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The effect of Maillard reaction products on zinc metabolism in the rat

Published online by Cambridge University Press:  09 March 2007

D. E. Furniss ,
J. Vuichoud ,
P. A. Finot  and
R. F. Hurrell
D. E. Furniss
Affiliation:
Nestec Ltd, Nestlé Research Centre, Vers-chez-les-Blanc, CH-1000 Lausanne 26, Switzerland
J. Vuichoud
Affiliation:
Nestec Ltd, Nestlé Research Centre, Vers-chez-les-Blanc, CH-1000 Lausanne 26, Switzerland
P. A. Finot
Affiliation:
Nestec Ltd, Nestlé Research Centre, Vers-chez-les-Blanc, CH-1000 Lausanne 26, Switzerland
R. F. Hurrell
Affiliation:
Nestec Ltd, Nestlé Research Centre, Vers-chez-les-Blanc, CH-1000 Lausanne 26, Switzerland
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Abstract

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The effect of giving Maillard reaction products (MRP) on zinc metabolism was investigated in the rat. In Expt 1, MRP were prepared by incubating casein with either glucose or lactose under controlled reaction conditions, and were quantified as either ‘early’ or ‘advanced’ after estimation of lysine loss and lysine destruction respectively. In Expt 2, the effect of the purified early MRP fructose–lysine (FL) on Zn metabolism was studied. The experimental diets containing 20 mg Zn/kg were given to weanling rats for 21 d. Zn balance was assessed over 9–14 d (Expt 1), or 1–14 d (Expt 2). Femur, liver, kidney and serum Zn concentrations were determined at 21 d. The major effect of the MRP in the casein-sugar mixtures was on urinary Zn excretion. The casein-glucose MRP induced up to a 6-fold increase in the quantity of Zn excreted in the urine. The magnitude of the hyperzincuria increased with the extent of the Maillard reaction. Similar dietary levels of casein-lactose MRP increased urinary Zn loss 2-fold. Free FL had no effect on urinary Zn. Faecal Zn, Zn retention, liver, femur and serum Zn were generally not influenced by giving MRP from casein-sugar mixtures or by giving free FL, although kidney Zn was decreased in rats fed on FL. It was concluded that although urinary Zn excretion can be increased by the presence of MRP in the diet, this is only a minor excretory pathway and would have little influence on overall Zn nutrition in individuals fed on a diet adequate in Zn.

Keywords

Maillard reaction productsZinc metabolismRat
Type
Minerals: Absorption and Metabolism
Information
British Journal of Nutrition , Volume 62 , Issue 3 , November 1989 , pp. 739 - 749
Copyright
Copyright © The Nutrition Society 1989

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