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Magnesium deficiency improves glucose homeostasis in the rat: studies in vivo and in isolated islets in vitro

Published online by Cambridge University Press:  09 March 2007

Marise A. B. Reis ,
Márcia Q. Latorraca ,
Everardo M. Carneiro ,
Antonio C. Boschero ,
Mário J. A. Saad ,
Lício A. Velloso  and
Felix G. R. Reyes
Marise A. B. Reis
Affiliation:
Departamento de Fisiologia e Biofisica, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil
Márcia Q. Latorraca
Affiliation:
Departamento de Nutrição e Dietética, Faculdade de Enfermagem e Nutrição (FEN), Universidade Federal de Mato Grosso, Cuiabá, MT, Brazil
Everardo M. Carneiro
Affiliation:
Departamento de Fisiologia e Biofisica, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil
Antonio C. Boschero
Affiliation:
Departamento de Fisiologia e Biofisica, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil
Mário J. A. Saad
Affiliation:
Departamento de Clínica Médica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil
Lício A. Velloso
Affiliation:
Departamento de Clínica Médica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil
Felix G. R. Reyes*
Affiliation:
Departamento de Ciência de Alimentos, Faculdade de Engenharia de Alimentos, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil
*
*Corresponding author: Dr Felix G. R. Reyes, fax +55 19 3289 2832, email [email protected]
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Abstract

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The serum mineral levels, glucose disappearance rate (kg), total area under the glucose (ΔG) and insulin (ΔI) curves, and static insulin secretion were compared among rats fed a Mg-deficient diet for 6 (DF-6) or 11 (DF-11) weeks, and rats fed a control diet for the same periods (CO-6 and CO-11 groups). No change in glucose homeostasis was observed among DF-6, CO-6 and CO-11 rats. DF-11 rats showed an elevated kg and a reduced ΔG and ΔI. For evaluating the effect of supplementation, rats fed a control or Mg-deficient diet for 6 weeks were then fed a Mg- supplemented diet for 5 weeks (SCO and SDF groups respectively). The serum Mg levels in SDF rats were similar to those in CO-11 and SCO rats, but higher than in the DF-11 group. SDF rats showed similar kg, ΔG and ΔI compared with the CO-11 and SCO groups. However, a significantly lower kg and higher ΔG and ΔI were observed in SDF compared with DF-11 rats. Basal and 8.3 mmol glucose/l-stimulated insulin secretion by islets from DF-11 rats were higher than by islets from CO-11 rats. These results indicate that moderate Mg depletion for a long period may increase the secretion and sensitivity to insulin, while Mg supplementation in formerly Mg-deficient rats may prevent the increase in sensitivity and secretion of insulin.

Keywords

Magnesium deficiencyInsulin sensitivityGlucose homeostasisRats
Type
Research Article
Information
British Journal of Nutrition , Volume 85 , Issue 5 , May 2001 , pp. 549 - 552
Copyright
Copyright © The Nutrition Society 2001

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