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The effect of varying the sodium or potassium intake, or both, on magnesium status in the rat

Published online by Cambridge University Press:  09 March 2007

Judith A. Charlton  and
D. G. Armstrong
Judith A. Charlton
Affiliation:
Department of Agricultural Biochemistry and Nutrition, Faculty of Agriculture, University ofNewcastle upon Tyne, Newcastle upon Tyne NEI 7RU
D. G. Armstrong
Affiliation:
Department of Agricultural Biochemistry and Nutrition, Faculty of Agriculture, University ofNewcastle upon Tyne, Newcastle upon Tyne NEI 7RU
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Abstract

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Alterations in sodium or potassium intake, or both, affect the distribution and excretion of magnesium in man and animals. Experiments were performed on rats to investigate the effect of varying Na, K or Na+K intakes on Na, K and Mg excretion and plasma and tissue concentrations. In Expt 1, increasing the Na intake in a linear fashion produced a significant (P < 0.05) quadratic response in urinary Mg excretion, with a decrease followed by an increase as Na intake rose. No effect was observed on faecal excretion of Mg. Plasma and tissues were sampled at the end of an 18 d collection period; concentrations of aldosterone in plasma and Mg, Na and K in plasma and tissue were determined. Increasing Na intake in a linear fashion produced a significant (P < 0.05) quadratic effect on Mg concentration in heart and muscle, i.e. a decrease followed by an increase as Na intake rose; Na intake did not affect liver or bone Mg concentrations. There were no significant effects of Na intake on plasma Mg, Na or aldosterone but plasma K fell significantly (P < 0.01) as Na intake increased. In Expt 2, constant amounts of four diets supplying adequate or high levels of Na and adequate or high levels of K but a constant intake of Mg were given to rats. The rats fed on the adequate-Na diet had a significantly (P < 0.05) higher urinary Mg excretion than those fed on the high-Na diet; Na intake did not affect faecal Mg excretion.

Keywords

Magnesium statusPotassium intakeSodium intakeRat
Type
Lipids
Information
British Journal of Nutrition , Volume 62 , Issue 2 , September 1989 , pp. 399 - 406
Copyright
Copyright © The Nutrition Society 1989

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