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Nutrient effects on the hepatic production of somatomedin C (IGF,) in the milk-fed calf

Published online by Cambridge University Press:  09 March 2007

VÈronique Coxam ,
Dominique Bauchart ,
Denis Durand ,
Marie-jeanne Davicco ,
Fred Opmeer  and
Jean-pierre Barlet
VÈronique Coxam
Affiliation:
UA CNRS 1123, INRA Theix, F-63122 CeyratFrance
Dominique Bauchart
Affiliation:
UA CNRS 1123, INRA Theix, F-63122 CeyratFrance
Denis Durand
Affiliation:
UA CNRS 1123, INRA Theix, F-63122 CeyratFrance
Marie-jeanne Davicco
Affiliation:
UA CNRS 1123, INRA Theix, F-63122 CeyratFrance
Fred Opmeer
Affiliation:
UA CNRS 1123, INRA Theix, F-63122 CeyratFrance
Jean-pierre Barlet
Affiliation:
UA CNRS 1123, INRA Theix, F-63122 CeyratFrance
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Abstract

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The present study was aimed at determining the influence of nutrients supplied by a milk diet (glucose, amino acids, triglycerides) on hepatic somatomedin C (IGF1) production in vivo in four 30-d-old milk-fed calves fitted with chronically indwelling catheters in hepatic (HV), portal (PV) and mesenteric veins and in the hepatic artery (HA), and with electromagnetic flow-meters on HA and PV. Fasting for 16 h induced a decrease (P < 0.01) in hepatic IGF1 production (nmol/kg body-weight (BW) for 6 h) (1.1 (SE 0.2) ν. 6.6 (SE 0.7) in control animals). Infusion of glucose (1.8 g/kg BW for 4 h) or a mixture of amino acids (Azonutril; R. Bellon, Neuilly sur Seine; 62.5 mg nitrogen/kg BW for 3 h) in a mesenteric vein led to no significant effect on hepatic IGF1 production for 6 h (1.2 (SE 0.3) and 0.7 (SE 0.3) nmol/kg BW respectively) compared with fasted calves. Infusion of chylomicrons purified from milk-fed calves (10.5 mg/h per kg BW, i.e. 0.16 mg triglycerides/kg BW per min) enhanced significantly (P < 0.01) the hepatic production of IGF1 (mean value for 6 h: 5.3 (SE 0.8) nmol/kg BW). Infusion of Intralipid (7 mg triglycerides/kg BW per min) induced a slight but significant hepatic IGF1 production which amounted to 3.5 (SE 0.4) nmol/kg BW (P < 0.01 compared with chylomicron treatment) and it began only 5 h after starting the infusion. Neither triglyceride nor chylomicron infusion significantly modified hepatic blood flow. Thus, these results demonstrate for the first time the role of lipids in the regulation of hepatic IGF1 production in vivo.

Keywords

Somatomedin CCalfLiver IGF
Type
Lipids
Information
British Journal of Nutrition , Volume 62 , Issue 2 , September 1989 , pp. 425 - 437
Copyright
Copyright © The Nutrition Society 1989

References

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