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Paradoxical effect of ethanol on liver lipogenesis in the genetically-obese Zucker rat

Published online by Cambridge University Press:  09 March 2007

C. Karsenty ,
M. Ulmer ,
F. Chanussot ,
R. Ratanasavanh  and
G. Debry
C. Karsenty
Affiliation:
Département de Nutrition et des Maladies Métaboliques de I'Université de Nancy I et Unité de Recherches de Nutrition et Diététique de I'INSERM U.59, 40 rue Lionnois, F–54000 Nancy, France
M. Ulmer
Affiliation:
Département de Nutrition et des Maladies Métaboliques de I'Université de Nancy I et Unité de Recherches de Nutrition et Diététique de I'INSERM U.59, 40 rue Lionnois, F–54000 Nancy, France
F. Chanussot
Affiliation:
Département de Nutrition et des Maladies Métaboliques de I'Université de Nancy I et Unité de Recherches de Nutrition et Diététique de I'INSERM U.59, 40 rue Lionnois, F–54000 Nancy, France
R. Ratanasavanh
Affiliation:
Département de Nutrition et des Maladies Métaboliques de I'Université de Nancy I et Unité de Recherches de Nutrition et Diététique de I'INSERM U.59, 40 rue Lionnois, F–54000 Nancy, France
G. Debry
Affiliation:
Département de Nutrition et des Maladies Métaboliques de I'Université de Nancy I et Unité de Recherches de Nutrition et Diététique de I'INSERM U.59, 40 rue Lionnois, F–54000 Nancy, France
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Abstract

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1. Sixteen obese (fa/fa) Zucker rats, sixteen lean (Fa/-)Zucker rats and sixteen Wistar rats, all male rats aged 7–8 weeks, were given either a control (C) diet containing no ethanol or an ethanol (E) diet in which 36% of the energy was supplied by ethanol, for a period of 4 weeks.

2. The activities of glucose-6-phosphate dehydrogenase (EC 1.1.1.49), glucose-6-phosphatase (EC 3.1.3.9) and glycerol kinase (EC 2.7.1.30) and the glycogen content in the livers of obese (fa/fa)rats were lower in animals given diet E than in those given diet C. As a result, hepatic lipogenesis and fatty degeneration of the liver were reduced in obese (fa/fa) rats given diet E.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 54 , Issue 1 , July 1985 , pp. 15 - 20
Copyright
Copyright © The Nutrition Society 1985

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