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Experimental zinc deficiency in guinea-pigs: biochemical changes

Published online by Cambridge University Press:  09 March 2007

R. P. Gupta ,
P. C. Verma  and
R. K. Paul Gupta
R. P. Gupta
Affiliation:
Department of Veterinary Pathology, Haryana Agricultural University, Hissar-125 004, India
P. C. Verma
Affiliation:
Department of Veterinary Pathology, Haryana Agricultural University, Hissar-125 004, India
R. K. Paul Gupta
Affiliation:
Department of Veterinary Pathology, Haryana Agricultural University, Hissar-125 004, India
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Abstract

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1. Zinc deficiency was produced experimentally in guinea-pigs fed on a diet containing 1.25 mg Zn/kg diet over a period of 60 d. In addition, the response of the Zn-deficient (ZnD) animals to Zn supplementation was studied for 15 d.

2. In the ZnD group a significant reduction was found in serum Zn and protein concentrations and in alkaline phosphatase (EC 3. 1. 3. 1; AP) activity from day 24 onwards.

3. Paper electrophoretic studies on serum revealed a significant decrease in relative values, as well as absolute values, of albumin and γ-globulin and an increase in β-globulin.

4. Albumin:globulin increased on day 24 but decreased significantly from day 48 onwards.

5. The kidney and testis of the ZnD group showed a reduction in Zn and protein contents, and AP activity.

6. Zn supplementation of the previously ZnD group resulted in marked although incomplete improvement in the biochemical indices studied.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 55 , Issue 3 , May 1986 , pp. 613 - 620
Copyright
Copyright © The Nutrition Society 1986

References

REFERENCES

Adeniyi, F. A. & Heaton, P. W. (1980). British Journal of Nutrition 43, 561–569.CrossRefGoogle Scholar
Alberts, J. C., Lang, J. A., Reyes, P. S. & Briggs, G. M. (1977). Journal of Nutrition 107, 1517–1527.CrossRefGoogle Scholar
Coles, E. H. (1967). Veterinary Clinical Pathology. Philadelphia and London: W. B. Saunders Co.Google Scholar
Gupta, R. P. (1984). Clinico-pathological studies on zinc deficiency in guinea-pigs. MVSc Thesis, Haryana Agricultural University, Hissar, India.Google Scholar
Gupta, R. P., Verma, P. C. & Gupta, R. K. Paul (1985) British Journal of Nutrition 54, 421–428.CrossRefGoogle Scholar
Hsieh, H. S. & Navia, J. M. (1980). Journal of Nutrition 110, 1581–1588.CrossRefGoogle Scholar
Hsu, J. M., Anthony, W. L. & Buchanan, P. J. (1969). Journal of Nutrition 97, 279–285.CrossRefGoogle Scholar
Hsu, J. M., Anthony, W. L. & Buchanan, P. J. (1970). In Trace Element Metabolism in Animals, pp. 151–158 [Miles, C. F., editor]. Edinburgh: Livingstone.Google Scholar
Huisman, T. H. I. (1963). Advances in Clinical Chemistry 6, 246–249.Google Scholar
Kirchgessner, M. & Pallauf, J. (1972). Zeitschrift für Tierphysiologie, Tierenährung und Futtermittelkunde 29, 77–85.CrossRefGoogle Scholar
Lewis, L. A. (1950). Electrophoresis in Physiology. Springfield: J. Charles & C. Thomas.Google Scholar
Lowry, O. H., Rosebrough, N. J., Farr, A. K. & Randall, R. J. (1951). Journal of Biological Chemistry 193, 265–275.CrossRefGoogle Scholar
Luetscher, J. A. Jr (1947). Physiological Reviews 27, 621.CrossRefGoogle Scholar
Macapinlac, M. P., Pearson, W. N. & Darby, W. J. (1966). In Zinc Metabolism, pp. 142–166 [Prasad, A. S., editor]. Springfield: J. Charles and C. Thomas.Google Scholar
McBean, L. D., Smith, J. C. Jr & Halsted, J. A. (1972). Proceedings of the Society for Experimental Biology and Medicine 140, 1207–1209.CrossRefGoogle Scholar
Prasad, A. S. & Oberleas, D. (1971). Journal of Applied Physiology 31, 842–846.CrossRefGoogle Scholar
Prasad, A. S. & Oberleas, D. (1976). Trace Elements in Human Health and Disease vol. 1. New York: Academic Press.Google Scholar
Quarterman, J. (1972). In Trace Element Merabolism in Animals, pp. 742–748 [Hoekstra, W. G., editor]. Baltimore: University Park Press.Google Scholar
Quarterman, J. & Humphries, W. R. (1983). Journal of Comparative Pathology 93, 261–270.CrossRefGoogle Scholar
Roth, H. P. & Kirchgessner, M. (1974). Zeitschrift für Tierphysiologie, Tierernährung und Futtermittelkunde 32, 289–296.CrossRefGoogle Scholar
Sandstead, H. H., Jerhune, M., Brady, R. N., Gillespie, D. & Hollaway, W. L. (1971). Clinical Research 19, 83.Google Scholar
Simpson, R. T. & Vallee, B. L. (1968). Biochemistry 7, 4343–4350.CrossRefGoogle Scholar
Tao, S. & Hurley, L. S. (1971). Proceedings of the Society for Experimental Biology and Medicine 136, 165–167.CrossRefGoogle Scholar
Underwood, E. J. (1977). Trace Elements in Human and Animal Nutrition. New York: Academic Press.Google Scholar
Wootton, I. D. P. (1974). Microanalysis in Medical Biochemistry, pp. 156–158. London: J. A. Churchill Livingstone.Google Scholar