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Inverse association between coffee drinking and serum uric acid concentrations in middle-aged Japanese males

Published online by Cambridge University Press:  09 March 2007

C. Kiyohara ,
S. Kono ,
S. Honjo ,
I. Todoroki ,
Y. Sakurai ,
M. Nishiwaki ,
H. Hamada ,
H. Nishikawa ,
H. Koga  and
S. Ogawa
...Show all authors
C. Kiyohara*
Affiliation:
Department of Public Health, Faculty of Medicine, Kyushu University, Fukuoka, Japan
S. Kono
Affiliation:
Department of Public Health, Faculty of Medicine, Kyushu University, Fukuoka, Japan
S. Honjo
Affiliation:
Department of Public Health National Defence Medical College, Tokorozawa, Japan
I. Todoroki
Affiliation:
Department of Public Health National Defence Medical College, Tokorozawa, Japan
Y. Sakurai
Affiliation:
Department of Public Health National Defence Medical College, Tokorozawa, Japan
M. Nishiwaki
Affiliation:
Self-Defence Forces Fukuoka Hospital, Kasuga, Fukuoka, Japan
H. Hamada
Affiliation:
Self-Defence Forces Fukuoka Hospital, Kasuga, Fukuoka, Japan
H. Nishikawa
Affiliation:
Self-Defence Forces Kumamoto Hospital Kumamoto, Japan
H. Koga
Affiliation:
Self-Defence Forces Kumamoto Hospital Kumamoto, Japan
S. Ogawa
Affiliation:
Self-Defence Forces Sapporo Hospital Sapporo, Japan
K. Nakagawa
Affiliation:
Self-Defence Forces Central Hospital Tokyo, Japan
*
*Corresponding author: Dr Chikako Kiyohara, fax +81 92 642 6115, email [email protected]
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Abstract

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Consumption of caffeine-rich beverages, which have diuretic properties, may decrease serum uric acid concentrations. We examined cross-sectionally the relationship of coffee and green tea consumption to serum uric acid concentrations in 2240 male self-defence officials who received a pre-retirement health examination at four hospitals of the Self-Defence Forces between 1993 and 1994. The mean levels of coffee and green tea consumption were 2·3 and 3·1 cups/d respectively. There was a clear inverse relationship between coffee consumption and serum uric acid concentration. When adjusted for hospital only, those consuming less than one cup of coffee daily had a mean serum uric acid concentration of 60 mg/l, while that of those drinking five or more cups of coffee daily was 56 mg/l (P < 0·0001). No such relationship was observed for green tea, another major dietary source of caffeine in Japan. The relationship between coffee consumption and serum uric acid concentration was independent of age, rank in the Self-Defence Forces, BMI, systolic blood pressure, serum creatinine, serum total cholesterol and serum HDL-cholesterol concentrations, smoking status, alcohol use, beer consumption and intake of dairy products. These findings suggest that coffee drinking may be associated with lower concentrations of serum uric acid, and further studies are needed to confirm the association.

Keywords

Serum uric acidCoffeeGreen teaCaffeine
Type
Research Article
Information
British Journal of Nutrition , Volume 82 , Issue 2 , August 1999 , pp. 125 - 130
Copyright
Copyright © The Nutrition Society 1999

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