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Paradoxical effects of essential fatty acid supplementation on lipid profiles and sweat electrolytes in cystic fibrosis

Published online by Cambridge University Press:  09 March 2007

John A. Dodge ,
Jacqueline M. Custance ,
Mary C. Goodchild ,
Sheena C. Laing  and
Merle Vaughan
John A. Dodge
Affiliation:
Department of Child Health, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN
Jacqueline M. Custance
Affiliation:
Department of Child Health, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN
Mary C. Goodchild
Affiliation:
Department of Child Health, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN
Sheena C. Laing
Affiliation:
Department of Child Health, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN
Merle Vaughan
Affiliation:
Department of Child Health, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN
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Abstract

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Supplements of evening primrose oil (Oenothera biennis), which contains at least 72% linoleic (18:2n−6) and 7% γ-linolenic (18:3 n−6) acids (expressed as % fatty acid methyl esters) were given to sixteen cystic fibrosis patients for a period of 12 months. Clinical observations showed no significant changes in patients' weights or respiratory function throughout. Linoleic acid levels in plasma and erythrocyte membranes increased significantly during the first 6 months but this increase was not sustained at its initial level. After supplementation was discontinued reversion to baseline (low) levels occurred within 4 months. Levels of plasma prostaglandins (PG) and urinary PG metabolites varied among individuals over a wide range, and urinary PGF2α metabolites fell during the supplementation. There was a significant fall in sweat sodium concentrations after 6 weeks of supplementation, but sweat chloride was unchanged. It is not known whether the effect of essential fatty acids on sweat Na+ reflects changes in cell membrane conformation or if there is a direct effect on Na+ pump activity.

Keywords

Cystic fibrosisEssential fatty acidsSweat electrolytes
Type
Dietary lipids and Metabolism
Information
British Journal of Nutrition , Volume 63 , Issue 2 , March 1990 , pp. 259 - 271
Copyright
Copyright © The Nutrition Society 1990

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