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Comparison of self-reported alcohol intake with the urinary excretion of 5-hydroxytryptophol:5-hydroxyindole-3-acetic acid, a biomarker of recent alcohol intake

Published online by Cambridge University Press:  09 March 2007

Anja Kroke ,
Kerstin Klipstein-Grobusch ,
Kurt Hoffmann ,
Ines Terbeck ,
Heiner Boeing  and
Anders Helander
Anja Kroke*
Affiliation:
Department of Epidemiology, German Institute of Human Nutrition, Bergholz-Rehbruecke, Germany
Kerstin Klipstein-Grobusch
Affiliation:
Department of Epidemiology, German Institute of Human Nutrition, Bergholz-Rehbruecke, Germany
Kurt Hoffmann
Affiliation:
Department of Epidemiology, German Institute of Human Nutrition, Bergholz-Rehbruecke, Germany
Ines Terbeck
Affiliation:
Department of Epidemiology, German Institute of Human Nutrition, Bergholz-Rehbruecke, Germany
Heiner Boeing
Affiliation:
Department of Epidemiology, German Institute of Human Nutrition, Bergholz-Rehbruecke, Germany
Anders Helander
Affiliation:
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
*
*Corresponding author: Dr Anja Kroke, fax +49 33200 88 304/444 email [email protected]
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Abstract

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Under-reporting of alcohol intake has been frequently reported. However, due to the lack of an objective reference method, e.g. a biomarker, information about the extent of under-reporting of alcohol intake obtained with dietary assessment instruments is not available. The objective of this study was to compare reported alcohol intake data derived from a 24 h recall with a biomarker of recent alcohol intake, the urinary excretion of 5-hydroxytryptophol (5-HTOL):5-hydroxyindole-3-acetic acid (5-HIAA). Embedded into the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study, Germany, a validation study that collected 24 h recall data and 24 h urine samples was conducted. Cohort study participants (n 107) volunteered to participate in this validation study. Among them were five subjects who reported no consumption of alcoholic beverages but had a 5-HTOL:5-HIAA ratio that indicated recent alcohol intake when the clinical cut-off point was taken as a judging criterion. After exclusion of these under-reporters, the Pearson's correlation coefficient between reported alcohol intake and the 5-HTOL:5-HIAA ratio was 0.92 (P<0.0001). Except for low alcohol intake of <0.1 g/kg body mass, a significant increase in 5-HTOL:5-HIAA excretion was observed with increasing amounts of alcohol intake. In conclusion, the 5-HTOL:5-HIAA excretion ratio appears to be a valuable quantitative biomarker of recent alcohol consumption. Denial of alcohol intake can be detected, but for the quantification of under-reporting of alcohol intake 24 h reference data are not yet available. With these data at hand, however, 5-HTOL:5-HIAA could become a biomarker for validation purposes in nutritional epidemiology.

Keywords

AlcoholBiomarkerEpidemiology
Type
Research Article
Information
British Journal of Nutrition , Volume 85 , Issue 5 , May 2001 , pp. 621 - 627
Copyright
Copyright © The Nutrition Society 2001

References

Anderson, P, Cremona, A, Paton, A, Turner, C & Wallace, P (1993) The risk of alcohol. Addiction 88, 1493–1508.Google Scholar
Beck, O, Helander, A, Carlsson, S & Borg, S (1995) Changes in serotonin metabolism during treatment with the aldehyde dehydrogenase inhibitors disulfiram and cyanamide. Pharmacology and Toxicology 77, 323–326.Google Scholar
Bingham, SA (1994) The use of 24-urine samples and energy expenditure to validate dietary assessments. American Journal of Clinical Nutrition 59(Suppl.), 227S–231S.CrossRefGoogle Scholar
Bingham, SA & Cummings, JH (1983) The use of 4-aminobenzoic acid as a marker to validate the completeness of 24-h urine collections in man. Clinical Science 64, 629–635.Google Scholar
Bingham, SA & Cummings, JH (1985) The use of creatinine output as a check on the completeness of 24-hour urine collections. Human Nutrition; Clinical Nutrition 39, 343–353.Google ScholarPubMed
Boeing, H, Korfmann, A & Bergmann, MM (1999) Recruitment procedures of EPIC-Germany. Annals of Nutrition and Metabolism 43, 205–215.CrossRefGoogle ScholarPubMed
Bofetta, P & Garfinkel, L (1990) Alcohol drinking and mortality among men enrolled in an American Cancer Society prospective study. Epidemiology 1, 342–348.Google Scholar
Damström Thakker, K (1998) An overview of health risks and benefits of alcohol consumption. Alcoholism: Clinical and Experimental Research 22(Suppl. 7), 285S–298S.Google Scholar
Davis, VE, Brown, H, Huff, JA & Cashaw, JL (1967) The alteration of serotonin metabolism to 5-hydroxytryptophol by ethanol ingestion in man. Journal of Laboratory and Clinical Medicine 69, 132–140.Google Scholar
Feunekes, GIJ, van't Veer, P, van Staveren, WA & Kok, FJ (1999) Alcohol intake assessment: The sober facts. American Journal of Epidemiology 150, 105–112.Google Scholar
Grobbee, DE, Rimm, EB, Keil, U, Renaud, S (1999) Alcohol and the cardiovascular system. In Health Issues Related to Alcohol Consumption. pp. 125–179.[MacDonald, I, editor]. Brussels: ILSI Europe.Google Scholar
Grønbaek, M & Heitmann, BL (1996) Validity of self-reported intakes of wine, beer and spirits in population studies. European Journal of Clinical Nutrition 50, 487–490.Google ScholarPubMed
Hagan, RL & Helander, A (1997) Vrinary 5-hydroxytryptophol following acute ethanol consumption: Clinical evaluation and potential aviation applications. Aviation Space and Environmental Medicine 68, 30–34.Google Scholar
Helander, A, Beck, O & Borg, S (1994 a) The use of 5-hydroxytryptophol as an alcohol intake marker. Alcohol and Alcoholism 2, 497–502.Google Scholar
Helander, A, Beck, O & Jones, AW (1996) Laboratory testing for recent alcohol consumption: comparison of ethanol, methanol, and 5-hydroxytryptophol. Clinical Chemistry 42, 618–624.Google Scholar
Helander, A, Beck, O, Wennberg, M, Wikström, T & Jacobsson, G (1991) Determination of urinary 5-hydroxyindole-3-acetic acid by high-performance liquid chromatography with electrochemical detection and direct sample injection. Analytical Biochemistry 196, 170–173.Google Scholar
Helander, A, Jones, AW (1998) Biochemical tests for acute and chronic alcohol ingestion Drug Abuse Handbook. 374–394.[Karch, S, editor]. Boca Raton, FL: CRC Press.Google Scholar
Helander, A, von Wachenfeldt, J, Hiltunen, A, Beck, O, Liljeberg, P & Borg, S (1999) Comparison of urinary 5-hydroxytryptophol, breath ethanol, and self-report for detection of recent alcohol use during outpatient treatment: a study on methadone patients. Drug and Alcohol Dependence 56, 33–38.Google Scholar
Helander, A, Walzer, C, Beck, O, Balant, L, Borg, S & von Wartburg, JP (1994) Genetic variation in alcohol dehydrogenase and aldehyde dehydrogenase and serotonin metabolism. Life Sciences 55, 359–366.CrossRefGoogle ScholarPubMed
Helander, A, Wikström, T, Löwenmo, C, Jacobsson, G & Beck, O (1992) Urinary excretion of 5-hydroxyindole-3-acetic acid and 5-hydroxytryptophol after oral loading with serotonin. Life Sciences 50, 1207–1213.CrossRefGoogle ScholarPubMed
Hiltunen, AJ, Koechling, UM, Voltaire-Carlsson, A & Borg, S (1996) Sub-populations of alcohol-dependent patients: differences in psychological functioning between high- and low-frequency alcohol consumers. Alcohol and Alcoholism 31, 429–438.CrossRefGoogle ScholarPubMed
Høyer, G, Nilssen, O, Brenn, T & Schirmer, H (1995) The Svalbard study 1988–89: a unique setting for validation of self-reported alcohol consumption. Addiction 90, 539–544.CrossRefGoogle ScholarPubMed
Jones, AW & Helander, A (1999) Time course and reproducibility of urinary excretion profiles of ethanol, methanol, and the ratio of serotonin metabolites after intravenous infusion of ethanol. Alcoholism – Clinical and Experimental Research 23, 1921–1926.Google Scholar
Klipstein-Grobusch, K, Georg, T & Boeing, H (1997) Interviewer variability in anthropometric measurements and estimates of body composition. International Journal of Epidemiology 26(Suppl. 1), S174–S180.Google Scholar
Kroke, A, Klipstein-Grobusch, K, Voss, S, Möseneder, J, Thielecke, F, Noack, R & Boeing, H (1999) Validation of a self-administered food frequency questionnaire administered in the EPIC-Potsdam Study: Comparison of reported energy, protein, and macronutrient intake with doubly labeled water, urinary nitrogen, and repeated 24-hour-recalls. American Journal of Clinical Nutrition 70, 439–447.Google Scholar
Longnecker, MP (1995) Alcohol consumption and risk of cancer in humans: an overview. Alcohol 12, 87–96.CrossRefGoogle ScholarPubMed
Midanik, LT (1988) Validity of self-reported alcohol use: a literature review and assessment. British Journal of Addiction 83, 1019–1030.CrossRefGoogle ScholarPubMed
Renaud, S, Criqui, MH, Farchi, G & Veenstra, J (1993) Alcohol drinking and coronary heart disease In Health Issues Related to Alcohol Consumption. 81–123. [Verschuren, PM, editor]. Washington, DC: ILSI Press.Google Scholar
Riboli, E (1992) Nutrition and cancer: background and rationale of the European Prospective Investigation into Cancer and Nutrition (EPIC). Annals of Oncology 3, 783–791.Google Scholar
Riboli, E & Kaaks, R (1997) The EPIC project: rationale and study design. International Journal of Epidemiology 26(Suppl. 1), S6–S14.CrossRefGoogle ScholarPubMed
Slimani, N, Deharveng, G, Charrondiere, RU, van Kappel, AL, Ocke, MC, Welch, A, Lagiou, A, van Liere, M, Agudo, A, Pala, V, Brandstetter, B, Andren, C, Stripp, C, van Staveren, WA & Riboli, E (1999) Structure of the standardized computerized 24-h diet recall interview used as reference method in the 22 centers participating in the EPIC project. European Prospective Investigation into Cancer and Nutrition. Computer Methods and Programs in Biomedicine 3, 251–266.CrossRefGoogle Scholar
Svensson, S, Some, M, Lundsjö, A, Helander, A, Cronholm, T & Höög, JO (1999) Activities of human alcohol dehydrogenase in the metabolic pathways of ethanol and serotonin. European Journal of Biochemistry 262, 324–329.Google Scholar
Voltaire, A, Beck, O & Borg, S (1992) Urinary 5-hydroxytryptophol: A possible marker of recent alcohol consumption. Alcoholism – Clinical and Experimental Research 16, 281–285.CrossRefGoogle ScholarPubMed
Voltaire #Carlsson, A, Hiltunen, AJ, Beck, O, Stibler, H & Borg, S (1993) Detection of relapses in alcohol-dependent patients: comparison of carbohydrate-deficient transferrin in serum, 5-hydroxytryptophol in urine, and self-reports. Alcoholism – Clinical and Experimental Research 17, 703–708.Google Scholar
Voss, S, Charrondiere, UR, Slimani, N, Kroke, A, Riboli, E, Wahrendorf, J & Boeing, H (1998) EPIC-Soft- ein europaweites Erfassungs- und Kodierungssystem fuer 24-Stunden-Erinnerungsprotokolle (EPIC-Soft - a European dietary assessment and coding tool for 24-hour recalls). Zeitschrift fuer Ernaehrungswissenschaft 37, 227–233.CrossRefGoogle Scholar
Walsh, MJ (1973) Role of acetaldehyde in the interactions of ethanol with neuroamines. Advances in Mental Sciences 3, 233–266.Google Scholar
Willett, W (1998) Nutritional Epidemiology. 2nd ed. New York, NY: Oxford University Press.Google Scholar