in plasma phosphatidylcholine (31%, p=0·02), triacylglycerol (71%, p=0·02) and NEFA (33%, p=0·01), but not cholesteryl esters, in women compared with men. There were no significant differences between men and women in the concentrations of any other fatty acids measured. Overall, the present data support the suggestion that greater DHA synthesis in women than men results in a higher DHA concentration in plasma lipids.

Keywords

Docosahexaenoic acidBloodGenderPolyunsaturated fatty acids
Type
Research Article
Information
British Journal of Nutrition , Volume 96 , Issue 1 , January 2006 , pp. 93 - 99
Copyright
Copyright © The Nutrition Society 2006

References

Al, MD, van Houwelingen, AC & Hornstra, GRelation between birth order and the maternal and neonatal docosahexaenoic acid status. Eur J Clin Nutr (1997) 51, 548–553.CrossRefGoogle ScholarPubMed
Bingham, SA, Gill, C, Welch, A, Day, K, Cassidy, A, Khaw, KT, Sneyd, MJ, Key, TJA, Roe, L & Day, NEComparison of dietary assessment methods in nutritional epidemiology; weighed records v. 24 h recalls, food-frequency questionnaires and estimated-diet records. Br J Nutr (1994) 72, 619–643.CrossRefGoogle ScholarPubMed
Bolton-Smith, C, Woodward, M & Tavendale, REvidence for age-related differences in the fatty acid composition of human adipose tissue, independent of diet. Eur J Clin Nutr (1997) 51, 619–624.CrossRefGoogle ScholarPubMed
Bulow, J, Simonsen, L, Wiggins, D, Humphreys, SM, Frayn, KN, Powell, D & Gibbons, GFCo-ordination of hepatic and adipose tissue lipid metabolism after oral glucose. J Lipid Res (1999) 40, 2034–2043.CrossRefGoogle ScholarPubMed
Burdge, Ga-Linolenic acid metabolism in men and women: nutritional and biological implications. Curr Opin Clin Nutr Metab Care (2004) 7, 137–144.CrossRefGoogle Scholar
Burdge, GC, Finnegan, YE, Minihane, AM, Williams, CM & Wootton, SAEffect of altered dietary n-3 fatty acid intake upon plasma lipid fatty acid composition, conversion of [13C] alpha-linolenic acid to longer-chain fatty acids and partitioning towards-oxidation in older men. Br J Nutr (2003) 90, 311–321.CrossRefGoogle ScholarPubMed
Burdge, GC, Hunt, AN & Postle, ADMechanisms of hepatic phosphatidylcholine synthesis in adult rat: effects of pregnancy. Biochem J (1994) 303, 941–947.CrossRefGoogle ScholarPubMed
Burdge, GC, Jones, AE, & Wootton, SAEicosapentaenoic and docosapentaenoic acids are the principal products of a-linolenic acid metabolism in young men. Br J Nutr (2002) 88, 355–363.CrossRefGoogle Scholar
Burdge, GC, & Postle, ADHepatic phospholipid molecular species in the guinea pig. Adaptations to pregnancy. Lipids (1994) 29, 259–264.CrossRefGoogle ScholarPubMed
Burdge, GC, & Postle, ADPregnancy-associated adaptations to hepatic phosphatidylcholine biosynthesis in the guinea-pig. Comp Biochem Physiol (1998) 119B, 265–272.CrossRefGoogle Scholar
Burdge, GC, & Wootton, SAConversion of a-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women. Br J Nutr (2002) 88, 411–420.CrossRefGoogle Scholar
Burdge, GC, Wright, P, Jones, AE & Wootton, SAA method for separation of phosphatidylcholine, triacylglycerol, non-esterified fatty acids and cholesterol esters from plasma by solid-phase extraction. Br J Nutr (2000) 84, 781–787.CrossRefGoogle ScholarPubMed
Calder, PCn-3 polyunsaturated fatty acids and inflammation: from molecular biology to the clinic. Lipids (2003) 38, 342–352.CrossRefGoogle ScholarPubMed
Emken, EA, Adlof, RO, & Gulley, RMDietary linoleic acid influences desaturation and acylation of deuterium-labeled linoleic and linolenic acids in young adult males. Biochim Biophys Acta (1994) 1213, 277–288.CrossRefGoogle ScholarPubMed
Folch, JL, Lees, M & Sloane-Stanley, GHA simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem (1957) 226, 497–509.CrossRefGoogle ScholarPubMed
Giltay, EJ, Duschek, EJ, Katan, MB, Zock, PL, Neele, SJ & Netelenbos, JCRaloxifene and hormone replacement therapy increase arachidonic acid and docosahexaenoic acid levels in postmenopausal women. J Endocrinol (2004a) 182, 399–408.CrossRefGoogle ScholarPubMed
Giltay, EJ, Gooren, LJ, Toorians, AW, Katan, MB & Zock, PLDocosahexaenoic acid concentrations are higher in women than in men because of estrogenic effects. Am J Clin Nutr (2004b) 80, 1167–1174.CrossRefGoogle ScholarPubMed
Henderson, L, Gregory, J, Irving, K & Swan, GNational Diet and Nutrition Survey: Adults Aged 19 to 64 Years, vol. 2, Energy, Protein, Carbohydrate, Fat and Alcohol Intake. London:. The Stationery Office. (2003a).Google Scholar
Henderson, L, Irving, K, Gregory, J, Bates, CJ, Prentice, A, Perks, J, Swan, G & Farron, MNational Diet and Nutrition Survey: Adults Aged 19 to 64 Years, vol. 3, Vitamin and Mineral Intake and Urinary Analytes. London:. The Stationery Office. (2003b).Google Scholar
Herrera, EMetabolic adaptations in pregnancy and their implications for the availability of substrates to the fetus. Eur J Clin Nutr 54, Suppl (2000) 1, S47–S51.CrossRefGoogle ScholarPubMed
Hussein, N, Ah-Sing, E, Wilkinson, P, Leach, C, Griffin, BA & Millward, DJRelative rates of long chain conversion of 13C linoleic and a-linolenic acid in response to marked changes in their dietary intake in male adults. J Lipid Res (2005) 46, 269–280.CrossRefGoogle Scholar
Innis, SMThe role of dietary n-6 and n-3 fatty acids in the developing brain. Dev Neurosci (2000) 22, 474–480.CrossRefGoogle ScholarPubMed
Lewis, RA, Austen, KF & Soberman, RJLeukotrienes and other products of the 5-lipoxygenase pathway. Biochemisty and relation to pathobiology in human diseases. N Engl J Med (1990) 323, 645–655.Google Scholar
Mattsson, LA, Silfverstolpe, G & Samsioe, GFatty acid composition of serum lecithin and cholesterol ester in the normal menstrual cycle. Horm Metab Res (1985) 17, 414–417.CrossRefGoogle ScholarPubMed
Ministry of Agriculture, Fisheries and Food Dietary Intake of Iodine and Fatty Acids. Food Information Surveillance Sheet 127. London:. Ministry of Agriculture, Fisheries and Food. 1997.Google Scholar
Mitchell, DC, Niu, SL & Litman, BJEnhancement of G proteincoupled signalling by DHA phospholipids. Lipids (2003) 38, 437–443.CrossRefGoogle ScholarPubMed
Otto, SJ, Houwelinger, AC, Antal, M, Manninen, A, Godfrey, K, Lopez-Varamillo, P & Hornstra, GMaternal and neonatal essential fatty acid status in phospholipids: an international comparative study. Eur J Clin Nutr (1917) 51, 232–242.CrossRefGoogle Scholar
Ottosson, UB, Lagrelius, A, Rosing, U & von Schoultz, BRelative fatty acids composition of lecithin during postmenopausal replacement therapy – a comparison between ethinyl estradiol and estradiol valerate. Gynecol Obstet Invest (1984) 18, 296–302.CrossRefGoogle ScholarPubMed
Pawlosky, R, Hibbeln, J, Lin, Y & Salem, Nn-3 fatty acid metabolism in women. Br J Nutr (2003) 90, 993–994.CrossRefGoogle ScholarPubMed
Postle, AD, Al, MDM, Burdge, GC & Hornstra, GThe composition of individual molecular species of plasma phosphatidylcholine in human pregnancy. Early Hum Dev (1995) 43, 47–58.CrossRefGoogle ScholarPubMed
Silfverstolpe, G, Johnson, P, Samsice, G, Svanborg, A & Gustafson, AEffects induced by two different estrogens on serum individual phospholipids and serum lecithin fatty acid composition. Horm Metab Res (1981) 13, 141–145.CrossRefGoogle ScholarPubMed
Sprecher, HThe roles of anabolic and catabolic reactions in the synthesis and recycling of polyunsaturated fatty acids. Prostaglandins Leukot Essent Fatty Acids (2002) 67, 79–83.CrossRefGoogle ScholarPubMed
Stark, KD, Beblo, S, Murthy, M et al. ,. Comparison of bloodstream fatty acid composition from African-American women at gestation, delivery, and postpartum. J Lipid Res (2005) 46, 516–525.CrossRefGoogle ScholarPubMed
Tavendale, R, Lee, AJ, Smith, WC & Tunstall-Pedoe, HAdipose tissue fatty acids in Scottish men and women: results from the Scottish Heart Health Study. Atherosclerosis (1992) 94, 161–169.CrossRefGoogle ScholarPubMed
Tilley, SL, Coffman, TM & Koller, BHMixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes. J Clin Invest (2001) 108, 15–23.CrossRefGoogle Scholar
Welch, AA, Luben, R, Khaw, KT & Bingham, SAThe CAFE computer program for nutritional analysis of the EPIC-Norfolk food frequency questionnaire and identification of extreme nutrient values. J Hum Nutr Diet (2005) 18, 99–106.CrossRefGoogle ScholarPubMed
Welch, AA, Lund, E, Amiano, P et al. ,. Variability of fish consumption within the 10 European countries participating in the European Investigation into Cancer and Nutrition (EPIC) study. Public Health Nutr (2002) 5, 1273–1285.CrossRefGoogle ScholarPubMed