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The effects of pregnancy and lactation on the activities of trypsin and α-chymotrypsin in the rat pancreas

Published online by Cambridge University Press:  09 March 2007

B. A. Rolls ,
M. J. Henschel  and
Maureen F. Palmer
B. A. Rolls
Affiliation:
National Institute for Research in Dairying, Shinfield, Reading RG2 9AT
M. J. Henschel
Affiliation:
National Institute for Research in Dairying, Shinfield, Reading RG2 9AT
Maureen F. Palmer
Affiliation:
National Institute for Research in Dairying, Shinfield, Reading RG2 9AT
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Abstract

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1. The food intake, pancreas weight and trypsin (EC 3.4.21.4) and α-chymotrypsin (EC 3.4.21.1) activities in the pancreas were measured in rats during pregnancy and lactation and after the young were weaned.

2. All the quantities measured increased significantly during lactation and had returned to their original values by 4 weeks after weaning. Food intake and pancreas weight were highest after the second week of lactation. Total trypsin and α-chymotrypsin activity, and the activity per g tissue, fell during pregnancy and rose during lactation, reaching a maximum I week after weaning.

3. From these and other results it is suggested that the hypertrophy and hypersecretion of pregnancy and lactation are initiated by changes in insulin secretion and mediated by the trophic effects of gut hormones, and that differences in the nature and timing of the response may be controlled by nutrient availability.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 41 , Issue 3 , May 1979 , pp. 573 - 578
Copyright
Copyright © The Nutrition Society 1979

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