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Effects of simmondsin on food intake, growth, and metabolic variables in lean (+/?) and obese (fa/fa) Zucker rats

Published online by Cambridge University Press:  09 March 2007

G. Flo ,
S. Vermaut ,
V. M. Darras ,
M. Van Boven ,
E. Decuypere ,
R. Kühn ,
P. Daenens  and
M. Cokelaere
G. Flo
Affiliation:
Interdisciplinary Research Center, Katholieke Universiteit Leuven, Afdeling Kortrijk, E. Sabbelaan 53, B8500 Kortrijk, Belgium
S. Vermaut
Affiliation:
Laboratory of Physiology and Immunology of Domestic Animals, Katholieke Universiteit Leuven, K. Mercier Iaan 92, B3001 Leuven, Belgium
V. M. Darras
Affiliation:
Laboratory of Comparative Endocrinology, Katholieke Universiteit Leuven, Naamse straat 61, B3000 Leuven, Belgium
M. Van Boven
Affiliation:
Laboratory of Toxicology, Katholieke Universiteit Leuven, E. Van Evenstraat 4, B3000 Leuven, Belgium
E. Decuypere
Affiliation:
Laboratory of Physiology and Immunology of Domestic Animals, Katholieke Universiteit Leuven, K. Mercier Iaan 92, B3001 Leuven, Belgium
R. Kühn
Affiliation:
Laboratory of Comparative Endocrinology, Katholieke Universiteit Leuven, Naamse straat 61, B3000 Leuven, Belgium
P. Daenens
Affiliation:
Laboratory of Toxicology, Katholieke Universiteit Leuven, E. Van Evenstraat 4, B3000 Leuven, Belgium
M. Cokelaere*
Affiliation:
Interdisciplinary Research Center, Katholieke Universiteit Leuven, Afdeling Kortrijk, E. Sabbelaan 53, B8500 Kortrijk, Belgium
*
*Corresponding author: Professor M. Cokelaere, fax +32 56 246997, email [email protected]
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Abstract

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Incorporation of 2·5 g/kg of the anorexigen, simmondsin, in the diet resulted in food intake reduction in both lean and obese Zucker rats; however, the obese rats were much more sensitive to the food intake-reducing activity of simmondsin. In both obese and lean simmondsin-treated Zucker rats, growth was slower than in control rats, but was the same as that in pair-fed animals. The 24 h heat production pattern showed a smaller diurnal variation and a lower mean in obese rats than in lean rats. Food intake reduction, as a result of either simmondsin treatment or pair feeding, caused a decrease in mean heat production. Simmondsin treatment, but not pair feeding, caused a decrease in the diurnal variation of heat production. Plasma total cholesterol levels were increased in both simmondsin-treated and pair-fed obese and lean Zucker rats compared with control animals; this increase was mainly due to an increase in HDL-cholesterol levels. Blood leptin levels in both obese and lean rats decreased with decreased food intake and decreased fat deposition, but in obese rats, simmondsin treatment resulted in an additional decrease in leptin levels. It is concluded that the food intake-reducing effect of simmondsin is more pronounced in obese Zucker rats than in their lean littermates, and except for the simmondsin-specific effects on leptin and total cholesterol values in obese littermates, the effects of simmondsin are related to food intake restriction in obese and lean Zucker rats.

Keywords

SimmondsinFood intakeHeat production
Type
Research Article
Information
British Journal of Nutrition , Volume 81 , Issue 2 , February 1999 , pp. 159 - 167
Copyright
Copyright © The Nutrition Society 1999

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