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A common link between aging, schizophrenia, and autism?

Published online by Cambridge University Press:  14 February 2005

Jocelyn Faubert  and
Armando Bertone
Jocelyn Faubert*
Affiliation:
Visual Psychophysics and Perception Laboratory, École d'optométrie, Université de Montréal, MontréalH3C 1C1, Canadahttp://vision.opto.umontreal.ca
Armando Bertone*
Affiliation:
Visual Psychophysics and Perception Laboratory, École d'optométrie, Université de Montréal, MontréalH3C 1C1, Canadahttp://vision.opto.umontreal.ca
*
[email protected]
[email protected]
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Abstract:

Phillips & Silverstein (P&S, 2003) have proposed that NMDA-receptor hypofunction is the central reason for impaired cognitive coordination and abnormal gestalt-like perceptual processing in schizophrenia. We suggest that this model may also be applicable to non-pathological (or normal) aging given the compelling evidence of NMDA-receptor involvement during the aging process that results in age-related change in higher-level perceptual performance. Given that such deficits are present in other neurological disorders such as autism, an argument for a systematic assessment of perceptual functioning in these conditions may be posited.

Type
Continuing Commentary
Information
Behavioral and Brain Sciences , Volume 27 , Issue 4 , August 2004 , pp. 593 - 594
Copyright
Copyright © Cambridge University Press 2004

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Footnotes

Commentary onWilliam A. Phillips & Steven M. Silverstein (2003). Convergence of biological and psychological perspectives on cognitive coordination in schizophrenia. BBS 26(1):65–82.