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The effect of environmental temperature on prandial changes in leucocyte sodium transport in man

Published online by Cambridge University Press:  09 March 2007

L. L. Ng  and
T. D. R. Hockaday
L. L. Ng
Affiliation:
Department of Clinical Pharmacology, Radcliffe Infirmary, Oxford OX2 6HE
T. D. R. Hockaday
Affiliation:
Sheikh Rashid Diabetes Unit, Radcliffe Infirmary, Oxford OX2 6HE
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Abstract

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Cellular sodium transport via the Na+, K+-ATPase contributes significantly to daily energy expenditure. The effect of a meal on leucocyte Na+ transport and intracellular electrolytes was therefore investigated in lean normal subjects at room temperatures of 23° and 33°, to determine if the Na pump responds to the need for thermogenesis. In the fasting state, the ouabain-sensitive efflux rate which reflects active Na+ transport, and the intracellular electrolytes were similar. At 2 h after eating a 4·2 MJ (1000 kcal) meal, the ouabain-sensitive efflux rate constant rose when the room temperature was 23° but not at 33°. The ouabain-sensitive Na+ efflux rate, an index of active Na+ transport, 0rose post-prandially at 23° only. The post-prandial activation of leucocyte active Na efflux in normal subjects was blunted at higher environmental temperatures, when the need for thermogenesis was reduced.

Keywords

ATPaseEnvironmental temperatureLeucocytesSodium transport
Type
Energy Metabolism
Information
British Journal of Nutrition , Volume 62 , Issue 3 , November 1989 , pp. 639 - 645
Copyright
Copyright © The Nutrition Society 1989

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