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Influence of folic acid supplements on the carry-over of folates from the sow to the piglet

Published online by Cambridge University Press:  09 March 2007

B. Barkow ,
J. J. Matte ,
H. Böhme  and
G. Flachowsky
B. Barkow
Affiliation:
Institute of Animal Nutrition, Federal Agricultural Research Centre, Bundesallee 50, 38116 Braunschweig, Germany
J. J. Matte
Affiliation:
Dairy and Swine Research and Development Centre, Lennoxville (Quebec), Canada J1M 1Z3
H. Böhme
Affiliation:
Institute of Animal Nutrition, Federal Agricultural Research Centre, Bundesallee 50, 38116 Braunschweig, Germany
G. Flachowsky*
Affiliation:
Institute of Animal Nutrition, Federal Agricultural Research Centre, Bundesallee 50, 38116 Braunschweig, Germany
*
*Corresponding author: Professor G. F;achowsky fax +49 531 596 376 email: [email protected]
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Abstract

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This experiment aimed to investigate the influence of folic acid supplements on the carry-over of folates from the sow to the fetus during late gestation and to the suckling piglet. Two groups of sixteen German Landrace sows received, during gestation and lactation, a diet supplemented with either 0 or 10 mg folic acid/kg. Increased folic acid concentrations in the serum of sows were detected only at the end of gestation (day 100) and at the end of lactation (day 28). The supplementation with folic acid to the sows' diet improved the folic acid supply of the fetus compared with unsupplemented controls; values were respectively 92.6 v. 56.2 nmol folates/l serum in newborn piglets and 171.9 v. 76.3 μmol folates/g fresh liver in stillborn piglets (P < 0.05). Folate concentrations in colostrum and milk (day 28) were 3.6- and 5.0-times higher in supplemented than unsupplemented sows. This treatment effect was also reflected in the serum of piglets until weaning. Therefore, the folic acid supply for the suckling piglet is dependent mainly upon the carry-over of maternal folates via colostrum and milk.

Keywords

Folic acidSowPiglet
Type
Research Article
Information
British Journal of Nutrition , Volume 85 , Issue 2 , February 2001 , pp. 179 - 184
Copyright
Copyright © The Nutrition Society 2001

References

Bässler, K.H. (1997) Vitamin-lexicon for physicians, pharmacrits and nutritionists. 2nd ed., Frankfurt (Main): Govi-Verlag, pp. 104–136.Google Scholar
Cerna, J & Kas, J (1983) New conception of folacin assay in starch or glycogen containing food samples Nahrung 27, 957–964.CrossRefGoogle Scholar
Dumoulin, PG, Girard, CL, Matte, JJ & St-Laurent, GJ (1991) Effects of parenteral supplement of folic acid and its interaction with level of feed intake on hepatic tissues and growth performance of young dairy heifers. Journal of Animal Science 69, 1657–1666.CrossRefGoogle ScholarPubMed
Duquette, J, Matte, JJ, Farmer, C, Girard, CL & Laforest, J-P (1997) Pre- and post-mating dietary supplements of folic acid and uterin secretory activity in gilts. Canadian Journal of Animal Science 77, 415–420.CrossRefGoogle Scholar
Ek, J & Magnus, EM (1981) Plasma, red blood cell folate during normal pregnancies. Acta Obstetricia et Gynaecologica Scandinavica 60, 247–251.CrossRefGoogle ScholarPubMed
Fuchs, B, Orda, J & Wilieczkiewicz, A (1996) Effect of folic acid supplementation in pregnant sows on the fetal mortality. Medycyna Weterynarya Warschau 52, 293–298.Google Scholar
German Society of Nutrition Physiology (1987) Energy and nutrient requirements. of domestic animals. Vol. 4, Pigs 4. Frankfurt (Main): DLG-Verlag.Google Scholar
Giguere, et al. (1999) Folic acid, uterus conditioning and control of the reproductive performance of nulliparous sows. Journées de la Recherche Procine en France 31, 33-38.Google Scholar
Girard, CL & Matte, JJ (1989) Serum folates in gestating and lactating dairy cows. Journal of Dairy Science 72, 3240–3246.CrossRefGoogle ScholarPubMed
Girard, CL, Castonguay, F, Fahmy, MH & Matte, JJ (1996) Serum and milk folates during the first two gestations and laktations in Romanov, Finnsheep, and Suffolk ewes Journal of Animal Science 74, 1711–1715.CrossRefGoogle Scholar
Harper, AF, Lindemann, MD, Chiba, LI, Combs, GE, Handlin, DL, Kornegay, ET & Southern, LL (1994) An assessment of dietary folic acid levels during gestation and lactation on reproductive and lactational performance of sows A cooperative study. Journal of Animal Science 72, 2338–2344.CrossRefGoogle ScholarPubMed
Lynch, PB & Sheehy, PJA (1994) Response of breeding sows to long-term dietary supplementation with folic acid. Animal Production 58, 466.Google Scholar
Matte, JJ, Farmer, C, Girard, CL & Laforest, J-P (1996) Dietary folic acid, uterine function and early embryonic development in sows. Canadian Journal of Animal Science 76, 427–433.CrossRefGoogle Scholar
Matte, JJ & Girard, CL (1989) Effects of intramuscular injections of folic acid during lactation on folates in serum and milk and performance of sows and piglets. Journal of Animal Science 67, 426–431.CrossRefGoogle ScholarPubMed
Matte, JJ & Girard, CL (1999) An estimation of the requirement for folic acid in the gestating sow: The metabolism utilization of folates as a criterion of measurement. Journal of Animal Science 77, 159–165.CrossRefGoogle Scholar
Matte, JJ, Girard, CL & Brisson, GJ (1990) The effect of supplementary folic acid in gestation diets on folates status and reproductive performances of first parity sows. Journal of Animal Science 68, 370.Google Scholar
Matte, JJ, Girard, CL & Brisson, GJ (1984) Serum folates during the reproductive cycle of sows. Journal of Animal Science 59, 158–163.CrossRefGoogle ScholarPubMed
Matte, JJ, Girard, CL & Brisson, GJ (1992) The role of folic acid in the nutrition of gestating and lactating primiparous sows. Livestock Production Science 32, 131–148.CrossRefGoogle Scholar
Matte, JJ, Girard, CL & Tremblay, GF (1993) Effect of long-term addition of folic acid on folate status, growth performance, puberty attainment, and reproductive capacity of sows. Journal of Animal Science 71, 151–157.CrossRefGoogle Scholar
National Research Council (1998) Nutrient requirements of swine. 10th, Washington, DC: National Academy Press.Google Scholar
Natsuhori, M, Shimoda, M & Kokue, E (1996) Alterations of plasma folates in gestating sows and newborn piglets. American Journal of Physiology 270, R99-R104.Google ScholarPubMed
O'Connor, DL & Picciano, MF (1993) Plasma folate binding capacity of the reproducing pig. Journal of Nutritional Biochemistry 4, 482–487.CrossRefGoogle Scholar
O'Connor, DL, Picciano, MF, Roos, MA & Easter, RA (1989) Iron and folate utilization in reproducing swine and their progeny. Journal of Nutrition 119, 1984–1991.CrossRefGoogle ScholarPubMed
O'Connor, DL, Tamura, T & Picciano, MF (1991) Pteroylpolyglutamates in human milk. American Journal of Clinical Nutrition 53, 930–934.CrossRefGoogle ScholarPubMed
Rothenberg, SP, da Costa, M, Lawson, J & Rosenberg, Z (1974) The determination of erythrocyte folate concentration using a two-phase ligand-binding radioassay. Blood 43, 437–443.CrossRefGoogle ScholarPubMed
Selhub, J, Arnold, R, Smith, AM & Picciano, MF (1984) Milk folate protein (FBP) A secretory protein for folate. Nutrition Research 4, 181–187.CrossRefGoogle Scholar
German Society of Nutrition Physiology (1987) Energy and nutrient requirements of domestic animals. Vol. 4, Pigs 4. Frankfurt (Main): DLG-Verlag.Google Scholar
Tamura, T, Yoshimura, Y & Arakawa, T (1980) Human milk folate and folate status in lactating mothers and their infants. American Journal of Clinical Nutrition 33, 193–197.CrossRefGoogle ScholarPubMed
Thaler, RC, Nelssen, JL, Goodband, RD & Alle, GL (1989) Effect of dietary folic acid supplementation on sow performance through two parities. Journal of Animal Science 67, 3360–3369.CrossRefGoogle ScholarPubMed
Thenen, SW (1991) Gestational, and neonatal folate deficieny in rats Nutrition Research 11, 105–116.CrossRefGoogle Scholar
Tremblay, GF, Matte, JJ, Girard, CL & Brisson, GJ (1989) Serum zinc, iron and copper status during early gestation in sows fed a folic acid-supplemented diet. Journal of Animal Science 67, 733–737.CrossRefGoogle ScholarPubMed
Tremblay, GF, Matte, JJ, Lemieux, L & Brisson, GJ (1986) Serum folates in gestating swine after folic acid addition to diet. Journal of Animal Science 63, 1173–1178.CrossRefGoogle ScholarPubMed