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Maternal food restriction in the second half of pregnancy affects vascular function but not blood pressure of rat female offspring

Published online by Cambridge University Press:  09 March 2007

Kathleen Holemans ,
Robert Gerber ,
Kris Meurrens ,
Fred De Clerck ,
Lucilla Poston  and
F. André Van Assche
Kathleen Holemans*
Affiliation:
Department of Obstetrics and Gynecology, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
Robert Gerber
Affiliation:
Department of Obstetrics and Gynaecology, UMDS, St Thomas' Hospital, London SE1 7EH, UK
Kris Meurrens
Affiliation:
Proefdierencentrum, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
Fred De Clerck
Affiliation:
Department of Cardiovascular and Pulmonary Pharmacology, Janssen Research Foundation, 2340 Beerse, Belgium
Lucilla Poston
Affiliation:
Department of Obstetrics and Gynaecology, UMDS, St Thomas' Hospital, London SE1 7EH, UK
F. André Van Assche
Affiliation:
Department of Obstetrics and Gynecology, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
*
*Corresponding author: fax +32 1634 4205, email [email protected]
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Abstract

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Food restriction during pregnancy in rats induces intrauterine growth retardation with consequences persisting into adulthood. In the present study we have investigated the hypothesis that malnutrition in pregnant rats may lead to altered cardiovascular function in adult female offspring. Perinatal growth retardation was induced by a 50 % reduction of normal dietary intake in rats during the second half of pregnancy. Systolic and diastolic blood pressure values and heart rate were recorded in conscious female offspring (100 d old) using a femoral artery probe. No significant differences in heart rate, or in systolic and diastolic blood pressures were recorded between control offspring and offspring of nutritionally deprived rats. In order to ascertain whether cardiovascular variables in the offspring were influenced by lactation, subgroups of offspring from food-restricted dams were fostered with lactating dams fed on a normal diet. Blood pressure and heart rate were also found to be normal in these offspring. The rise in blood pressure associated with NO inhibition was similar in all groups. Isolated resistance artery function was assessed in vitro in offspring (100–120 d old) of a second group of semi-starved dams. Small mesenteric arteries from these animals showed reduced endothelium-dependent relaxation (to acetylcholine and bradykinin), but enhanced sensitivity to exogenous NO (sodium nitroprusside). We conclude that food restriction during the second half of pregnancy and/or lactation does not induce hypertension in adult offspring, but may effect subtle changes in vascular function.

Keywords

Food restrictionIntrauterine growth retardationVascular function
Type
Short communication
Information
British Journal of Nutrition , Volume 81 , Issue 1 , January 1999 , pp. 73 - 80
Copyright
Copyright © The Nutrition Society 1999

References

Aerts, LHolemans, K & Van Assche, FA (1990) Maternal diabetes during pregnancy: consequences for the offspring Diabetes and Metabolism Reviews 6, 147–167.CrossRefGoogle ScholarPubMed
Aerts, L & Van Assche, FA (1979) Is gestational diabetes an acquired condition? Journal of Developmental Physiology 1, 219–225.Google ScholarPubMed
Barker, DJ (1995) Fetal origins of coronary heart disease British Medical Journal 311, 171–174.CrossRefGoogle ScholarPubMed
Barker, DJHales, CNFall, CHOsmond, CPhipps, K & Clark, PM (1993) Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth Diabetologia 36, 62–67.Google Scholar
Campbell, DMHall, MHBarker, DJPCross, JShiell, AW & Godfrey, KM (1996) Diet in pregnancy and the offspring's blood pressure 40 years later British Journal of Obstetrics and Gynaecology 103, 273–280.CrossRefGoogle ScholarPubMed
Chen, YL & Messina, EJ (1996) Dilation of isolated skeletal muscle arterioles by insulin is endothelium dependent and nitric oxide mediated American Journal of Physiology 270, H2120–H2124.Google ScholarPubMed
Clozel, MKuhn, H & Hefti, F (1990) Effects of angiotensin converting enzyme inhibitors and of hydralazine on endothelial function in hypertensive rats Hypertension 16, 532–540.Google Scholar
Garofano, ACzernichow, P & Bréant, B (1997) In utero undernutrition impairs rat beta-cell development Diabetologia 10, 1231–1234.CrossRefGoogle Scholar
Holemans, KAerts, L & Van Assche, FA (1991) Evidence for an insulin resistance in the adult offspring of pregnant streptozotocin-diabetic rats Diabetologia 34, 81–85.CrossRefGoogle ScholarPubMed
Holemans, KGerber, RTVan Assche, FA & Poston, L (1998) Adult offspring from diabetic Wistar rats show abnormal endothelium-dependent relaxation and reduced heart rate Journal of Vascular Research 35, Suppl. 1, 6 Abstr.Google Scholar
Holemans, KSpiessens, CMeurrens, K & Van Assche, FA (1997a) Growth patterns after growth retardation in the rat: effect of pregnancy and lactation American Journal of Obstetrics and Gynecology 176, S128 Abstr.Google Scholar
Holemans, KVan Bree, RVerhaeghe, JMeurrens, K & Van Assche, FA (1997b) Maternal semistarvation and streptozotocin-diabetes in rats have different effects on the in vivo glucose uptake by peripheral tissues in their female adult offspring Journal of Nutrition 127, 1371–1376.CrossRefGoogle ScholarPubMed
Holemans, KVerhaeghe, JDequeker, J & Van Assche, FA (1996) Insulin sensitivity in adult female offspring of rats subjected to malnutrition during the perinatal period Journal of the Society for Gynecological Investigations 3, 71–77.Google ScholarPubMed
Janssen, WJVan de Water, AXhonneux, RReneman, RS Van Neuten, JM & Janssen, PAJ (1989) Nebivolol is devoid of intrinsic sympathomimetic activity European Journal of Pharmacology 159, 89–95.CrossRefGoogle Scholar
Koukkou, ELowy, C & Poston, L (1997) The offspring of diabetic rats fed a high saturated fat diet demonstrate abnormal vascular function Journal of the Society for Gynecological Investigations 4, 115A Abstr.Google Scholar
Langley, SC & Jackson, AA (1994) Increased systolic blood pressure in adult rats induced by fetal exposure to maternal low protein diets Clinical Science 86, 217–222.CrossRefGoogle ScholarPubMed
Langley-Evans, SCGardner, DS & Jackson, AA (1996a) Association of disproportionate growth of fetal rats in late gestation with raised systolic blood pressure in later life Journal of Reproduction and Fertility 106, 307–312.Google Scholar
Langley-Evans, SCGardner, DS & Jackson, AA (1996b) Maternal protein restriction influences the programming of the rat hypothalamic pituitary adrenal axis Journal of Nutrition 126, 1578–1585.CrossRefGoogle ScholarPubMed
Langley-Evans, SCWelham, JMSherman, RC & Jackson, AA (1996c) Weanling rats exposed to maternal low-protein diets during discrete periods of gestation exhibit differing severity of hypertension Clinical Science 91, 607–615.CrossRefGoogle ScholarPubMed
Leeson, CPMWhincup, PHCook, DGDonald, AEPapacosta, OLucas, A & Deanfield, JE (1997) Flow-mediated dilatation in 9–11 year old children: the influence of intrauterine and childhood factors Circulation 96, 2233–2238.CrossRefGoogle Scholar
Leon, DAKoupilova, ILithell, HOBerglund, LHohsen, RVagero, D, Lithell, UD & McKeigue, PM (1996) Failure to realise growth potential in utero and adult obesity in relation to blood pressure in 50 year old Swedish men British Medical Journal 312, 401–406.CrossRefGoogle ScholarPubMed
Luscher, TFBoulanger, CMDohi, Y & Tschudi, M (1992) Endothelium dependent regulation of resistance arteries: alterations with aging and hypertension Journal of Cardiovascular Pharmacology 19, S34–S42.Google Scholar
Matthews, JAltman, D & Campbell, M (1990) Analysis of serial measurements in medical research British Medical Journal 300, 230–235.Google Scholar
Mulvany, MJ & Halpern, W (1977) Contractile properties of small arterial resistance arteries in spontaneously hypertensive rats and normotensive rats Circulation Research 41, 19–26.CrossRefGoogle ScholarPubMed
Phillips, DIBarker, DJHales, CNHirst, S & Osmond, C (1994) Thinness at birth and insulin resistance in adult life Diabetologia 37, 150–154.CrossRefGoogle ScholarPubMed
Poston, L & Taylor, PD (1995) Endothelial-mediated vascular function in insulin-dependent diabetes mellitus Clinical Science 88, 245–255.CrossRefGoogle Scholar
Schiffers, PMHFazzi, GEJanssen, GMJUitendaal, MP Struijker Boudier, HAJ & DeMey, JGR (1994) DNA synthesis in isolated arteries of normotensive and hypertensive rats: effects of the endothelium Journal of Hypertension 12, 245–250.Google Scholar
Tribe, RM & Poston, L (1996) Oxidative stress and lipids in diabetes: a role in endothelium vasodilator dysfunction Vascular Medicine 1, 195–206.CrossRefGoogle ScholarPubMed
Woodall, SMJohnston, BMBreier, BH & Gluckman, PD (1996) Chronic maternal undernutrition in the rat leads to delayed postnatal growth and elevated blood pressure of offspring Pediatric Research 40, 438–443.CrossRefGoogle ScholarPubMed
Xhonneux, RWouters, LReneman, RS & Janssen, PAJ (1990) The L-enantiomer of nebivolol potentiates the blood pressure lowering effect of the D-enantiomer European Journal of Pharmacology 181, 261–265.Google Scholar