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Alterations in dorsal and ventral posterior cingulate connectivity in APOE ε4 carriers at risk of Alzheimer's disease

Published online by Cambridge University Press:  02 January 2018

Rebecca Kerestes ,
Pramit M. Phal ,
Chris Steward ,
Bradford A. Moffat ,
Simon Salinas ,
Kay L. Cox ,
Kathryn A. Ellis ,
Elizabeth V. Cyarto ,
David Ames  and
Ralph N. Martins
...Show all authors
Rebecca Kerestes*
Affiliation:
Department of Radiology, The Royal Melbourne Hospital, University of Melbourne, Parkville, Australia and Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Pramit M. Phal
Affiliation:
Department of Radiology, The Royal Melbourne Hospital, University of Melbourne, Parkville, Australia
Chris Steward
Affiliation:
Department of Radiology, The Royal Melbourne Hospital, University of Melbourne, Parkville, Australia
Bradford A. Moffat
Affiliation:
Department of Radiology, The Royal Melbourne Hospital, University of Melbourne, Parkville, Australia
Simon Salinas
Affiliation:
Department of Radiology, The Royal Melbourne Hospital, University of Melbourne, Parkville, Australia
Kay L. Cox
Affiliation:
School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
Kathryn A. Ellis
Affiliation:
Academic Unit for Psychiatry of Old Age, St. Vincent's Health, Department of Psychiatry, University of Melbourne, Melbourne, Australia
Elizabeth V. Cyarto
Affiliation:
National Ageing Research Institute, University of Melbourne, Parkville, Australia
David Ames
Affiliation:
Academic Unit for Psychiatry of Old Age, St Vincent's Health, Department of Psychiatry, University of Melbourne, Melbourne, Australia and National Ageing Research Institute, University of Melbourne, Parkville, Australia
Ralph N. Martins
Affiliation:
School of Medical Sciences, Edith Cowan University, Perth, Australia
Colin L. Masters
Affiliation:
The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia
Christopher C. Rowe
Affiliation:
Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Australia
Matthew J. Sharman
Affiliation:
School of Health Sciences, University of Tasmania, Hobart, Australia
Olivier Salvado
Affiliation:
Commonwealth Scientific Industrial Research Organization Preventative Health National Research Flagship, Australian e-Health Research Centre, Brisbane, Australia
Cassandra Szoeke
Affiliation:
National Ageing Research Institute, University of Melbourne, Parkville, Australia
Michelle Lai
Affiliation:
National Ageing Research Institute, University of Melbourne, Parkville, Australia
Nicola T. Lautenschlager
Affiliation:
Academic Unit for Psychiatry of Old Age, St. Vincent's Health, Department of Psychiatry, University of Melbourne, Melbourne, Australia and North Western Mental Health, Melbourne Health, Melbourne, Australia
Patricia M. Desmond
Affiliation:
Department of Radiology, The Royal Melbourne Hospital, University of Melbourne, Parkville, Australia
*
R. Kerestes, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Email: [email protected]
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Abstract

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Background

Recent evidence suggests that exercise plays a role in cognition and that the posterior cingulate cortex (PCC) can be divided into dorsal and ventral subregions based on distinct connectivity patterns.

Aims

To examine the effect of physical activity and division of the PCC on brain functional connectivity measures in subjective memory complainers (SMC) carrying the epsilon 4 allele of apolipoprotein E (APOE 4) allele.

Method

Participants were 22 SMC carrying the APOE ɛ4 allele (ɛ4+; mean age 72.18 years) and 58 SMC non-carriers (ɛ4–; mean age 72.79 years). Connectivity of four dorsal and ventral seeds was examined. Relationships between PCC connectivity and physical activity measures were explored.

Results

ɛ4+ individuals showed increased connectivity between the dorsal PCC and dorsolateral prefrontal cortex, and the ventral PCC and supplementary motor area (SMA). Greater levels of physical activity correlated with the magnitude of ventral PCC–SMA connectivity.

Conclusions

The results provide the first evidence that ɛ4+ individuals at increased risk of cognitive decline show distinct alterations in dorsal and ventral PCC functional connectivity.

Type
Research Article
Information
BJPsych Open , Volume 1 , Issue 2 , October 2015 , pp. 139 - 148
Creative Commons
Creative Common License - CCCreative Common License - BYCreative Common License - NCCreative Common License - ND
This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) licence (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Copyright
Copyright © The Royal College of Psychiatrists 2015

Footnotes

*

These authors contributed equally to this work.

Declaration of interest

D.A. has served on scientific advisory boards for Novartis, Eli Lilly, Janssen, Prana and Pfizer, and as Editor-in-Chief for International Psychogeriatrics; received speaker honoraria from Pfizer and Lundbeck, and research support from Eli Lilly, GlaxoSmithKline, Forest Laboratories, Novartis, and CSIRO. C.L.M. has received consulting fees from Eli Lilly and Prana Biotechnology, and has stock ownership in Prana Biotechnology. C.C.R. has received consultancy payments from Roche and Piramal, and research support from Avid Radiopharmaceuticals, Eli Lilly, GE Healthcare, Piramal and Navidea for amyloid imaging. C.S. has provided clinical consultancy and been on scientific advisory committees for the Australian CSIRO, Alzheimer's Australia, University of Melbourne and other relationships, which are subject to confidentiality clauses; she has been a named Chief Investigator on investigator-driven collaborative research projects in partnership with Pfizer, Merck, Piramal, Bayer and GE Healthcare. Her research programme has received support from the National Health and Medical Research Council Alzheimer's Association, Collier Trust, Scobie and Claire McKinnon Foundation, JO and JR Wicking Trust, Shepherd Foundation, Brain Foundation, Mason Foundation, Ramaciotti Foundation, Alzheimer's Australia and the Royal Australian College of Physicians.

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