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Eicosanoid production, thrombogenic ratio, and serum and LDL peroxides in normo- and hypercholesterolaemic post-menopausal women consuming two oleic acid-rich diets with different content of minor components

Published online by Cambridge University Press:  09 March 2007

Pilar Oubiña ,
Francisco J. Sánchez-Muniz ,
Sofía Ródenas  and
Carmen Cuesta
Pilar Oubiña
Affiliation:
Departamento de Nutrición y Bromatología I (Nutrición), Facultad de Farmacia, Universidad Complutense, E-28040 Madrid, Spain
Francisco J. Sánchez-Muniz*
Affiliation:
Departamento de Nutrición y Bromatología I (Nutrición), Facultad de Farmacia, Universidad Complutense, E-28040 Madrid, Spain
Sofía Ródenas
Affiliation:
Sección Departamental de Química Analítica, Facultad de Farmacia, Universidad Complutense, E-28040 Madrid, Spain
Carmen Cuesta
Affiliation:
Instituto de Nutrición y Bromatología, CSIC-UCM, Facultad de Farmacia, Universidad Complutense, E-28040 Madrid, Spain
*
*Corresponding author: Professor Dr Francisco J. Sánchez-Muniz, fax +34 91 3941732 email: [email protected]
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Abstract

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The present paper compares the effects of two monounsaturated oils, extra virgin olive oil (EVOO) and high-oleic acid sunflower oil (HOSO), on serum and LDL peroxides, eicosanoid production and the thrombogenic ratio (thromboxane (TX) B2:6-keto-prostaglandin F1α) in fourteen non-obese post-menopausal women. The subjects, mean age 63 (SD 11) years, were assigned to two consecutive oleic acid-rich 28 d dietary periods. EVOO and HOSO represented 62 % of the total lipid intake and were used as the only culinary fat during the first and second dietary periods respectively. Serum peroxides, plasma α-tocopherol and TXB2 levels in stimulated platelet-rich plasma (PRP-TXB2) were significantly higher (P<0.01, P<0.001, and P<0.05 respectively) after the HOSO diet than after the EVOO diet. The relationship between the serum cholesterol level (<6.21 mmol/l or ≥6.21 mmol/l) and the type of dietary oil on eicosanoids, peroxides and α-tocopherol were evaluated by two-way ANOVA. Dietary oil significantly affected (P<0.05) the PRP-TXB2 level, whereas serum and LDL peroxides were significantly affected (P<0.001 and P<0.01 respectively) by the serum cholesterol level. The plasma α-tocopherol level was significantly affected by the serum cholesterol level and the type of dietary oil (both P<0.001). No significant relationships were found between serum cholesterol levels, serum peroxide or LDL peroxide levels, plasma α-tocopherol concentrations or α-tocopherol intakes with eicosanoid production or the thrombogenic ratio due to dietary changes. However, in spite of their higher α-tocopherol levels, hypercholesterolaemic subjects showed increased peroxidation in serum and LDL in comparison with normocholesterolaemic subjects on the HOSO diet in comparison with the EVOO diet. These findings suggest that differences in the type of minor compounds, as well as in the concentration of linoleic acid, in both these monounsaturated oils may play an important role in modulating eicosanoid production and lipoprotein peroxidation when they constitute a large proportion of the diet of post-menopausal women.

Keywords

Monounsaturated oilsEicosanoid productionLipoprotein peroxidationα-Tocopherol
Type
Research Article
Information
British Journal of Nutrition , Volume 85 , Issue 1 , January 2001 , pp. 41 - 47
Copyright
Copyright © The Nutrition Society 2001

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