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Orexins, feeding and the big picture

Published online by Cambridge University Press:  09 March 2007

Jonathan Arch
Affiliation:
Director Vascular Biology, SmithKline Beecham Pharmaceuticals, NFSP (N), Coldharbour Road, Harlow, Essex CM19 5AD, United Kingdom
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Abstract

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Type
Invited Commentary
Copyright
Copyright © The Nutrition Society 2000

References

Arch, JRS (2000) The role of orexins in the regulation of feeding: a perspective. Regulatory Peptides 89, 79.Google Scholar
Arch, JRS, Williams, G and Wilson, S (1999) Orexins and obesity. Neuroscience News 2, 3742.Google Scholar
Cai, XJ, Widdowson, PS, Harrold, J, Evans, M, Leslie, R, Wilson, S, Buckingham, RE, Arch, JRS, Tadayyon, M, Clapham, JC, Wilding, J, Cutler, DJ and Williams, G (1999) Hypothalamic orexin expression: modulation by blood glucose and feeding. Diabetes 48, 21322137.CrossRefGoogle ScholarPubMed
Cone, RD (1999) The central melanocortin system and energy homeostasis. Trends in Endocrinology & Metabolism 10, 211216.CrossRefGoogle ScholarPubMed
de Lecea, L, Kilduff, TS, Peyron, C, Gao, XB, Foye, PE, Danielson, PE, Fukuhara, C, Battenberg, ELF, Gautvik, VT, Bartlett, FS, Frankel, WN, Vandenpol, AN, Bloom, FE, Gautvik, KM and Sutcliffe, JG (1998) The hypocretins – hypothalamus-specific peptides with neuroexcitatory activity. Proceedings of the National Academy of Science, USA 95, 322327.CrossRefGoogle ScholarPubMed
Elias, CF, Saper, CB, Maratos-Flier, E, Tritos, NA, Lee, C, Kelly, J, Tatro, JB, Hoffman, GE, Ollmann, MM, Barsh, GS, Sakurai, T, Yanagisawa, M and Elmquist, JK (1998) Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area. Journal of Comparative Neurology 402, 442459.3.0.CO;2-R>CrossRefGoogle ScholarPubMed
Hagan, JJ, Leslie, R, Patel, S, Evans, ML, Wattam, TA, Holmes, SD, Benham, CD, Taylor, SG, Routledge, C, Hemmati, P, Munton, RP, Ashmeade, TE, Shah, AS, Hatcher, JP, Hatcher, PD, Jones, DNC, Smith, MI, Piper, DC, Hunter, AJ, Porter, RA and Upton, N (1999) Orexin-A activates locus coeruleus cell firing and increases arousal in the rat. Proceedings of the National Academy of Science, USA 96, 1091110916.CrossRefGoogle ScholarPubMed
Haynes, AC, Jackson, B, Overend, P, Buckingham, RE, Wilson, S, Tadayyon, M and Arch, JRS (1999) Effects of single and chronic ICV administration of the orexins on feeding in the rat. Peptides 20, 10991105.Google Scholar
Horvath, TL, Diano, S and van den Pol, AN (1999) Synaptic interaction between hypocretin (orexin) and neuropeptide Y cells in the rodent and primate hypothalamus: a novel circuit implicated in metabolic and endocrine regulations. Journal of Neuroscience 19, 10721087.CrossRefGoogle ScholarPubMed
Inui, A (1999) Feeding and body-weight regulation by hypothalamic neuropeptides - mediation of the actions of leptin. Trends in Neurosciences 22, 6267.CrossRefGoogle ScholarPubMed
Kalra, SP, Dube, MG, Pu, S, Xu, B, Horvath, TL and Kalra, PS (1999) Interacting appetite-regulating pathways in the hypothalamic regulation of body weight. Endocrine Reviews 20, 68100.Google ScholarPubMed
Kastin, AJ and Akerstrom, V (1999) Orexin A but not orexin B rapidly enters brain from blood by simple diffusion. Journal of Pharmacology and Experimental Therapeutics 289, 219223.Google Scholar
Kirchgessner, AL and Liu, M-T (1999) Orexin synthesis and response in the gut. Neuron 24, 941951.CrossRefGoogle ScholarPubMed
López, M, Seoane, L, del Carmen, García M, Lago, F, Casaneuva, FF, Señarís, R and Diéguez, C (2000) Leptin regulation of prepro-orexin and orexin receptor mRNA levels in the hypothalamus. Biochemical and Biophysical Research Communications 269, 4145.CrossRefGoogle ScholarPubMed
Nowak, KW, Mackowiak, P, Switonska, MM, Fabis, M and Malendowicz, LK (2000) Acute orexin effects on insulin secretion in the rat:. In vivo and. in vitro studies. Life Sciences 66, 449454.CrossRefGoogle ScholarPubMed
Rodgers, RJ, Halford, JCG, Nunes de Souza, RL, Canto de Souza, AL, Piper, DC, Arch, JRS and Blundell, JE (2000) Profiling the behavioural effects of orexin-A in rats. Regulatory Peptides 89, 79.Google Scholar
Sakurai, T, Amemiya, A, Ishii, M, Matsuzaki, I, Chemelli, RM, Tanaka, H, Williams, SC, Richardson, JA, Kozlowski, GP, Wilson, S, Arch, JRS, Buckingham, RE, Haynes, AC, Carr, SA, Annan, RS, Mcnulty, DE, Liu, WS, Terrett, JA, Elshourbagy, NA, Bergsma, DJ and Yanagisawa, M (1998) Orexins and orexin receptors – a family of hypothalamic neuropeptides and G-protein coupled receptors that regulate feeding behaviour. Cell 92, 573585.CrossRefGoogle Scholar
Shirasaka, T, Nakazato, M, Matsukura, S, Takasaki, M and Kannan, H (1999) Sympathetic and cardiovascular actions of orexins in conscious rats. American Journal of Physiology 277, R1780R1785.Google ScholarPubMed
Smart, D, Jerman, JC, Brough, SJ, Neville, WA, Jewitt, F and Porter, RA (2000) The hypocretins are weak agonists at recombinant human orexin-1 and orexin-2 receptors. British Journal of Pharmacology 129, 12891291.CrossRefGoogle ScholarPubMed
Smart, D, Jerman, JC, Brough, SJ, Rushton, SL, Murdock, PR, Jewitt, F, Elshourbagy, NA, Ellis, CE, Middlemiss, DN and Brown, F (1999) Characterization of recombinant human orexin receptor pharmacology in a Chinese hamster ovary cell-line using FLIPR. British Journal of Pharmacology 128, 13.Google Scholar
Smith, SL, Fraser, DC, Needham, AM, Jackson, HC, Cheetham, SC and Heal, DJ (2000) Effect of central injections of anti-orexin 1 receptor antibody on food intake in rats. International Journal of Obesity 24, S37.Google Scholar
Takahashi, N, Okumura, T, Yamada, H and Kohgo, Y (1999) Stimulation of gastric acid secretion by centrally administered orexin-A in conscious rats. Biochemical and Biophysical Research Communications 254, 623627.CrossRefGoogle ScholarPubMed
Tamura, T, Irahura, M, Tezuka, M, Kiyokawa, M and Aono, T (1999) Orexins, orexigenic hypothalamic neuropeptides, suppress the pulsatile secretion of luteinizing hormone in ovariectomized female rats. Biochemical and Biophysical Research Communications 264, 759762.CrossRefGoogle ScholarPubMed
Yamada, H, Okumura, T, Motomuran, W, Kobayashi, Y and Kohgo, Y (2000) Inhibition of food intake by central injection of anti-orexin antibody in fasted rats. Biochemical and Biophysical Research Communications 267, 527531.CrossRefGoogle ScholarPubMed