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Is gastric ulceration different in normal and malnourished rats?

Published online by Cambridge University Press:  08 March 2007

A. C. B. Paula ,
J. S. Gracioso ,
W. Toma ,
R. Bezerra ,
M. A. J. Saad ,
I. M. S. De Lucca ,
E. M. Carneiro  and
A. R. M. Souza Brito
A. C. B. Paula
Affiliation:
Department of Physiology and Biophysics, Institute of Biology, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil Department of Research and Graduate School (PRPPG), Sacred Heart University (USC), Bauru, São Paulo, Brazil
J. S. Gracioso
Affiliation:
Department of Physiology and Biophysics, Institute of Biology, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
W. Toma
Affiliation:
Department of Physiology and Biophysics, Institute of Biology, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
R. Bezerra
Affiliation:
Department of Internal Medicine, School of Medicine, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
M. A. J. Saad
Affiliation:
Department of Internal Medicine, School of Medicine, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
I. M. S. De Lucca
Affiliation:
Department of Histology and Embryology, Institute of Biology, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
E. M. Carneiro
Affiliation:
Department of Physiology and Biophysics, Institute of Biology, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
A. R. M. Souza Brito*
Affiliation:
Department of Physiology and Biophysics, Institute of Biology, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
*
*Corresponding author: A. R. M. Souza Brito, Departamento de Fisiologia e Biofísica, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, São Paulo, Brazil, fax +55(19)37886185, email [email protected], and [email protected]
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Abstract

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Protein malnutrition can adversely affect all tissues. The aim of the present study was to test the hypothesis that protein deprivation influences gastric ulcer formation, as well as metabolism and organ growth, in rats. In the present study, there was a significant reduction in the body and organ weight of rats fed a low-protein diet (P<0·001). Malnourished rats were less susceptible to ulceration of the gastric mucosa in ethanol and indomethacin models of acute gastric ulcers when compared with rats fed a normoproteic diet (17 % protein). Mucus production and prostaglandin E2 formation increased in malnourished rats, possibly explaining the lower number of acute ulcers in these animals. Pylorus ligature altered gastric juice composition (increased pH and gastric volume, and decreased total acid concentration) in the animal group fed a low-protein diet compared with the group fed a diet containing 17 % protein (P<0·05). The gastric mucosa was more damaged in malnourished rats than in normal rats evaluated for 14 d after acetic acid injection (P<0·001). Malnourished rats exhibited resistance to acute gastric lesions, owing to an increase in prostaglandin GE2 release and mucus secretion, which protected their gastric mucosa. This phenomenon was not seen in subchronic gastric ulceration.

Keywords

Anti-ulcer activityMalnourishmentCytoprotectionGastric ulcers
Type
Research Article
Information
British Journal of Nutrition , Volume 93 , Issue 1 , January 2005 , pp. 47 - 52
Copyright
Copyright © The Nutrition Society 2005

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