Hostname: page-component-586b7cd67f-t8hqh Total loading time: 0 Render date: 2024-11-20T18:21:21.823Z Has data issue: false hasContentIssue false

Glutamine depletion impairs cellular stress response in human leucocytes

Published online by Cambridge University Press:  09 March 2007

Rudolf Oehler*
Affiliation:
Surgical Research Laboratories, University of Vienna, A-1090 Vienna, Austria
Erich Pusch
Affiliation:
Surgical Research Laboratories, University of Vienna, A-1090 Vienna, Austria
Peter Dungel
Affiliation:
Surgical Research Laboratories, University of Vienna, A-1090 Vienna, Austria
Maria Zellner
Affiliation:
Surgical Research Laboratories, University of Vienna, A-1090 Vienna, Austria
Maja Munk Eliasen
Affiliation:
Surgical Research Laboratories, University of Vienna, A-1090 Vienna, Austria
Marianne Brabec
Affiliation:
Surgical Research Laboratories, University of Vienna, A-1090 Vienna, Austria
Erich Roth
Affiliation:
Surgical Research Laboratories, University of Vienna, A-1090 Vienna, Austria
*
*Corresponding author: Dr Rudolf Oehler, Surgical Research Laboratories, AKH (8G9.05), Waehringer Guertel 18-20, A-1090 Vienna, Austria, fax +43 1 40400 6782, email [email protected]
Rights & Permissions [Opens in a new window]

Abstract

Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Research Article
Copyright
Copyright © The Nutrition Society 2002

References

Bachelet, M, Mariéthoz, E, Banzet, N, Souil, E, Pinot, F, Polla, C, Durand, P, Bouchaert, I & Polla, B (1998) Flow cytometry is a rapid and reliable method for evaluating heat shock protein 70 expression in human monocytes. Cell Stress & Chaperones 3, 168176.2.3.CO;2>CrossRefGoogle ScholarPubMed
Cai, JW, Hughes, CS, Shen, JW & Subjeck, JR (1991) Induction of heat-shock proteins by glutamine. The ‘feeding effect’. FEBS-Letters 288, 229232.CrossRefGoogle ScholarPubMed
Coligan, JE, Kruisbeek, AM, Margulies, DH, Shevach, EM & Strober, W (1996) Current protocols in immunology. In Current Protocols, [Cioco, R] New York, NY: John Wiley and Sons Inc.Google Scholar
Dressel, R & Gunther, E (1999) Heat-induced expression of MHC-linked HSP70 genes in lymphocytes varies at the single-cell level. Journal of Cellular Biochemistry 72, 558569.3.0.CO;2-X>CrossRefGoogle ScholarPubMed
Ehrenfried, JA, Chen, J, Li, J & Evers, BM (1995) Glutamine-mediated regulation of heat shock protein expression in intestinal cells. Surgery 118, 352356; discussion 356–357.CrossRefGoogle ScholarPubMed
Fincato, G, Polentarutti, N, Sica, A, Mantovani, A & Colotta, F (1991) Expression of a heat-inducible gene of the HSP70 family in human myelomonocytic cells: regulation by bacterial products and cytokines. Blood 77, 579586.CrossRefGoogle ScholarPubMed
Musch, MW, Hayden, D, Sugi, K, Straus, D & Chang, EB (1998) Cell-specific induction of HSP72-mediated protection by glutamine against oxidant injury in IEC18 cells. Proceedings of the Association of American Physicians 110, 136139.Google ScholarPubMed
Neu, J, Shenoy, V & Chakrabarti, R (1996) Glutamine nutrition and metabolism: where do we go from here?. FASEB Journal 10, 829837.CrossRefGoogle Scholar
Nissim, I, States, B, Hardy, M, Pleasure, J & Nissim, I (1993) Effect of glutamine on heat-shock-induced mRNA and stress proteins. Journal of Cellular Physiology 157, 313318.CrossRefGoogle ScholarPubMed
Petronini, PG, Urbani, S, Alfieri, R, Borghetti, AF & Guidotti, GG (1996) Cell susceptibility to apoptosis by glutamine deprivation and rescue: survival and apoptotic death in cultured lymphoma-leukemia cell lines. Journal of Cellular Physiology 169, 175185.3.0.CO;2-C>CrossRefGoogle ScholarPubMed
Polla, BS & Cossarizza, A (1996) Stress proteins in inflammation. In Stress-Inducible Cellular Responses, pp. 375–391 [Feige, U, Morimoto, R, Yahara, I and Polla, B, editors]. Basel: Birkhäuser Verlag.Google Scholar
Ribeiro, SP, Villar, J, Downey, GP, Edelson, JD & Slutsky, AS (1994) Sodium arsenite induces heat shock protein-72 kilodalton expression in the lungs and protects rats against sepsis [see comments]. Critical Care Medicine 22, 922929.CrossRefGoogle ScholarPubMed
Spittler, A, Oehler, R, Goetzinger, P, Holzer, S, Reissner, CM, Leutmezer, F, Rath, V, Wrba, F, Fuegger, R, Boltz Nitulescu, G & Roth, E (1997) Low glutamine concentrations induce phenotypical and functional differentiation of U937 myelomonocytic cells. Journal of Nutrition 127, 21512157.CrossRefGoogle ScholarPubMed
Spittler, A, Winkler, S, Götzinger, P, Oehler, R, Willheim, M, Tempfer, C, Weigel, G, Függer, R, Boltz Nitulescu, G & Roth, E (1995) Influence of glutamine on the phenotype and function of human monocytes. Blood 86, 15641569.CrossRefGoogle ScholarPubMed
Suzuki, K, Sawa, Y, Kaneda, Y, Ichikawa, H, Shirakura, R & Matsuda, H (1997) In vivo gene transfection with heat shock protein 70 enhances myocardial tolerance to ishemic-reperfusion injury in rat. Journal of Clinical Investigation 99, 16451650.CrossRefGoogle Scholar
Szondy, Z & Newsholme, EA (1991) The effect of time and addition of glutamine or nucleosides on proliferation of rat cervical lymphnode T-lymphocytes after stimulation with concavalin A. Biochemical Journal 278, 471474.CrossRefGoogle ScholarPubMed
Villar, J, Edelson, JD, Post, M, Mullen, JB & Slutsky, AS (1993) Induction of heat stress proteins is associated with decreased mortality in an animal model of acute lung injury. American Review of Respiratory Diseases 147, 177181.CrossRefGoogle Scholar
Villar, J, Ribeiro, SP, Mullen, JB, Kuliszewski, M, Post, M & Slutsky, AS (1994) Induction of the heat shock response reduces mortality rate and organ damage in a sepsis-induced acute lung injury model [see comments]. Critical Care Medicine 6, 914921.Google Scholar
Weingartmann, G, Oehler, R, Derkits, S, Oismuller, C, Fugger, R & Roth, E (1999) HSP70 expression in granulocytes and lymphocytes of patients with polytrauma: comparison with plasma glutamine. Clinical Nutrition 18, 121124.CrossRefGoogle ScholarPubMed
Welch, WJ (1991) The role of heat-shock proteins as molecular chaperones. Current Opinion in Cell Biology 6, 10331038.CrossRefGoogle Scholar
Wischmeyer, PE, Musch, MW, Madonna, MB, Thisted, R & Chang, EB (1997) Glutamine protects intestinal epithelial cells: role of inducible HSP70. American Journal of Physiology 272, G879884.Google ScholarPubMed