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Effect of moderate magnesium deficiency on serum lipids, blood pressure and cardiovascular reactivity in normotensive rats

Published online by Cambridge University Press:  09 March 2007

Catherine Luthringer ,
Yves Rayssiguier ,
Elyett Gueux  and
Alain Berthelot
Catherine Luthringer
Affiliation:
Institut National de la Recherche Agronomique, Theix 63122 Ceyrat, France
Yves Rayssiguier
Affiliation:
Institut National de la Recherche Agronomique, Theix 63122 Ceyrat, France
Elyett Gueux
Affiliation:
Institut National de la Recherche Agronomique, Theix 63122 Ceyrat, France
Alain Berthelot
Affiliation:
Institut National de la Recherche Agronomique, Theix 63122 Ceyrat, France
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Abstract

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1. Weanling Wistar rats were pair fed for 10 weeks on a purified diet containing either normal or suboptimal quantities of magnesium (960 or 80 mg/kg respectively).

2. At week 2, hypomagnesaemia was accompanied by hypertriglyceridaemia, an increase in plasma cholesterol and a decrease in high-density-lipoprotein-cholesterol in animals fed on the Mg-deficient diet. At week 10, the increase in triglycerides observed in Mg-deficient animals was less marked while the increase in total cholesterol was more important.

3. During the whole experimental period, Mg-deficient animals never showed hypertension. At week 2, mean arterial blood pressure was significantly lower in Mg-deficient rats than in their respective controls, while heart rate was significantly increased. However, hypotension accompanied by tachycardia was a transitory phenomenon which appeared only in the early phase of deficiency.

4. Vascular reactivity was studied in vagotomized anaesthetized rats after ganglionic blockade with pentolinium and atropine sulphate. The reactivity to noradrenaline was significantly higher in Mg-deficient rats compared with pair-fed controls after 2 weeks on the experimental diet.

Type
Other Studies Relevant to Human Nutrition
Information
British Journal of Nutrition , Volume 59 , Issue 2 , March 1988 , pp. 243 - 250
Copyright
Copyright © The Nutrition Society 1988

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