Hostname: page-component-cd9895bd7-jkksz Total loading time: 0 Render date: 2024-12-23T16:19:34.595Z Has data issue: false hasContentIssue false
  • English
  • Français

Effects of dietary-fish-oil feeding on muscle growth and damage in the rat

Published online by Cambridge University Press:  09 March 2007

M. J. Jackson ,
J. Roberts  and
R. H. T. Edwards
M. J. Jackson
Affiliation:
Department of Medicine, University of Liverpool, PO Box 147, Liverpool L69 3BX
J. Roberts
Affiliation:
Department of Medicine, University of Liverpool, PO Box 147, Liverpool L69 3BX
R. H. T. Edwards
Affiliation:
Department of Medicine, University of Liverpool, PO Box 147, Liverpool L69 3BX
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. Giving diets containing 100 g fully-refined, non-hydrogenated fish oil/kg to rats caused substantial modification of skeletal-muscle-membrane fatty acid composition compared with control animals fed on an equivalent diet containing 100 g maize oil/kg.

2. Total muscle arachidonic acid (20:4ω6) was reduced from 138 (sd 25) mg/g total fatty acids to 15 (sd 2) mg/ g and phospholipid arachidonic acid content showed equivalent changes.

3. Reduction in muscle arachidonic acid content had no influence on the growth of individual muscles.

4. Variation in muscle fatty acid composition exacerbated the response of muscle to calcium-induced damage assessed by efflux of intracellular creatine kinase (EC 2.7.3.2).

5. It is concluded that metabolites of arachidonic acid are unlikely to be primary controlling factors of muscle growth or specific mediators of muscle sarcolemmal damage leading to enzyme efflux.

Type
Clinical and Human Nutrition papers: Studies Relevant to Human Nutrition
Information
British Journal of Nutrition , Volume 60 , Issue 2 , September 1988 , pp. 217 - 224
Copyright
Copyright © The Nutrition Society 1988

References

Claremont, D., Jackson, M. J. & Jones, D. A. (1984). Journal of Physiology 353, 57P.Google Scholar
Fischer, S., Schacky, C. V., Siess, W., Strasser, T. & Weber, P. C. (1982). Biochemical and Biophysical Research Communications 120, 907–918.CrossRefGoogle Scholar
Folch, J., Lees, M. & Sloane, G. H. (1957). Journal of Biological Chemistry 226, 497–509.CrossRefGoogle Scholar
Herold, P. M. & Kinsella, J. E. (1986). American Journal of Clinical Nutrition 43, 566–598.CrossRefGoogle Scholar
Hornstra, G. (1985). In Advances in Inflammation Research, Vol. 10, pp. 1–6 [Russo-Marie, F. editor]. New York: Raven Press.Google Scholar
Irvine, R. F. (1982). Biochemical Journal 204, 3–16.CrossRefGoogle Scholar
Jackson, M. J. & Edwards, R. H. T. (1988). In Reactive Oxygen Species in Chemistry, Biology and Medicine, pp. 197–210 [Quintanilla, A. editor]. New York: Plenum Press.CrossRefGoogle Scholar
Jackson, M. J., Jones, D. A. & Edwards, R. H. T. (1984). European Journal of Clinical Investigation 14, 369–374.CrossRefGoogle Scholar
Jackson, M. J., Wagenmakers, A. J. M. & Edwards, R. H. T. (1987), Biochemical Journal 241, 403–407.CrossRefGoogle Scholar
Jones, D. A., Jackson, M. J. & Edwards, R. H. T. (1983). Clinical Science 65, 193–201.CrossRefGoogle Scholar
Jones, D. A., Jackson, M. J., McPhail, G. & Edwards, R. H. T. (1984). Clinical Science 66, 317–322.CrossRefGoogle Scholar
Murphy, R. C., Pickett, W. C., Culp, B. R. & Lands, W. E. M. (1981). Prostaglandins 22, 613–622.CrossRefGoogle Scholar
Neudoerffer, T. S. & Lea, C. H. (1967). British Journal of Nutrition 21, 691–714.CrossRefGoogle Scholar
Norris, P. G., Jones, C. J. H. & Weston, M. J. (1986). British Medical Journal 293, 104–105.CrossRefGoogle Scholar
Palmer, R. M. & Wahle, K. W. (1987). Biochemical Journal 242, 615–618.CrossRefGoogle Scholar
Publicover, S. J., Duncan, C. J. & Smith, J. L. (1978). Journal of Neuropathology and Experimental Neurology 37, 544–577.CrossRefGoogle Scholar
Reeds, P. J. & Palmer, R. M. (1986). In Control and Manipulation of Animal Growth, pp. 161–185 [Buttery, F. P. J., Haynesand, N. B. and Lindsay, D.B, editors]. London: Butterworths.CrossRefGoogle Scholar
Rodemann, H. P., Waxman, L. & Goldberg, A. L. (1982). Journal of Biological Chemistry 257, 8716–8723.CrossRefGoogle Scholar
Smith, R. H., Palmer, R. M. & Reeds, P. J. (1983). Biochemical Journal 214, 153–161.CrossRefGoogle Scholar
Stubbs, C. D. & Smith, A. D. (1984). Biochimica et Biophysica Acta 779, 89–137.CrossRefGoogle Scholar
Woodcock, B. E., Smith, E., Lambert, W. H., Jones, W. M., Galloway, J. H., Greaves, M. & Preston, F. E. (1984). British Medical Journal 288, 592–594.CrossRefGoogle Scholar