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Oswald Avery and the Origin of Molecular Biology

Published online by Cambridge University Press:  05 January 2009

Nicholas Russell
Nicholas Russell
Affiliation:
Department of Life Sciences, Bromley College of Technology, Rookery Lane, Bromley, Kent BR2 8HE, U.K.
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Extract

It is now twenty years since James Watson published his personal account of the discovery of the structure of DNA and triggered the growing scholarly study of the roots of molecular biology. Watson himself was not concerned with the study of nucleic acids before he became directly involved but at least three detailed histories of the early development of molecular biology have subsequently appeared, together with books, papers and reviews from others who took part, or their partisan representatives. Of these three histories, only one does justice to Avery's work. His surviving DNA collaborator, MacLyn McCarty, believes that only Olby in The Path to the Double Helix deals adequately with Avery's contribution.

Type
Research Article
Information
The British Journal for the History of Science , Volume 21 , Issue 4 , December 1988 , pp. 393 - 400
Copyright
Copyright © British Society for the History of Science 1988

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References

1 Watson, J.D., The Double Helix, London, 1968.Google Scholar

2 Olby, R., The Path to the Double Helix, London, 1974Google Scholar; Portugal, F.H. and Cohen, J.S., A Century of DNA, Cambridge, Mass., 1977Google Scholar; Judson, H.F., The Eighth Day of Creation, London, 1979.Google Scholar

3 McCarty, M., The Transforming Principle. Discovering that Genes are Made of DNA, New York, 1986, pp. 230–232.Google Scholar

4 Avery, O.T., McLeod, C.M. and McCarty, M., ‘Studies on the chemical nature of the substance inducing transformation of pneumococcal types. Induction of transformation by a desoxyribonucleic acid fraction isolated from Pneumococcus Type III’, Journal of Experimental Medicine (1944) 79, pp. 137–158.CrossRefGoogle ScholarPubMed

5 Watson, J.D. and Crick, F.H.C., ‘A structure for deoxyribose nucleic acid’, Nature (1953) 171, p. 737.CrossRefGoogle ScholarPubMed

6 Stent, G.S., ‘Prematurity and uniqueness in scientific discovery’, Scientific American (1972) 227, p. 84CrossRefGoogle ScholarPubMed; Wyatt, H.V., ‘When does information become knowledge’, Nature (1972) 235, pp. 86–89.CrossRefGoogle ScholarPubMed

7 Coburn, A.F., ‘Oswald Theodore Avery and DNA’, Perspectives in Biology and Medicine (1969) 12, pp. 623–30CrossRefGoogle ScholarPubMed; Diamond, A.M., ‘Avery's “neurotic reluctance”’, Perspectives in Biology and Medicine (1982) 26, pp. 132–136CrossRefGoogle ScholarPubMed; McCarty, , op. cit. 213–230Google Scholar; Olby, R., ‘Avery in retrospect’, Nature (1972) 239, p. 295.CrossRefGoogle Scholar

8 ‘I don't know who, in 1940, could possibly have foreseen that microbiology would furnish the links connecting biochemistry ever after with genetics’, Hotchkiss, R.D., ‘Gene, transforming principle and DNA’, In: Cairns, J., Stent, G. and Watson, J. D. (eds), Phage and the Origins of Molecular Biology, Cold Spring Harbour Laboratory of Quantitative Biology, 1966, p. 182.Google Scholar

9 Russell, N.C., ‘Breakthrough for the bloody-minded. A scientist's personality can be the key to his work’, Times Higher Education Supplement, 25 09 1987, p. 11.Google Scholar

10 Dubos, R.J., The Professor, the Institute and DNA, New York, 1976, pp. 47–48.Google Scholar

11 Dubos, , op. cit. (10), pp., 101–112, 161–179Google Scholar; Olby, , Double Helix, 181–193.Google Scholar

12 Griffith, F., ‘The significance of Pneumococcal types’, Journal of Hygiene (1928) 27, pp. 113–159.CrossRefGoogle ScholarPubMed

13 Dubos, , op. cit. (10), pp. 132–138Google Scholar; Hotchkiss, , 1966, op. cit. (8)Google Scholar; Stent, G.S. and Callendar, R., Molecular Genetics. An Introductory Narrative, San Francisco, 1978, pp. 152–159.Google Scholar

14 Dubos, , op. cit. (10), pp. 132–138Google Scholar; McCarty, , op. cit. (3), pp. 72–88Google Scholar; Olby, , Double Helix, 169–179.Google Scholar

15 Dubos, , op. cit. (10), pp. 132–138Google Scholar; McCarty, , op. cit. (3), pp. 72–88Google Scholar; Olby, , Double Helix, 173–179.Google Scholar

16 Olby, , Double Helix, 169–179.Google Scholar

17 Dubos, , op. cit. (10), pp. 80–85Google Scholar; Olby, , op. cit. (2), pp. 176–179Google Scholar; Goebel, W.F., ‘The golden era of immunology at the Rockefeller Institute’, Perspectives in Biology and Medicine, 18, pp. 417–426.Google Scholar

18 Dubos, , op. cit. (10), pp. 108–110, 116–119Google Scholar; Hotchkiss, R.D., ‘Oswald T. Avery 1877–1955’; Genetics (1965) 51, pp. 1–10.Google Scholar

19 Dubos, , op. cit. (10), pp. 80–85Google Scholar; MacLeod, C., ‘Oswald Theodore Avery 1877–1955’, Journal of General Microbiology (1957) 17, pp. 539–549CrossRefGoogle Scholar; Hotchkiss, , ‘Avery’.Google Scholar

20 Dubos, , op. cit. (10), pp. 113–123.Google Scholar

21 McCarty, , op. cit. (3), pp. 89–100.Google Scholar

22 McCarty, , op. cit. (3), pp. 86–88Google Scholar; Dubos, , op. cit. (10), pp. 65–68.Google Scholar

23 McLeod, , 1957, op. cit. (19), pp. 539–549.Google Scholar

24 Dubos, , op. cit. (10), pp. 97–99.Google Scholar

25 McCarty, , op. cit. (3), pp. 101–116.Google Scholar

26 McCarty, , op. cit. (3), pp. 134–135.Google Scholar

27 Hotchkiss, , 1966, op. cit. (8), pp. 183–184.Google Scholar

28 Hotchkiss, , 1965, (18), pp. 1–10.Google Scholar

29 Dubos, , op. cit. (10), pp. 69–85.Google Scholar

30 Dubos, , op. cit. (10), pp. 87–90.Google Scholar

31 MacLeod, , 1957, op. cit. (19), pp. 539–549Google Scholar; Dubos, , op. cit. (10), pp. 173–176.Google Scholar

32 Dubos, , op. cit. (10), pp. 35–68.Google Scholar

33 Dubos, , op. cit. (10), pp. 5–12.Google Scholar

34 Russell, N.C., ‘Towards a history of biology in the twentieth century. Directed autobiographies as historical sources’, British Journal for the History of Science (1988) 21, pp. 77–89.CrossRefGoogle ScholarPubMed